Figs and kippers

This article aims to connect three topics: Brexit, Boris and the decay of democracy. What connects this trio is talk, talk, talk. Language and politics are tightly and necessarily intertwined. Indeed, as the Greeks thought, language is intertwined with democracy itself. The twenty-first century has brought unprecedented complexity to human ways of communication, and yet the old rhetorical tricks and oratorical stunts, first described and practised in the ancient world, are still capable of turning heads. As we learn more about how human language works in social and political settings, we can see even more clearly a few of the factors that enable lying politicians to acquire power. But we are still far from drawing practical lessons that could be relevant to our current political crisis

Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

Background: Human osteosarcoma is the most common pediatric bone tumor. There is limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis, and a lack of good diagnostic as well as prognostic clinical markers for this disease. Recent discoveries have highlighted a potential role of a number of genes including: RECQL4, DOCK5, SPP1, RUNX2, RB1, CDKN1A, P53, IBSP, LSAMP, MYC, TNFRSF1B, BMP2, HISTH2BE, FOS, CCNB1, and CDC5L. Methods: Our objective was to assess relative expression levels of these 16 genes as potential biomarkers of osteosarcoma oncogenesis and chemotherapy response in human tumors. We performed quantitative expression analysis in a panel of 22 human osteosarcoma tumors with differential response to chemotherapy, and 5 normal human osteoblasts.Results: RECQL4, SPP1, RUNX2, and IBSP were significantly overexpressed, and DOCK5, CDKN1A, RB1, P53, and LSAMP showed significant loss of expression relative to normal osteoblasts. In addition to being overexpressed in osteosarcoma tumor samples relative to normal osteoblasts, RUNX2 was the only gene of the 16 to show significant overexpression in tumors that had a poor response to chemotherapy relative to good responders. Conclusion: These data underscore the loss of tumor suppressive pathways and activation of specific oncogenic mechanisms associated with osteosarcoma oncogenesis, while drawing attention to the role of RUNX2 expression as a potential biomarker of chemotherapy failure in osteosarcoma. © 2010 Sadikovic et al; licensee BioMed Central Ltd

Identification of Parelaphostrongylus odocoilei (Nematoda: Protostrongylidae) First-Stage Larvae in the Feces of Gray Wolves (Canis lupus) by Molecular Methods

First-stage nematode larvae with a dorsal-spine (DSL) were detected in five of 1,565 fecal samples from gray wolves (Canis lupus) collected in British Columbia, Canada, between 2005 and 2008. Molecular techniques were used to identify the DSL because it was not possible to determine their species identity using morphologic characters. The DSL were identified as Parelaphostrongylus odocoilei based on the results of single-strand conformation polymorphism (SSCP) analyses and DNA sequencing of the ribosomal DNA first and second internal transcribed spacers. Finding DSL of P. odocoilei in the feces of gray wolves was unexpected because P. odocoilei adults are parasites of cervids and bovids. The most likely explanation for the presence of DSL in wolf feces is that they were ingested along with the viscera of recently consumed prey. This was probably black-tailed deer (Odocoileus hemionus columbianus), which are known in the sampling area to be hosts of P. odocoilei. The present study demonstrates the use of SSCP and DNA sequencing for the identification, to the species level, of parasitic nematode larvae in feces

Frenzy: Collaborative data organization for creating conference sessions

Organizing conference sessions around themes improves the experience for attendees. However, the session creation process can be difficult and time-consuming due to the amount of expertise and effort required to consider alternative paper groupings. We present a collaborative web application called Frenzy to draw on the efforts and knowledge of an entire program committee. Frenzy comprises (a) interfaces to support large numbers of experts working collectively to create sessions, and (b) a two-stage process that decomposes the session-creation problem into meta-data elicitation and global constraint satisfaction. Meta-data elicitation involves a large group of experts working simultaneously, while global constraint satisfaction involves a smaller group that uses the meta-data to form sessions. We evaluated Frenzy with 48 people during a deployment at the CSCW 2014 program committee meeting. The session making process was much faster than the traditional process, taking 88 minutes instead of a full day. We found that meta-data elicitation was useful for session creation. Moreover, the sessions created by Frenzy were the basis of the CSCW 2014 schedule.Ford-MIT AllianceNational Science Foundation (U.S.) (Award SOCS-1111124)National Science Foundation (U.S.) (Award SOCS-1208382)United States. Office of Naval Research (Grant N00014-12-1-0211)National Science Foundation (U.S.) (Grant IIS 1016713)National Science Foundation (U.S.) (Grant IIS-1110965