16,924 research outputs found

    On the "Poisson Trick" and its Extensions for Fitting Multinomial Regression Models

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    This article is concerned with the fitting of multinomial regression models using the so-called "Poisson Trick". The work is motivated by Chen & Kuo (2001) and Malchow-M{\o}ller & Svarer (2003) which have been criticized for being computationally inefficient and sometimes producing nonsense results. We first discuss the case of independent data and offer a parsimonious fitting strategy when all covariates are categorical. We then propose a new approach for modelling correlated responses based on an extension of the Gamma-Poisson model, where the likelihood can be expressed in closed-form. The parameters are estimated via an Expectation/Conditional Maximization (ECM) algorithm, which can be implemented using functions for fitting generalized linear models readily available in standard statistical software packages. Compared to existing methods, our approach avoids the need to approximate the intractable integrals and thus the inference is exact with respect to the approximating Gamma-Poisson model. The proposed method is illustrated via a reanalysis of the yogurt data discussed by Chen & Kuo (2001)

    Adipocyte mTORC1 Signaling Separately Regulates Metabolic Homeostasis and Adipose Tissue Mass, Independent of RagGTPase Activity

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    Metabolic disorders are commonly associated with obesity, a condition where excess caloric intake leads to massive adipose tissue (AT) expansion and eventual dysfunction. When adipose tissue loses its ability to store excess energy properly, lipids accumulate in non-adipose tissues such as liver, and muscle. This ectopic lipid deposition is a significant risk factor in the development of a collection of disorders described as metabolic syndrome. While metabolic syndrome is typically linked with obesity, patients who have an inability to develop adipose tissue depots (lipodystrophy) develop similar clinical outcomes. There is evidence that aberrant mTORC1 signaling may occur in both settings, and may be a factor that contributes to adipose dysfunction. I find that adipocyte specific loss of Raptor, a key mTORC1 subunit, leads to progressive lipoatrophy, and associated metabolic dysfunction including AT inflammation, hepatosteatosis, and insulin resistance. Interestingly, inhibition of autophagy, a pathway upregulated during Raptordeletion, prevents lipoatrophy but does not protect from ectopic lipid deposition and AT inflammation. These results suggest that outputs of mTORC1 in adipocytes individually regulate adipocyte storage capacity, and AT health. Furthermore, ablation of the amino acid sensing RagGTPases, thought to be necessary for mTORC1 activity, does not phenocopy Raptor KO, suggesting RagGTPase independent functions of mTORC1 in adipocytes. RagA/B deletion, however, did consistently increase Ucp1 expression in WAT, indicating a possible noncanonical role of the Rags in regulating Ucp1. Overall, these studies advance our understanding of regulation of adipose tissue metabolism, and shed light on previously unstudied nutrient specific signaling pathways in adipocytes

    Jet-like correlations between Forward- and Mid- rapidity in p+p, d+Au and Au+Au collisions from STAR at 200 GeV

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    In this proceedings we present STAR measurements of two particle azimuthal correlations between trigger particles at mid-rapidity (∣η∣<|\eta|< 1) and associated particles at forward rapidities (2.7 <∣η∣<<|\eta|< 3.9) in p+p, d+Au and Au+Au collisions at sNN\sqrt{s_{NN}} = 200 GeV. Two particle azimuthal correlations between a mid-rapidity trigger particle and forward-rapidity associated particles preferably probe large-x quarks scattered off small-x gluons in RHIC collisions. Comparison of the separate d- and Au-side measurements in d+Au collisions may potentially probe gluon saturation and the presence of Color Glass Condensate. In Au+Au collisions quark energy loss can be probed at large rapidities, which may be different from gluon energy loss measured at mid-rapidity.Comment: Quark Matter 06 Conference proceedings, submitted to Journal of Phys.

    Physics with Identified Particles at STAR

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    New physics results with identified particles at STAR are presented. Measurements at low pTp_T address bulk properties of the collision, while those at high pTp_T address jet energy loss in the bulk matter produced. Between these extremes, measurements at intermediate pTp_T address the interplay between jets and the bulk. We highlight: measurements of v2v_2 fluctuations as a new, sensitive probe of the initial conditions and the equation of state; correlations involving multi-strange particles, along with ratios of identified particles to test coalescence as a mechanism of particle production at intermediate pTp_T; three particle azimuthal correlation to search for conical emission; and the energy and particle-type dependence of hadron production at high pTp_T to study quark and gluon jet energy loss.Comment: 9 pages, 7 figures. To appear in the proceedings of the 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions (Quark Matter 2006), Shanghai, China, November 14-20, 200

    π,K,p\pi, K, p and pˉ\bar{p} production from Au+Au collisions at sNN=62.4\sqrt{s_{_{NN}}} = 62.4 GeV

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    The preliminary results of π±,K±,p\pi^{\pm}, K^{\pm}, p and pˉ\bar{p} spectra are reported from Au+Au collisions at sNN=62.4\sqrt{s_{_{NN}}} = 62.4 GeV. Particle identification is from the Time Projection Chamber and Time-of-Flight system at STAR. The nuclear modification factor RCPR_{CP} for mesons (π±,K±\pi^{\pm}, K^{\pm}) and baryons (p,pˉp, \bar{p}) will also be discussed.Comment: 5 pages, 4 figures, Contributed to 8th International Conference on Strangeness in Quark Matter (SQM 2004),to be published in Journal of Physics
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