Milagro limits and HAWC sensitivity for the rate-density of evaporating Primordial Black Holes

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Sensitivity of the high altitude water Cherenkov detector to sources of multi-TeV gamma rays

The High Altitude Water Cherenkov (HAWC) observatory is an array of large water Cherenkov detectors sensitive to gamma rays and hadronic cosmic rays in the energy band between 100 GeV and 100 TeV. The observatory will be used to measure high-energy protons and cosmic rays via detection of the energetic secondary particles reaching the ground when one of these particles interacts in the atmosphere above the detector. HAWC is under construction at a site 4100 meters above sea level on the northern slope of the volcano Sierra Negra, which is located in central Mexico at 19 N latitude. It is scheduled for completion in 2014. In this paper we estimate the sensitivity of the HAWC instrument to point-like and extended sources of gamma rays. The source fluxes are modeled using both unbroken power laws and power laws with exponential cutoffs. HAWC, in one year, is sensitive to point sources with integral power-law spectra as low as 5×10-13 cm-2sec-1 above 2 TeV (approximately 50 mCrab) over 5 sr of the sky. This is a conservative estimate based on simple event parameters and is expected to improve as the data analysis techniques are refined. We discuss known TeV sources and the scientific contributions that HAWC can make to our understanding of particle acceleration in these sources. © 2013 Elsevier B.V. All rights reserved

International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

•We report INICC device-associated module data of 50 countries from 2010-2015.•We collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.•DA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.•Device utilization ratio in the INICC ICUs was similar to CDC-NHSN's. Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days. Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs. Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically