STATISTICAL METHODS TO ESTIMATE NATURAL FREQUENCY OF AIR CONDITIONER PIPING

Resonance is a critical phenomena in the designing of any structure. Piping structure, which is one of the several elements of air conditioning and refrigeration system, undergo severe vibration. In practice different approaches such as experimental, analytical, numerical and statistical methods are used to study vibration characteristics of a structure. Statistical method acts as a first hand tool to judge the behaviour of a system. Statistical methods minimise redesign process and expensive methods of controlling vibrations, saving significant amount of effort, cost and time. In the present study, statistical methods are used to estimate fundamental natural frequency of a pipe by selecting different geometrical parameters. The natural frequency obtained can be used to check resonance. Geometrical parameters, which significantly affect the natural frequency, are estimated by using Design of Experiments (DOE) and Analysis of Variance (ANOVA) techniques. A linear equation that predicts fundamental frequency is formulated using regression analysis. Frequencies predicted by regression model are compared to frequencies obtained from ANSYS Mechanical©. A good correlation is found with error less than 5%

Performance up gradation of static VAR compensator with thyristor binary switched capacitor and reactor using model reference adaptive controller

There are various static var compensator configurations are available and listed in the literature. Their performances are evaluated based on their voltage support, dynamic response, losses, cost, and additional filter requirement, if any. In this paper, efforts are made to improve the dynamic performance parameter such as rise time, settling time, and peak overshoots. A new topology with an adaptive controller is presented, in which capacitor and reactor banks are divided in their binary values and connected in the shunt. Capacitor and reactor banks are operated by thyristorised switches. Both these banks are operated in closed-loop form as a cascade control. Amongst these, capacitor bank operates as coarse control, and reactor bank acts as fine control. For the performance enhancement, a model reference adaptive controller is used. The system identification toolbox is used to evaluate the mathematical model of the plant with Matlab. The model\u27s performance was analyzed deeply by the adaptive controller with different reference models such as critical, under, and overdamped. The performance parameters such as rise time, settling time, and peak overshoot in the form of reactive power swings, are evaluated and plotted for different adaptive gains using MIT rules

To study the efficacy of Mustadi Churna in Pandu Roga w.s.r. Haemoglobin percentage

Pandu is the disease which is described by all major classical texts of Ayurveda. As per Ayurvedic text in Pandu Roga the color of body look like polen grain of Ketki flower. Due to its similarity we can correlate Pandu Roga with modern science anaemia disease. Rasavaha and Raktavaha Strotasa are commonly involved in pathogenesis of Pandu Roga. Pandu if not treated properly can bring serious consequences to our health. Different Kalpas were described in Ayurved Samhitas for the treatment of Pandu Roga. In present study we use Mustadi Churna in the treatment of Pandu Roga and assess its efficacy

Ayurveda management of Osteo Arthritis (Sandhigata Vata) - A Case Study

Osteoarthritis is the most common form of arthritis affecting millions of people worldwide. It occurs when the protective cartilage that cushions the end of your bone wears down overtime. In Ayurveda osteoarthritis correlate to Sandhigat Vata. The common sign and symptoms of this disease is present in the form of Shoola, Shotha, Vatapoornadriti Sparsha and difficulty in flexion and extension of Sandhi. In modern science the available treatment is use of NSAID, Calcium supplement and finally replacement therapy. Due to this there are large no of patients suffering from this disease come towards Ayurveda. Ayurveda treatment by its Chikitsa Siddhant gives remarkable relief in osteoarthritis. In this case study a 60 yrs patient suffering from osteoarthritis of both knee joint got good relief

Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and Future Perspective

Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent. Self nanoemulsifying formulations (SNEF) are isotropic mixtures of lipids/oils, surfactants and co-surfactants. On mild agitation followed by dilution in aqueous media, such as GI fluids, SNEF can form fine oil-in-water (o/w) nanoemulsions. Present chapter summarizes different types of lipid formulations with special emphasis on SNEF, availability of dosage forms, different components with natural surfactants from medicinal plants, mechanism of SNEF, recent advancements in oral drug delivery, solid SNEDDS, patents on SNEF and future prospects. SNEF emerging as powerful technique to improve solubility and commercialization of solid SNEF is the future novel drug delivery to improve bioavailability of poorly water soluble drugs

Role of Drug Repurposing in Cancer Treatment and Liposomal Approach of Drug Targeting

Cancer is the leading cause of death, and incidences are increasing significantly and patients suffering from it desperately need a complete cure from it. The science of using an already-invented drug that has been approved by the FDA for a new application is known as “drug repurposing.” Currently, scientists are drawn to drug repositioning science in order to investigate existing drugs for newer therapeutic uses and cancer treatment. Because of their unique ability to target cancer cells, recently repurposed drugs and the liposomal approach are effective in the treatment of cancer. Liposomes are nanovesicles that are drastically flexible, rapidly penetrate deeper layers of cells, and enhance intracellular uptake. More importantly, liposomes are biocompatible, biodegradable; entrap both hydrophobic and hydrophilic drugs. This chapter summarizes various approaches to drug repurposing, as well as drug repurposing methods, advantages and limitations of drug repurposing, and a liposomal approach to using repurposed drugs in cancer targeting. This chapter also summarizes liposomal structure, drug loading, and the mechanism of liposomes in targeted cancer treatment. The lipid-based liposomal approach is emerging as a powerful technique for improving drug solubility, bioavailability, reducing side effects, and improving the therapeutic efficacy of repurposed drugs for cancer treatment

Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools