Fossil CO2 and GHG emissions of all world countries

The Paris Agreement plans global stocktakes, to which the UNFCCC GHG emission inventories are the primary input. To complete this picture, the Emissions Database for Global Atmospheric Research provides for all world countries emission timeseries from 1970 until 2016 for CO2 and until 2012 for the other GHGs.JRC.C.5-Air and Climat

The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system

EDGAR v4.3.2 Global Atlas of the three major greenhouse gas emissions for the period 1970–2012

The Emissions Database for Global Atmospheric Research (EDGAR) compiles anthropogenic emissions data for greenhouse gases (GHGs), and for multiple air pollutants, based on international statistics and emission factors. EDGAR data provide quantitative support for atmospheric modelling and for mitigation scenario and impact assessment analyses as well as for policy evaluation. The new version (v4.3.2) of the EDGAR emission inventory provides global estimates, broken down to IPCC-relevant source-sector levels, from 1970 (the year of the European Union's first Air Quality Directive) to 2012 (the end year of the first commitment period of the Kyoto Protocol, KP). Strengths of EDGAR v4.3.2 include global geo-coverage (226 countries), continuity in time, and comprehensiveness in activities. Emissions of multiple chemical compounds, GHGs as well as air pollutants, from relevant sources (fossil fuel activities but also, for example, fermentation processes in agricultural activities) are compiled following a bottom-up (BU), transparent and IPCC-compliant methodology. This paper describes EDGAR v4.3.2 developments with respect to three major long-lived GHGs (CO2, CH4, and N2O) derived from a wide range of human activities apart from the land-use, land-use change and forestry (LULUCF) sector and apart from savannah burning; a companion paper quantifies and discusses emissions of air pollutants. Detailed information is included for each of the IPCC-relevant source sectors, leading to global totals for 2010 (in the middle of the first KP commitment period) (with a 95 % confidence interval in parentheses): 33.6(±5.9) Pg CO2 yr−1, 0.34(±0.16) Pg CH4 yr−1, and 7.2(±3.7) Tg N2O yr−1. We provide uncertainty factors in emissions data for the different GHGs and for three different groups of countries: OECD countries of 1990, countries with economies in transition in 1990, and the remaining countries in development (the UNFCCC non-Annex I parties). We document trends for the major emitting countries together with the European Union in more detail, demonstrating that effects of fuel markets and financial instability have had greater impacts on GHG trends than effects of income or population. These data (https://doi.org/10.5281/zenodo.2658138, Janssens-Maenhout et al., 2019) are visualised with annual and monthly global emissions grid maps of 0.1∘×0.1∘ for each source sector.JRC.C.5-Air and Climat

EDGAR v4.3.2 Global Atlas of the three major greenhouse gas emissions for the period 1970-2012

The Emissions Database for Global Atmospheric Research (EDGAR) compiles anthropogenic emissions data for greenhouse gases (GHGs), and for multiple air pollutants, based on international statistics and emission factors. EDGAR data provide quantitative support for atmospheric modelling and for mitigation scenario and impact assessment analyses as well as for policy evaluation. The new version (v4.3.2) of the EDGAR emission inventory provides global estimates, broken down to IPCC-relevant source-sector levels, from 1970 (the year of the European Union's first Air Quality Directive) to 2012 (the end year of the first commitment period of the Kyoto Protocol, KP). Strengths of EDGAR v4.3.2 include global geo-coverage (226 countries), continuity in time, and comprehensiveness in activities. Emissions of multiple chemical compounds, GHGs as well as air pollutants, from relevant sources (fossil fuel activities but also, for example, fermentation processes in agricultural activities) are compiled following a bottom-up (BU), transparent and IPCC-compliant methodology. This paper describes EDGAR v4.3.2 developments with respect to three major long-lived GHGs (HYDRO, CH4, and HYDRO) derived from a wide range of human activities apart from the land-use, land-use change and forestry (LULUCF) sector and apart from savannah burning; a companion paper quantifies and discusses emissions of air pollutants. Detailed information is included for each of the IPCC-relevant source sectors, leading to global totals for 2010 (in the middle of the first KP commitment period) (with a 95% confidence interval in parentheses): HYDRO PgCO HYDRO yr HYDRO, HYDRO PgCH HYDRO yr HYDRO, and HYDRO TgN HYDRO Oyr HYDRO. We provide uncertainty factors in emissions data for the different GHGs and for three different groups of countries: OECD countries of 1990, countries with economies in transition in 1990, and the remaining countries in development (the UNFCCC non-Annex I parties). We document trends for the major emitting countries together with the European Union in more for each source sector

High treatment uptake in human immunodeficiency virus/ hepatitis C virus-coinfected patients after unrestricted access to direct-acting antivirals in the Netherlands

Background The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide hepatitis C virus (HCV) treatment uptake among patients coinfected with human immunodeficiency virus (HIV) and HCV. Methods Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA result, did not have spontaneous clearance, and were known to still be in care. Treatment uptake and outcome were assessed. When patients were treated more than once, data were included from only the most recent treatment episode. Data were updated until February 2017. In addition, each treatment center was queried in April 2017 for a data update on DAA treatment and achieved sustained virological response. Results Of 23574 HIV-infected patients ever linked to care, 1471 HCV-coinfected patients (69% men who have sex with men, 15% persons who [formerly] injected drugs, and 15% with another HIV transmission route) fulfilled the inclusion criteria. Of these, 87% (1284 of 1471) had ever initiated HCV treatment between 2000 and 2017, 76% (1124 of 1471) had their HCV infection cured; DAA treatment results were pending in 6% (92 of 1471). Among men who have sex with men, 83% (844 of 1022) had their HCV infection cured, and DAA treatment results were pending in 6% (66 of 1022). Overall, 187 patients had never initiated treatment, DAAs had failed in 14, and a pegylated interferon-alfa–based regimen had failed in 54. Conclusions Fifteen months after unrestricted DAA availability the majority of HIV/HCV-coinfected patients in the Netherlands have their HCV infection cured (76%) or are awaiting DAA treatment results (6%). This rapid treatment scale-up may contribute to future HCV elimination among these patients