A comprehensive study on crosstalk suppression techniques in fiber optical parametric amplifier by modulation format

With the presence of multiple-WDM input signals, ON-OFF keying (OOK)-modulated signals suffer from crosstalk in fiber optical parametric amplifier (OPA) due to cross-gain modulation (XGM) and four-wave mixing (FWM) effects. We demonstrated substantial crosstalk suppression in one-pump OPA by using return-zero differential phase-shift keying (RZ-DPSK) modulation format, which with its pattern-independent amplitude and subunity duty cycle would be effective in reducing the XGM and FWM effects significantly. By using the RZ-DPSK format, the power penalty was improved by at least 0.8 dB over RZ-OOK, non-RZ (NRZ)-DPSK, and NRZ-OOK formats with four 10 Gb/s channels, separated by 200 GHz spacing. With eight 10 Gb/s channels separated by 100 GHz spacing, a Q -factor penalty of the RZ-DPSK signal was reduced by 2.4 dB compared to RZ-OOK counterparts. © 2008 IEEE.published_or_final_versio

All-optical tunable delay with NRZ-to-RZ format conversion capability based on optical Kerr switch and pulse pre-chirping

All-optical tunable delay plays an important role for enabling high-throughput optical routing, such as buffer for contention resolution and timing synchronization. We proposed and demonstrated a widely tunable optical delay using optical Kerr-switch-based wavelength converter and pulse pre-chirping for compensating chromatic dispersion in fiber delay. With wideband operation provided by a Kerr-switch wavelength converter, a tunable delay range up to 8.56 ns was achieved. Meanwhile, pulse pre-chirping helped to alleviate group-velocity dispersion (GVD)-induced penalty, and provided simultaneous nonreturn-zero (NRZ)-to-RZ format conversion functionality. © 2008 IEEE.published_or_final_versio

Comparison on crosstalk tolerance of RZ-DPSK and RZ-OOK modulation format in fiber optical parametric amplifier

We investigated crosstalk tolerance of RZ-DPSK and RZ-OOK modulation format in OPA with 100GHz channel spacing. Results show an average of 2.4dB improvement in Q factor by using RZ-DPSK format over RZOOK format.published_or_final_versio

Exercise-Induced Changes in Exhaled NO Differentiates Asthma With or Without Fixed Airway Obstruction From COPD With Dynamic Hyperinflation.

Asthmatic patients with fixed airway obstruction (FAO) and patients with chronic obstructive pulmonary disease (COPD) share similarities in terms of irreversible pulmonary function impairment. Exhaled nitric oxide (eNO) has been documented as a marker of airway inflammation in asthma, but not in COPD. To examine whether the basal eNO level and the change after exercise may differentiate asthmatics with FAO from COPD, 27 normal subjects, 60 stable asthmatics, and 62 stable COPD patients were studied. Asthmatics with FAO (n = 29) were defined as showing a postbronchodilator FEV(1)/forced vital capacity (FVC) ≤70% and FEV(1) less than 80% predicted after inhaled salbutamol (400 μg). COPD with dynamic hyperinflation (n = 31) was defined as a decrease in inspiratory capacity (ΔIC%) after a 6 minute walk test (6MWT). Basal levels of eNO were significantly higher in asthmatics and COPD patients compared to normal subjects. The changes in eNO after 6MWT were negatively correlated with the percent change in IC (r = −0.380, n = 29, P = 0.042) in asthmatics with FAO. Their levels of basal eNO correlated with the maximum mid-expiratory flow (MMEF % predicted) before and after 6MWT. In COPD patients with air-trapping, the percent change of eNO was positively correlated to ΔIC% (rs = 0.404, n = 31, P = 0.024). We conclude that asthma with FAO may represent residual inflammation in the airways, while dynamic hyperinflation in COPD may retain NO in the distal airspace. eNO changes after 6MWT may differentiate the subgroups of asthma or COPD patients and will help toward delivery of individualized therapy for airflow obstruction

Wide-band generation of picosecond pulse using fiber optical parametric amplifier and oscillator

We first demonstrate a wideband generation of picosecond pulse using fiber optical parametric amplifier (FOPA). High quality pulse is generated at 85 nm away from the pump with pulsewidth narrower than that of the pump. We then explore fiber optical parametric oscillator (FOPO) configuration which has the advantage of eliminating the need of seeding laser, leading to a potentially wider wavelength tunability and flexibility. The tuning range of the FOPO is from 1511 nm to 1541 nm and from 1583 nm to 1613 nm, which is as wide as 60 nm, with wavelength span of over 100 nm. Nearly-transform-limited sub-picosecond pulses are generated by this technique. © 2009 IEEE.published_or_final_versio

Regional differences in APD restitution can initiate wavebreak and re-entry in cardiac tissue: A computational study

Background Regional differences in action potential duration (APD) restitution in the heart favour arrhythmias, but the mechanism is not well understood. Methods We simulated a 150 × 150 mm 2D sheet of cardiac ventricular tissue using a simplified computational model. We investigated wavebreak and re-entry initiated by an S1S2S3 stimulus protocol in tissue sheets with two regions, each with different APD restitution. The two regions had a different APD at short diastolic interval (DI), but similar APD at long DI. Simulations were performed twice; once with both regions having steep (slope > 1), and once with both regions having flat (slope < 1) APD restitution. Results Wavebreak and re-entry were readily initiated using the S1S2S3 protocol in tissue sheets with two regions having different APD restitution properties. Initiation occurred irrespective of whether the APD restitution slopes were steep or flat. With steep APD restitution, the range of S2S3 intervals resulting in wavebreak increased from 1 ms with S1S2 of 250 ms, to 75 ms (S1S2 180 ms). With flat APD restitution, the range of S2S3 intervals resulting in wavebreak increased from 1 ms (S1S2 250 ms), to 21 ms (S1S2 340 ms) and then 11 ms (S1S2 400 ms). Conclusion Regional differences in APD restitution are an arrhythmogenic substrate that can be concealed at normal heart rates. A premature stimulus produces regional differences in repolarisation, and a further premature stimulus can then result in wavebreak and initiate re-entry. This mechanism for initiating re-entry is independent of the steepness of the APD restitution curve

Laparoscopic adjustable gastric band in an obese unrelated living donor prior to kidney transplantation: a case report

Introduction. Obese living donors who undergo donor nephrectomy have higher rates of intra-operative and post-operative complications. Many centres exclude obese donors from living donor transplant programs. Diet, exercise and medication are often ineffective weight loss interventions for donors, hence bariatric surgery should be considered. Case presentation. We report the case of a 53-year-old Caucasian woman who underwent laparoscopically adjustable gastric banding. The procedure enabled her to lose sufficient weight to gain eligibility for kidney donation. After losing weight, she had an uncomplicated laparoscopic donor nephrectomy surgery, and the recipient underwent successful kidney transplantation. Conclusion. Laparoscopically adjustable gastric banding should be considered for obese potential living kidney donors whenever transplantation units restrict access to donor nephrectomy based on the increased surgical risk for donors

Comparing factors affecting commencement and cessation of betel quid chewing behavior in Taiwanese adults

<p>Abstract</p> <p>Background</p> <p>Betel quid is the fourth most common used substance in the world after tobacco, alcohol and caffeine. Although factors related to betel quid chewing or cessation of behaviors were reported previously, few studies simultaneously compared both behaviors in the same population. In addition, it is essential to consider time-to-event concept, since the chance of developing or stopping habit may vary over time. The purpose of this study was to compare the risk factors for commencement and cessation of betel quid chewing behaviors in a time-to-event setting.</p> <p>Methods</p> <p>A stratified multi-stage cluster sampling with selection probabilities proportional to size (PPS) was designed for Taiwanese adults with aged 18 years old and above. Kaplan-Meier estimates and Cox proportional hazard regression models were used to compare and calculate the hazard rate ratios for related factors to commencement or cessation of chewing habits.</p> <p>Results</p> <p>In Taiwan, men had a higher betel quid chewing rate (M: 20.9%, W: 1.2%), but woman chewers had a lower cessation rate (M: 27.5%, W: 12.7%). The hazard rate ratio (HRR) of having chewing habit changed from 4.22 (men vs women) univariately to 1.38 multivariablely, which indicated gender differences were confounded by other factors. In multivariable analysis, the risk factors of gender, education and ethnicity were significantly associated with both starting and cessation of betel quid chewing behavior. The factors of occupation, cigarette smoking and alcohol drinking were only associated with starting habit.</p> <p>Conclusion</p> <p>Commencement or cessation of chewing behavior involves a scenario of time, hence it is preferable to use a time-to-event approach for the comparison. The cessation rates of betel quid chewing were decreasingly associated with the daily consumption of betel quid. Hence, reducing of daily amount in betel quid cessation program may be associated with future stopping habit.</p