64 research outputs found
Accreting Neutron Stars in Low-Mass X-Ray Binary Systems
Using the Rossi X-ray Timing Explorer (RossiXTE), astronomers have discovered
that disk-accreting neutron stars with weak magnetic fields produce three
distinct types of high-frequency X-ray oscillations. These oscillations are
powered by release of the binding energy of matter falling into the strong
gravitational field of the star or by the sudden nuclear burning of matter that
has accumulated in the outermost layers of the star. The frequencies of the
oscillations reflect the orbital frequencies of gas deep in the gravitational
field of the star and/or the spin frequency of the star. These oscillations can
therefore be used to explore fundamental physics, such as strong-field gravity
and the properties of matter under extreme conditions, and important
astrophysical questions, such as the formation and evolution of millisecond
pulsars. Observations using RossiXTE have shown that some two dozen neutron
stars in low-mass X-ray binary systems have the spin rates and magnetic fields
required to become millisecond radio-emitting pulsars when accretion ceases,
but that few have spin rates above about 600 Hz. The properties of these stars
show that the paucity of spin rates greater than 600 Hz is due in part to the
magnetic braking component of the accretion torque and to the limited amount of
angular momentum that can be accreted in such systems. Further study will show
whether braking by gravitational radiation is also a factor. Analysis of the
kilohertz oscillations has provided the first evidence for the existence of the
innermost stable circular orbit around dense relativistic stars that is
predicted by strong-field general relativity. It has also greatly narrowed the
possible descriptions of ultradense matter.Comment: 22 pages, 7 figures, updated list of sources and references, to
appear in "Short-period Binary Stars: Observation, Analyses, and Results",
eds. E.F. Milone, D.A. Leahy, and D. Hobill (Dordrecht: Springer,
http://www.springerlink.com
Factors driving patterns and trends in strandings of small cetaceans
The incidence of cetacean strandings is expected to depend on a combination of factors, including the dis- tribution and abundance of the cetaceans, their prey, and causes of mortality (e.g. natural, fishery bycatch), as well as currents and winds which affect whether carcasses reach the shore. We investigated spatiotemporal patterns and trends in the numbers of strandings of three species of small cetacean in Galicia (NW Spain) and their relationships with meteoro- logical, oceanographic, prey abundance and fishing-related variables, aiming to disentangle the relationship that may exist between these factors, cetacean abundance and mor- tality off the coast. Strandings of 1166 common dolphins (Delphinus delphis), 118 bottlenose dolphins (Tursiops truncatus) and 90 harbour porpoises (Phocoena phocoena) during 2000–2013 were analysed. Generalised additive and generalised additive-mixed model results showed that the variables which best explained the pattern of strandings of the three cetacean species were those related with local ocean meteorology (strength and direction of the North– South component of the winds and the number of days with South-West winds) and the winter North Atlantic Oscil- lation Index. There were no significant relationships with indices of fishing effort or landings. Only bottlenose dolphin showed possible fluctuations in local abundance over the study period. There was no evidence of long-term trends in number of strandings in any of the species and their abun- dances were, therefore, considered to have been relatively stable during the study period.Versión del editor2,01
Adjuvant interferon gamma in patients with drug – resistant pulmonary tuberculosis: a pilot study
BACKGROUND: Tuberculosis (TB) is increasing in the world and drug-resistant (DR) disease beckons new treatments. METHODS: To evaluate the action of interferon (IFN) gamma as immunoadjuvant to chemotherapy on pulmonary DR-TB patients, a pilot, open label clinical trial was carried out in the Cuban reference ward for the management of this disease. The eight subjects existing in the country at the moment received, as in-patients, 1 × 10(6 )IU of recombinant human IFN gamma intramuscularly, daily for one month and then three times per week up to 6 months as adjuvant to the indicated chemotherapy, according to their antibiograms and WHO guidelines. Sputum samples collection for direct smear observation and culture as well as routine clinical and thorax radiography assessments were done monthly. RESULTS: Sputum smears and cultures became negative for acid-fast-bacilli before three months of treatment in all patients. Lesion size was reduced at the end of 6 months treatment; the lesions disappeared in one case. Clinical improvement was also evident; body mass index increased in general. Interferon gamma was well tolerated. Few adverse events were registered, mostly mild; fever and arthralgias prevailed. CONCLUSIONS: These data suggest that IFN gamma is useful and well tolerated as adjunctive therapy in patients with DR-TB. Further controlled clinical trials are encouraged
Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and can be very efficiently treated with recanalization techniques, confirmation of this putative association is urgently warranted in a large representative patient cohort to alert stroke clinicians, and inform pre- and in-hospital acute stroke patient pathways. We pooled all consecutive patients hospitalized with laboratory-confirmed COVID-19 and acute ischemic stroke in 28 sites from 16 countries. To assess whether stroke severity and outcomes (assessed at discharge or at the latest assessment for those patients still hospitalized) in patients with acute ischemic stroke are different between patients with COVID-19 and non-COVID-19, we performed 1:1 propensity score matching analyses of our COVID-19 patients with non-COVID-19 patients registered in the Acute Stroke Registry and Analysis of Lausanne Registry between 2003 and 2019. Between January 27, 2020, and May 19, 2020, 174 patients (median age 71.2 years; 37.9% females) with COVID-19 and acute ischemic stroke were hospitalized (median of 12 patients per site). The median National Institutes of Health Stroke Scale was 10 (interquartile range [IQR], 4-18). In the 1:1 matched sample of 336 patients with COVID-19 and non-COVID-19, the median National Institutes of Health Stroke Scale was higher in patients with COVID-19 (10 [IQR, 4-18] versus 6 [IQR, 3-14]), P=0.03; (odds ratio, 1.69 [95% CI, 1.08-2.65] for higher National Institutes of Health Stroke Scale score). There were 48 (27.6%) deaths, of which 22 were attributed to COVID-19 and 26 to stroke. Among 96 survivors with available information about disability status, 49 (51%) had severe disability at discharge. In the propensity score-matched population (n=330), patients with COVID-19 had higher risk for severe disability (median mRS 4 [IQR, 2-6] versus 2 [IQR, 1-4], P<0.001) and death (odds ratio, 4.3 [95% CI, 2.22-8.30]) compared with patients without COVID-19. Our findings suggest that COVID-19 associated ischemic strokes are more severe with worse functional outcome and higher mortality than non-COVID-19 ischemic strokes
Dynamics of Disks and Warps
This chapter reviews theoretical work on the stellar dynamics of galaxy
disks. All the known collective global instabilities are identified, and their
mechanisms described in terms of local wave mechanics. A detailed discussion of
warps and other bending waves is also given. The structure of bars in galaxies,
and their effect on galaxy evolution, is now reasonably well understood, but
there is still no convincing explanation for their origin and frequency. Spiral
patterns have long presented a special challenge, and ideas and recent
developments are reviewed. Other topics include scattering of disk stars and
the survival of thin disks.Comment: Chapter accepted to appear in Planets, Stars and Stellar Systems, vol
5, ed G. Gilmore. 32 pages, 17 figures. Includes minor corrections made in
proofs. Uses emulateapj.st
Foot orthoses for the management of low back pain: a qualitative approach capturing the patient’s perspective
Background: The onset of non specific low back pain is associated with heavy lifting, age, female gender, and
poor general health, with psychological factors being predictors of it becoming chronic. Additionally, it is thought
that altered lower limb biomechanics are a contributory factor, with foot orthoses increasingly being considered as
an appropriate intervention by physiotherapists and podiatrists. However, research into the effect of foot orthoses is
inconclusive, primarily focusing on the biomechanical effect and not the symptomatic relief from the patient’s
perspective. The aim of this study was to explore the breadth of patients’ experiences of being provided with foot
orthoses and to evaluate any changes in their back pain following this experience.
Method: Following ethical approval, participants (n = 25) with non-specific low back pain associated with altered
lower limb biomechanics were provided with customised foot orthoses. At 16 weeks after being provided with the
foot orthoses, conversational style interviews were carried out with each patient. An interpretivistic
phenomenological approach was adopted for the data collection and analysis.
Results: For these participants, foot orthoses appeared to be effective. However, the main influence on this
outcome was the consultation process and a patient focussed approach. The consultation was an opportunity for
fostering mutual understanding, with verbal and visual explanation reassuring the patient and this influenced the
patient’s beliefs, their engagement with the foot orthoses (physical) and their experience of low back pain
(psychological).
Conclusion: Clinicians need to adopt ‘psychologically informed practice’ in relation to the provision of foot
orthoses. Likewise, researchers should consider all the influencing factors found in this study, both in relation to
their study protocol and the outcomes they plan to measure.
Keywords: Low back pain, Foot orthoses, Qualitative research, Informatio
Black hole spin: theory and observation
In the standard paradigm, astrophysical black holes can be described solely
by their mass and angular momentum - commonly referred to as `spin' - resulting
from the process of their birth and subsequent growth via accretion. Whilst the
mass has a standard Newtonian interpretation, the spin does not, with the
effect of non-zero spin leaving an indelible imprint on the space-time closest
to the black hole. As a consequence of relativistic frame-dragging, particle
orbits are affected both in terms of stability and precession, which impacts on
the emission characteristics of accreting black holes both stellar mass in
black hole binaries (BHBs) and supermassive in active galactic nuclei (AGN).
Over the last 30 years, techniques have been developed that take into account
these changes to estimate the spin which can then be used to understand the
birth and growth of black holes and potentially the powering of powerful jets.
In this chapter we provide a broad overview of both the theoretical effects of
spin, the means by which it can be estimated and the results of ongoing
campaigns.Comment: 55 pages, 5 figures. Published in: "Astrophysics of Black Holes -
From fundamental aspects to latest developments", Ed. Cosimo Bambi, Springer:
Astrophysics and Space Science Library. Additional corrections mad
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