42 research outputs found
Improving the effectiveness of sickness benefit case management through a public-private partnership? A difference-in-difference analysis in eighteen Danish municipalities
- Author
- A Oakley
- AC Cameron
- AE Young
- AE Young
- B Aust
- Birgit Aust
- BK Graversen
- BT Gardner
- C Caroll
- CDG Stoltenberg
- E MacEachen
- E Yelin
- Eurostat
- F Schaafsma
- H Hlobil
- J Høgelund
- J Høgelund
- Jan Høgelund
- JD Angrist
- K Johansen
- K Johansen
- K Nielsen
- KT Palmer
- Malene Rode Larsen
- MB Nielsen
- MF Andersen
- MHT Martin
- MHT Martin
- MHT Martin
- OECD
- OM Poulsen
- P Craig
- P Loisel
- P Loisel
- PE Greenberg
- R Bille
- R-L Franche
- RL Franche
- S Schandelmaier
- T Lund
- The Danish Health and Medicines Authority Danish Centre for Health Technology Assessment
- V Borg
- W Shaw
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells
- Author
- Afshin Samali
- AM Clark
- AM Gonzales
- C Brede
- Chris Linehan
- Danforth E Jr
- E Hu
- E Wei
- G Ranganathan
- H Masuno
- H Masuno
- Hironori Waki
- IA Lang
- J Auwerx
- J Janke
- JA Brotons
- K Maeda
- L Aust
- LE Olofsson
- Lynn O'Connor
- M Merkel
- MA Lazar
- MD Lane
- MF Fernandez
- MJ Griffin
- N Olea
- PE Scherer
- PH Weinstock
- RH Unger
- RR Newbold
- S Gupta
- S Gupta
- Sanjeev Gupta
- SC Hung
- SD De Ferranti
- T Kidani
- W Song
- Y Nakano
- Y Zhang
- Publication venue
- Public Library of Science
- Publication date
- 25/05/2012
- Field of study
The endocrine disrupting chemical, bisphenol A (BPA), has been shown to accelerate the rate of adipogenesis and increase the amount of triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. The objective of this study was to investigate if that observation is mirrored in human primary cells. Here we investigated the effect of BPA on adipogenesis in cultured human primary adult stem cells. Continuous exposure to BPA throughout the 14 days of differentiation dramatically reduced triglyceride accumulation and suppressed gene transcription of the lipogenic enzyme, lipoprotein lipase (LPL). Results presented in the present study show for the first time that BPA can reduce triglyceride accumulation during adipogenesis by attenuating the expression of LPL gene transcription. Also, by employing image cytometric analysis rather than conventional Oil red O staining techniques we show that BPA regulates triglyceride accumulation in a manner which does not appear to effect adipogenesis per se
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
- AH Berg
- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
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- AI Bush
- AI Faden
- AJ Ghio
- AJ Ghio
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- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
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- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
- AR Kallianpur
- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
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- B De Vries
- B Desoize
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- B Faller
- B Goodell
- B Halliwell
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- B Wang
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- WB Ershler
- WB Kannel
- WI Leong
- WJ Jo
- WK Adkins
- WL Neeley
- WM Campana
- WR Farwell
- WR Markesbery
- WR Markesbery
- WS Jeong
- WS Yang
- WW Huber
- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease
- Author
- A Salgado-Somoza
- A Solini
- Aias Antoniadis
- B Staels
- B Vergès
- BM Kaess
- D Friebe
- E Ingelsson
- E Ingelsson
- Efstathios K Iliodromitis
- Eirini Maratou
- Erifili Hatziagelaki
- Fotios Kolokathis
- G Aust
- G Huang
- GA Christou
- George Dimitriadis
- H Hemingway
- HJ Kim
- J1 Cubedo
- John Parissis
- JW Lee
- K Takebayashi
- K1 Alwaili
- K1 Takebayashi
- KM Farjo
- LA1 Calò
- M Broch
- M Promintzer
- M von Eynatten
- MA Hlatky
- N Klöting
- Nikolaos PE Kadoglou
- NM Al-Daghri
- NP Kadoglou
- NP Kadoglou
- Q Sun
- Q Yang
- R Conroy
- S Martinez-Hervas
- SK1 Frey
- T Bobbert
- TC van Holten
- TE Graham
- Vaia Lambadiari
- Vassilios Stasinos
- Y Xiao
- Z Mallat
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Wettbewerbsvorsprung mit Conjoint Measurement
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2001
- Field of study
Absence of lipid peroxidation as determined by ethane exhalation in rats treated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Local Trapping Centers for Excitons in Molecular Crystals
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1980
- Field of study
Understanding and predicting epidemics: a commentary based on selected pathosystems
- Author
- Aust HJ
- Beresford RM
- Butt DJ
- Coakley SM
- Cohen L
- Eyal Z
- Jeger MJ
- Jenkyn JF
- Jones AL
- King JE
- Kirby EJ
- Kranz J
- Kremheller HT
- Lovell DJ
- Madden LR
- Morris RAC
- Neve RA
- Pei MH
- Preece TF
- Rotem J
- Rouse DI
- Royle DJ
- Royle DJ
- Royle DJ
- Royle DJ
- Royle DJ
- Royle DJ
- Royle DJ
- Royle DJ
- Seem RC
- Shaw MW
- Shaw MW
- Shaw MW
- Shaw MW
- Shaw MW
- Shaw MW
- Waggoner PE
- Waggoner PE
- Xu SM
- Zadoks JC
- Publication venue
- 'Wiley'
- Publication date
- 01/01/1994
- Field of study
Levels of malondialdehyde production in rat liver following loading and unloading with iron
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cementation and interface analysis of early failure cases after hip-resurfacing arthroplasty
- Author
- A Burkandt
- A Reito
- A Shimmin
- C Heisel
- H Pandit
- HC Amstutz
- HG Willert
- HS Gill
- J Zustin
- J Zustin
- J Zustin
- J Zustin
- JC Aust
- JJ Jacobs
- Jozef Zustin
- JP Little
- KH Andersen
- M Chandler
- M Hahn
- Matthias Krause
- Michael Amling
- Michael Hahn
- Michael M. Morlock
- MJ Askew
- MM Morlock
- MM Morlock
- P Campbell
- P Campbell
- P Morberg
- PE Beaule
- PE Beaule
- PH Hsieh
- RA Eriksson
- RG Bitsch
- RG Bitsch
- RG Bitsch
- Stefan Breer
- Wolfgang Rüther
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study