Determinação da carga de treino nos exercícios supino e rosca bíceps em mulheres jovens Defining the training load in bench press and biceps curl exercises in young women

O objetivo deste estudo foi avaliar a força máxima dinâmica (1RM) nos exercícios supino e rosca scott, e relacioná-la com a massa corporal total (MCT) e com a massa corporal magra (MCM), bem como avaliar o número máximo de repetições em diferentes percentuais de 1RM. Onze mulheres (24 ± 1,4 anos) foram submetidas à avaliação da composição corporal, testes de 1RM e testes de repetições máximas em 50, 60, 70 e 80% de 1RM. No tratamento dos dados, foram utilizados a regressão linear múltipla, a ANOVA para medidas repetidas e o teste t pareado. A MCM é a variável que melhor explica a variância de 1RM, podendo ser utilizada para a determinação de um coeficiente para a estimativa da carga de treino. Houve diferenças significativas entre os números de repetições em todos os percentuais e em ambos os exercícios [(supino (p=0,000) e rosca scott (p=0,000)], sendo esses números progressivamente menores com o incremento da carga.<br>The purpose of this study was to assess maximum strength (1RM) in the bench press and biceps curl exercises, and relate it to total body mass (BM) and fat-free mass (FFM), as well as to assess the maximum repetition number at different percentages of 1-RM. Eleven women (age: 24 ± 1.4 years) were submitted to body composition assessment, 1-RM tests, and maximum repetition tests at 50, 60, 70 and 80% of 1-RM. For data treatment, multiple linear regression, repeated measures ANOVA and paired t-test were used. FFM explains better than BM the 1-RM variance and can be used to determine a coefficient to estimate the training load. Significant differences were found in the maximum repetition numbers in all percentages and both exercises (bench press (p=0,000) and biceps curl (p=0,000). These results revealed a gradual decrease in the number of repetitions as the load increased

A sensory appendage protein protects malaria vectors from pyrethroids

Pyrethroid-impregnated bednets have driven significant reductions in malaria morbidity and mortality in Africa since the beginning of the century 1. The intense selection pressure exerted by bednets has precipitated widespread and escalating pyrethroid resistance in African Anopheles populations, threatening to reverse gains made by malaria control 2. Here we show that a leg-enriched sensory appendage protein, SAP2, confers pyrethroid resistance in Anopheles gambiae. SAP2 expression is elevated in insecticide-resistant populations and is further induced upon mosquito contact with pyrethroids. SAP2 silencing fully restores mosquito mortality, whilst its overexpression results in increased resistance, likely due to the high-affinity SAP2 binding to pyrethroid insecticides. Mining of genome sequence data reveals a selective sweep near the SAP2 locus in three West African countries, with the observed increase in haplotype associated SNPs mirroring increasing resistance reported in Burkina Faso. Our study identifies a new insecticide resistance mechanism that is likely highly relevant to malaria control efforts