47 research outputs found
Thermodynamics of Dipolar Chain Systems
The thermodynamics of a quantum system of layers containing perpendicularly
oriented dipolar molecules is studied within an oscillator approximation for
both bosonic and fermionic species. The system is assumed to be built from
chains with one molecule in each layer. We consider the effects of the
intralayer repulsion and quantum statistical requirements in systems with more
than one chain. Specifically, we consider the case of two chains and solve the
problem analytically within the harmonic Hamiltonian approach which is accurate
for large dipole moments. The case of three chains is calculated numerically.
Our findings indicate that thermodynamic observables, such as the heat
capacity, can be used to probe the signatures of the intralayer interaction
between chains. This should be relevant for near future experiments on polar
molecules with strong dipole moments.Comment: 15 pages, 5 figures, final versio
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions
Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death from infection before COVID-19. Here, we developed a framework for multiple pharmaceutical companies to share proprietary information and compounds with multiple laboratories in the academic and government sectors for a broad examination of the ability of β-lactams to kill Mycobacterium tuberculosis (Mtb). In the TB Drug Accelerator (TBDA), a consortium organized by the Bill & Melinda Gates Foundation, individual pharmaceutical companies collaborate with academic screening laboratories. We developed a higher order consortium within the TBDA in which four pharmaceutical companies (GlaxoSmithKline, Sanofi, MSD, and Lilly) collectively collaborated with screeners at Weill Cornell Medicine, the Infectious Disease Research Institute (IDRI), and the National Institute of Allergy and Infectious Diseases (NIAID), pharmacologists at Rutgers University, and medicinal chemists at the University of North Carolina to screen ∼8900 β-lactams, predominantly cephalosporins, and characterize active compounds. In a striking contrast to historical expectation, 18% of β-lactams screened were active against Mtb, many without a β-lactamase inhibitor. One potent cephaloporin was active in Mtb-infected mice. The steps outlined here can serve as a blueprint for multiparty, intra- and intersector collaboration in the development of anti-infective agents