Revista iberoamericana de educación

Resumen basado en la publicaciónNúmero especial que acompaña al monográfico "Didáctica de la Lengua y la Literatura"Se evalúan los cambios de desempeño ocurridos a lo largo de un programa de intervención con alumnos del 5º año de escolaridad y orientado al desarrollo de la fluidez en lectura. Se llevaron a cabo 13 sesiones quincenales, guiadas por profesores de portugués, con una duración de 45 minutos. En el programa participaron todos los alumnos de la escuela donde se desarrolló el proyecto, pero a efectos de evaluación, fueron seleccionados aleatoriamente 54 alumnos. Se registraron diferencias estadísticamente significativas en la reducción en el tiempo de lectura y en el número de errores. Los resultados muestran que el programa tuvo efecto en todos los alumnos. A pesar de los cambios observados, aunque los alumnos con peores desempeños han mejorado, siguen teniendo resultados inferiores al de sus pares con mejores desempeños. Los resultados encontrados son similares a los reportados en estudios que evaluaron el efecto de programas de intervención dirigida para el desarrollo de la fluidez lectora, en años escolares anteriores al del presente estudio. Dado que los progresos en la recuperación son menores a medida que la escolaridad aumenta, los resultados obtenidos pueden considerarse relevantes.ES

The Pediatric Symptom Checklist as screening tool for neurological and psychosocial problems in a paediatric cohort of patients with coeliac disease.

AIM: To screen for neurological and behavioural disorders in a paediatric cohort of patients with coeliac disease (CD) in order to detect possible differences related to compliance with gluten-free diet (GFD). METHODS: We recruited a cohort of 139 patients divided into three groups: A (40 patients with newly diagnosed CD), B (54 patients with CD in remission after GFD) and C (45 patients with potential CD). Patients first underwent a screening neurological visit, detecting signs associated with CD, and then were evaluated with Pediatric Symptom Checklist (PSC), a psychosocial screen for cognitive, emotional and behavioural problems. RESULTS: In the group B as compared to group A, there was a statistically significant decrease (p < 0.05) in the incidence of chronic fatigue, headache and inattention. The same applied to patients compliant to GFD vs. non-compliant. Potential coeliacs turning into overt CD had a higher incidence of headache and inattention compared with potential coeliacs showing normal mucosa. The PSC mean score in group A was statistically higher than in group B. CONCLUSION: Gluten-free diet had a positive impact on neuropsychiatric symptoms. We suggest the use of PSC in the routine follow-up of coeliacs in order to allow an early detection of psychosocial problems

Epilessia da deficit di PNPO: follow-up di 5 anni.

Viene descritto il follow-up di una paziente con una rarissima forma di epilessia ad esordio neonatale

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System

Pancreatic Cancer (PC) is one of the most aggressive malignancies worldwide. As annexin A1 (ANXA1) is implicated in the establishment of tumour metastasis, the role of the protein in PC progression as a component of extracellular vesicles (EVs) has been investigated. EVs were isolated from wild type (WT) and ANXA1 knock-out (KO) PC cells and then characterised by multiple approaches including Western blotting, Field Emission-Scanning Electron Microscopy, and Dynamic Light Scattering. The effects of ANXA1 on tumour aggressiveness were investigated by Wound-Healing and invasion assays and microscopic analysis of the Epithelial to Mesenchymal Transition (EMT). The role of ANXA1 on angiogenesis was also examined in endothelial cells, using similar approaches. We found that WT cells released more EVs enriched in exosomes than those from cells lacking ANXA1. Notably, ANXA1 KO cells recovered their metastatic potential only when treated by WT EVs as they underwent EMT and a significant increase of motility. Similarly, human umbilical vein endothelial cells (HUVEC) migrated and invaded more rapidly when treated by WT EVs whereas ANXA1 KO EVs weakly induced angiogenesis. This study suggests that EVs-related ANXA1 is able to promote cell migration, invasion, and angiogenesis, confirming the relevance of this protein in PC progression

Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs

We have recently demonstrated that mesoglycan, a fibrinolytic compound, may be a promising pro-healing drug for skin wound repair. We showed that mesoglycan induces migration, invasion, early differentiation, and translocation to the membrane of keratinocytes, as well as the secretion of annexin A1 (ANXA1), further involved in keratinocytes activation. These events are triggered by the syndecan-4 (SDC4)/PKCα pathway. SDC4 also participates to the formation and secretion of microvesicles (EVs) which may contribute to wound healing. EVs were isolated from HaCaT cells, as human immortalized keratinocytes, and then characterised by Western blotting, Field Emission-Scanning Electron Microscopy, and Dynamic Light Scattering. Their autocrine effects were investigated by Wound-Healing/invasion assays and confocal microscopy to analyse cell motility and differentiation, respectively. Here, we found that the mesoglycan increased the release of EVs which amplify its same effects. ANXA1 contained in the microvesicles is able to promote keratinocytes motility and differentiation by acting on Formyl Peptide Receptors (FPRs). Thus, the extracellular form of ANXA1 may be considered as a link to intensify the effects of mesoglycan. In this study, for the first time, we have identified an interesting autocrine loop ANXA1/EVs/FPRs in human keratinocytes, induced by mesoglycan

Psicothema

Resumen tomado de la publicaciónValidez de un test de comprensión lectora para alumnos portugueses. Antecedentes: el objetivo de este trabajo fue recoger evidencia de validez de constructo y de criterio para un test de comprensión lectora (TCL- Teste de Compreensão da Leitura) con tres versiones escaladas verticalmente para evaluar alumnos portugueses de segundo, tercero y cuarto cursos de Primaria. Método: se efectuaron dos estudios. En el primero (n= 1,229) se analizó la dimensionalidad de la prueba recurriendo al análisis factorial confirmatorio. En el segundo (n= 402) se proporcionan datos sobre evidencia de validez concurrente y predictiva, analizando las correlaciones entre los resultados en TCL, los resultados en otras pruebas de lectura y los resultados académicos. Resultados: los análisis factoriales confirmatorios revelaron que el modelo de un factor se ajusta a los datos. Se obtuvieron coeficientes de correlación bajos a moderados y estadísticamente significativos entre las puntuaciones en el TCL y en otros tests de lectura. Las puntuaciones en TCL predijeron las puntuaciones obtenidas por los alumnos en los exámenes nacionales de lengua portuguesa y en las competencias de comprensión evaluadas por los maestros. Conclusiones: estos resultados proporcionan evidencia empírica para la validez de las versiones de TCL.Universidad de Oviedo. Biblioteca de Psicología; Plaza Feijoo, s/n.; 33003 Oviedo; Tel. +34985104146; Fax +34985104126; [email protected]

Access to Health Services and Assistance Offered to the Afro-Descendant Communities in Northern Brazil: A Qualitative Study

The remnants of quilombos, individuals of African descent, have faced several barriers throughout its history, either due to prejudice imposed by society, or the non-fulfillment of their rights guaranteed in the 1988 Constitution, such as access to health services. Thus, this study aims to evaluate the health care offered to quilombo communities in the northern region of Tocantins. This is an exploratory, descriptive study with a qualitative approach, including field research and focus group, carried out with 58 quilombo remnants people from communities in the northern region of Tocantins. Data collection was carried out between from October 2017 to July 2018, through semi-structured interviews. We found that these communities have limited access to health services, in addition to a negative perception of the assistance offered to the health of their population and the commitment of managers. Therefore, access to health and assistance received by the studied communities required to be prioritized since the care provided is not unique and has not met the health demands and needs of the remaining quilombos in northern Tocantins, Brazil