26 research outputs found
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
First isolated in California, USA, in 1969, enterovirus 71 (EV71) is a major public health issue across the Asia-Pacific region and beyond. The virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complications. Specific receptors for this virus are found on white blood cells, cells in the respiratory and gastrointestinal tract, and dendritic cells. Being an RNA virus, EV71 lacks a proofreading mechanism and is evolving rapidly, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties. The pathogenesis of the severe cardiopulmonary manifestations and the relative contributions of neurogenic pulmonary oedema, cardiac dysfunction, increased vascular permeability, and cytokine storm are controversial. Public health interventions to control outbreaks involve social distancing measures, but their effectiveness has not been fully assessed. Vaccines being developed include inactivated whole-virus, live attenuated, subviral particle, and DNA vaccines
Impact of multidisciplinary tumour boards (MTB) on the clinicopathological characteristics and outcomes of resected colorectal liver metastases across time
10.1186/s12957-020-01984-8World Journal of Surgical Oncology18123
Wash-out of hepatocellular carcinoma: Quantitative region of interest analysis on CT
Annals of the Academy of Medicine Singapore406269-275AAMS
Network of clinically-relevant lncRNAs-mRNAs associated with prognosis of hepatocellular carcinoma patients
10.1038/s41598-020-67742-8Scientific Reports1011112
Correction: The Singapore Liver Cancer Recurrence (SLICER) score for relapse prediction in patients with surgically resected hepatocellular carcinoma
10.1371/journal.pone.0128058PLoS ONE105e012805
Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma
10.1038/s41598-019-46872-8Scientific Reports911046