29 research outputs found
Zone mapping application for precision-farming: a decision support tool for variable rate application
Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies
Microneedles: A New Frontier in Nanomedicine Delivery
This review aims to concisely chart the development of two individual research fields, namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles (MP), and microneedle (MN) technologies, which have, in the recent past, been exploited in combinatorial approaches for the efficient delivery of a variety of medicinal agents across the skin. This is an emerging and exciting area of pharmaceutical sciences research within the remit of transdermal drug delivery and as such will undoubtedly continue to grow with the emergence of new formulation and fabrication methodologies for particles and MN. Firstly, the fundamental aspects of skin architecture and structure are outlined, with particular reference to their influence on NP and MP penetration. Following on from this, a variety of different particles are described, as are the diverse range of MN modalities currently under development. The review concludes by highlighting some of the novel delivery systems which have been described in the literature exploiting these two approaches and directs the reader towards emerging uses for nanomedicines in combination with MN
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Complex event detection in extremely resource-constrained wireless sensor networks
Complex Events are sequences of sensor measurements indicating interesting or unusual activity in the monitored process. Such events are ubiquitous in a wide range of Wireless Sensor Network (WSN) applications, yet there does not exist a common mechanism that addresses both the considerable constraints of WSNs and the specific properties of Complex Events. We argue that Complex Events cannot be described using standard threshold-based or composite logic approaches and attempting to represent them as such can lead to unpredictable execution cost while detection accuracy suffers from erroneous recording of observations which are common in WSNs. To address this, we develop a family of Complex Event Detection (CED) algorithms based on online symbolic conversion of sensor readings. With fixed execution cost and modest resource requirements, the CED algorithms cater for exact, approximate, non-parametric, multiple and probabilistic detection that is neither application nor data dependent. Overall, full implementation and simulations provide experimental evidence of the advantages of the proposed approach. We find that the proposed algorithms minimise configuration, promote unattended operation and complement the goal of prolonged lifetime-factors that satisfy the long-term research vision predicting Internet-scale WSNs comprising billions of devices