Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus.

Transpl Int. 2007 Mar;20(3):291-6. Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus. Pedroso SL, Martins LS, Sousa S, Reis A, Dias L, Henriques AC, Sarmento AM, Cabrita A. Nephrology Department, Hospital Geral de Santo António, Porto, Portugal. [email protected] Abstract The aim of our paper is to describe an unusual pulmonary toxicity of sirolimus (SRL) in a kidney transplant recipient. We present a 34-year-old woman with a second renal transplantation, complicated with steroid-resistant acute rejection and chronic allograft dysfunction. Two years after initiating SRL, she presented complaints of progressive dyspnoea, nonproductive cough, chest pain and low-grade fever of 1 month duration. She had chronic allograft nephropathy and slight elevation of lactic dehydrogenase levels. After exclusion of common reasons of this condition, a computed tomography (CT) of the thorax and bronchoscopy was performed, revealing ground-glass opacification with polygonal shapes on CT and an opaque appearance with numerous macrophages on bronchoalveolar lavage. The alveolar macrophages stained positive by Periodic acid-Schiff. Diagnosis of pulmonary alveolar proteinosis (PAP) was made and drug-induced toxicity was suspected. SRL was withdrawn with marked improvement in the patients' clinical and radiological status. PAP resolved within 3 months without further therapy. PAP is a very rare complication of SRL therapy with only a few cases described. Withdrawal of SRL with conversion to another immunosuppressant seems to be an appropriate procedure in this condition. PMID: 17291222 [PubMed - indexed for MEDLIN

Encepamento do Dão: Adequação casta x porta-enxerto

São analisados os resultados de 30 anos de observações nos campos experimentais do Centro de Estudos Vitivinícolas do Dão, na adequação de quatro porta-enxertos a quatro castas tradicionais da região. Os resultados apontam, para uma nítida inferioridade no comportamento para todas as castas, do porta-enxerto Aramon nº1 ao nível do rendimento, sem ganhos de qualidade. Para os restantes porta-enxertos, o comportamento é variável com a casta, nos parâmetros observados. É de salientar a influência positiva do 110R no teor alcoólico das castas em estudo e a negativa do 420A. As castas Verdelho e Jaen apresentam os maiores teores de açúcar e a Jaen a acidez total mais baixainfo:eu-repo/semantics/publishedVersio

Carnívoros

Carnivoros (Carnivora)Esta obra foi financiada pela Fundação para a Ciência e a Tecnologia (FCT) e pelo FEDER/COMPETE 2020, através do projeto exploratório CP1168/CT0001 associado ao contrato IF/00266/2013 (programa Investigador FCT), tendo também beneficiado dos fundos POCI-01-0145-FEDER-006821 à unidade de investigação UID/BIA/50027 (Rede de Investigação em Biodiversidade e Biologia Evolutiva)