18 research outputs found
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Tourist Behavior of People with Autism Spectrum Disorder
Consumer behavior studies in the field of tourism aim to explain why tourists make certain decisions related to their travels. Researchers analyze demographic data such as age, gender, income, and family life cycle to account for the differences among people in consumer behavior studies. However, neurodiversity is often overlooked. Understanding the unique experiences of people with ASD requires a tailored tourist behavior model as there is a lack of a conceptual model that describes the travel experiences of tourists with ASD. This study aims to propose a research agenda on tourist behavior of people with ASD through identifying the knowledge gaps in the current literature on tourists with ASD and a thorough review of previous models of tourist behavior
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TIPS AND TRAPS: METHODOLOGICAL ISSUES RELATED TO CONDUCTING AN ONLINE TRIP PLANNING STUD
This study examines methodological issues related to studying American college students’ online travel planning behavior. A mixed method approach, which integrated think-aloud protocol combined with the process tracing method, log analysis and survey techniques, was evaluated in this paper. In previous studies, this methodological approach has been subject to issues of reliability and validity that were addressed in the design of the current study. Specifically, questions were related to whether the experiment used in this study would yield results comparable to the decision-making and search processes respondents would engage upon on their real-life trip planning. The purpose of this paper was to discuss how this study has evolved from previous work in this area in order to increase reliability and validity. Issues regarding the artificiality of the environment are addressed in this paper. Overall it was found that the qualitative- based, mixed-method approach used in this study was deemed appropriate and has resulted in delivering insights into the phenomena of online travel planning
CD3Z Genetic Polymorphism in Immune Response to Hepatitis B Vaccination in Two Independent Chinese Populations
Vaccination against hepatitis B virus is an effective and routine practice that can prevent infection. However, vaccine-induced immunity to hepatitis B varies among individuals. CD4+ T helper cells, which play an important role in both cellular and humoral immunity, are involved in the immune response elicited by vaccination. Polymorphisms in the genes involved in stimulating the activation and proliferation of CD4+ T helper cells may influence the immune response to hepatitis B vaccination. In the first stage of the present study, a total of 111 single nucleotide polymorphisms (SNPs) in 17 genes were analyzed, using the iPLEX MassARRAY system, among 214 high responders and 107 low responders to hepatitis B vaccination. Three SNPs (rs12133337 and rs10918706 in CD3Z, rs10912564 in OX40L) were associated significantly with the immune response to hepatitis B vaccination (P = 0.008, 0.041, and 0.019, respectively). The three SNPs were analyzed further with the TaqMan-MGB or TaqMan-BHQ probe-based real-time polymerase chain reaction in another independent population, which included 1090 high responders and 636 low responders. The minor allele ‘C’ of rs12133337 continued to show an association with a lower response to hepatitis B vaccination (P = 0.033, odds radio = 1.28, 95% confidence interval = 1.01–1.61). Furthermore, in the stratified analysis for both the first and second populations, the association of the minor allele ‘C’ of rs12133337 with a lower response to hepatitis B vaccination was more prominent after individuals who were overweight or obese (body mass index ≥25 kg/m2) were excluded (1st stage: P = 0.003, 2nd stage: P = 0.002, P-combined = 9.47e-5). These findings suggest that the rs12133337 polymorphism in the CD3Z gene might affect the immune response to hepatitis B vaccination, and that a lower BMI might increase the contribution of the polymorphism to immunity to hepatitis B vaccination
Flowers promote ovarian development and vitellogenin gene expression in Apolygus lucorum (Heteroptera: Miridae)
Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ
Genetic diversity and host relationships of endosymbiotic bacteria in the Asian cryptic species of Bemisia tabaci from Bangladesh
Production and characterization of a novel long-acting Herceptin-targeted nanobubble contrast agent specific for Her-2-positive breast cancers
VEGF111b, a C-terminal splice variant of VEGF-A and induced by mitomycin C, inhibits ovarian cancer growth
The invasive MED/Q Bemisia tabaci genome: a tale of gene loss and gene gain
Abstract Background Sweetpotato whitefly, Bemisia tabaci MED/Q and MEAM1/B, are two economically important invasive species that cause considerable damages to agriculture crops through direct feeding and indirect vectoring of plant pathogens. Recently, a draft genome of B. tabaci MED/Q has been assembled. In this study, we focus on the genomic comparison between MED/Q and MEAM1/B, with a special interest in MED/Q’s genomic signatures that may contribute to the highly invasive nature of this emerging insect pest. Results The genomes of both species share similarity in syntenic blocks, but have significant divergence in the gene coding sequence. Expansion of cytochrome P450 monooxygenases and UDP glycosyltransferases in MED/Q and MEAM1/B genome is functionally validated for mediating insecticide resistance in MED/Q using in vivo RNAi. The amino acid biosynthesis pathways in MED/Q genome are partitioned among the host and endosymbiont genomes in a manner distinct from other hemipterans. Evidence of horizontal gene transfer to the host genome may explain their obligate relationship. Putative loss-of-function in the immune deficiency-signaling pathway due to the gene loss is a shared ancestral trait among hemipteran insects. Conclusions The expansion of detoxification genes families, such as P450s, may contribute to the development of insecticide resistance traits and a broad host range in MED/Q and MEAM1/B, and facilitate species’ invasions into intensively managed cropping systems. Numerical and compositional changes in multiple gene families (gene loss and gene gain) in the MED/Q genome sets a foundation for future hypothesis testing that will advance our understanding of adaptation, viral transmission, symbiosis, and plant-insect-pathogen tritrophic interactions