13 research outputs found
Wormhole Geometries In Gravity
We study wormhole solutions in the framework of f (R,T) gravity where R is
the scalar curvature, and T is the trace of the stress-energy tensor of the
matter. We have obtained the shape function of the wormhole by specifying an
equation of state for the matter field and imposing the flaring out condition
at the throat. We show that in this modified gravity scenario, the matter
threading the wormhole may satisfy the energy conditions, so it is the
effective stress-energy that is responsible for violation of the null energy
condition.Comment: 9 pages, 4 figures, published version, references adde
Modulation of nucleic acid information processing by PNAs: potential use in anti-viral therapeutics
Targeting the State: Risks, Benefits, and Strategic Dilemmas of Recent LGBT Health Advocacy
Modelling the Human Immune System by Combining Bioinformatics and Systems Biology Approaches
Over the past decade a number of bioinformatics tools have been developed that use genomic sequences as input to predict to which parts of a microbe the immune system will react, the so-called epitopes. Many predicted epitopes have later been verified experimentally, demonstrating the usefulness of such predictions. At the same time, simulation models have been developed that describe the dynamics of different immune cell populations and their interactions with microbes. These models have been used to explain experimental findings where timing is of importance, such as the time between administration of a vaccine and infection with the microbe that the vaccine is intended to protect against. In this paper, we outline a framework for integration of these two approaches. As an example, we develop a model in which HIV dynamics are correlated with genomics data. For the first time, the fitness of wild type and mutated virus are assessed by means of a sequence-dependent scoring matrix, derived from a BLOSUM matrix, that links protein sequences to growth rates of the virus in the mathematical model. A combined bioinformatics and systems biology approach can lead to a better understanding of immune system-related diseases where both timing and genomic information are of importance
2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management
2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management
Cardiolog