1,186 research outputs found
CLEMENTINE: New Directions and Perspectives for One-of-a-Kind Spacecraft Missions
CLEMENTINE, the Deep Space Program Science Experiment (DSPSE), represents a new class of small and capable spacecraft that enable long-duration space missions at low cost. CLEMENTINE represents a new paradigm in spacecraft systems, i.e., advanced, lightweight, non-spaceflight and nonheritage technologies are major and critical components of the payload, the spacecraft hardware, and the spacecraft software subsystems. The program\u27s success in applying and transferring these low-cost and highly capable technologies to space applications was based on sound developmental practices that are applicable to other programs. This paper will examine the engineering and management approaches used for CLEMENTINE, discuss the methods used to assess, use, and test these technologies, and provide conclusions on the strengths and weaknesses of the development approach. The paper will provide an insight into the common elements of the development approach that may be applicable to other smallsatellite missions
Code-division multiple-access in an optical fiber LAN with amplified bus topology: the SLIM bus
A novel optical fiber network with a bus topology and dark signaling (the SLIM bus) using optical code-division multiple-access (CDMA) is proposed. With a new design of delay line correlator the network is shown to eliminate optical beating noise and overcome the main limitations of incoherent optical CDMA in a star topology
Using the stated preference method for the calculation of social discount rate
The aim of this paper is to build the stated preference method into the social discount rate methodology. The first part of the paper presents the results of a survey about stated time preferences through pair-choice decision situations for various topics and time horizons. It is assumed that stated time preferences differ from calculated time preferences and that the extent of stated rates depends on the time period, and on how much respondents are financially and emotionally involved in the transactions. A significant question remains: how can the gap between the calculation and the results of surveys be resolved, and how can the real time preferences of individuals be interpreted using a social time preference rate. The second part of the paper estimates the social time preference rate for Hungary using the results of the survey, while paying special attention to the pure time preference component. The results suggest that the current method of calculation of the pure time preference rate does not reflect the real attitudes of individuals towards future generations
Random walk through fractal environments
We analyze random walk through fractal environments, embedded in
3-dimensional, permeable space. Particles travel freely and are scattered off
into random directions when they hit the fractal. The statistical distribution
of the flight increments (i.e. of the displacements between two consecutive
hittings) is analytically derived from a common, practical definition of
fractal dimension, and it turns out to approximate quite well a power-law in
the case where the dimension D of the fractal is less than 2, there is though
always a finite rate of unaffected escape. Random walks through fractal sets
with D less or equal 2 can thus be considered as defective Levy walks. The
distribution of jump increments for D > 2 is decaying exponentially. The
diffusive behavior of the random walk is analyzed in the frame of continuous
time random walk, which we generalize to include the case of defective
distributions of walk-increments. It is shown that the particles undergo
anomalous, enhanced diffusion for D_F < 2, the diffusion is dominated by the
finite escape rate. Diffusion for D_F > 2 is normal for large times, enhanced
though for small and intermediate times. In particular, it follows that
fractals generated by a particular class of self-organized criticality (SOC)
models give rise to enhanced diffusion. The analytical results are illustrated
by Monte-Carlo simulations.Comment: 22 pages, 16 figures; in press at Phys. Rev. E, 200
Structural Evolution in a Melt-Quenched Zeolitic Imidazolate Framework Glass during Heat-treatment
There and back again: migration in freshwater fishes
Animal migration is an amazing phenomenon that has fascinated humans for long. Many freshwater fishes also show remarkable migrations, whereof the spectacular mass migrations of salmonids from the spawning streams are the most well known and well studied. However, recent studies have shown that migration occurs in a range of freshwater fish taxa from many different habitats. In this review we focus on the causes and consequences of migration in freshwater fishes. We start with an introduction of concepts and categories of migration, and then address the evolutionary causes that
drive individuals to make these migratory journeys. The basis for the decision of an individual fish to migrate or stay resident is an evaluation of the costs and benefits of different strategies to maximize its lifetime reproductive effort. We provide examples by discussing our own work on the causes behind seasonal migration in a cyprinid fish, roach (Rutilus rutilus (L., 1758)), within this framework. We then highlight different adaptations that allow fish to migrate over sometimes vast journeys across space, including capacity for orientation, osmoregulation, and efficient energy expenditure. Following this we consider the consequences of migration in freshwater fish from ecological, evolutionary, and conservation perspectives, and finally, we detail some of the recent developments in the methodologies used to collect data on fish migration and how these could be used in future research
Detection of Escherichia coli serogroups O26, O103, O111 and O145 from bovine faeces using immunomagnetic separation and PCR/DNA probe techniques
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Navier-Stokes transport coefficients of -dimensional granular binary mixtures at low density
The Navier-Stokes transport coefficients for binary mixtures of smooth
inelastic hard disks or spheres under gravity are determined from the Boltzmann
kinetic theory by application of the Chapman-Enskog method for states near the
local homogeneous cooling state. It is shown that the Navier-Stokes transport
coefficients are not affected by the presence of gravity. As in the elastic
case, the transport coefficients of the mixture verify a set of coupled linear
integral equations that are approximately solved by using the leading terms in
a Sonine polynomial expansion. The results reported here extend previous
calculations [V. Garz\'o and J. W. Dufty, Phys. Fluids {\bf 14}, 1476 (2002)]
to an arbitrary number of dimensions. To check the accuracy of the
Chapman-Enskog results, the inelastic Boltzmann equation is also numerically
solved by means of the direct simulation Monte Carlo method to evaluate the
diffusion and shear viscosity coefficients for hard disks. The comparison shows
a good agreement over a wide range of values of the coefficients of restitution
and the parameters of the mixture (masses and sizes).Comment: 6 figures, to be published in J. Stat. Phy
Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience.
BACKGROUND: Uveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody ipilimumab is a standard of care for metastatic melanoma; however, the clinical activity of CTLA-4 inhibition in patients with metastatic uveal melanoma is poorly defined.
METHODS: To assess ipilimumab in this setting, the authors performed a multicenter, retrospective analysis of 4 hospitals in the United States and Europe. Clinical characteristics, toxicities, and radiographic disease burden, as determined by central, blinded radiology review, were evaluated.
RESULTS: Thirty-nine patients with uveal melanoma were identified, including 34 patients who received 3 mg/kg ipilimumab and 5 who received 10 mg/kg ipilimumab. Immune-related response criteria and modified World Health Organization criteria were used to assess the response rate (RR) and the combined response plus stable disease (SD) rate after 12 weeks, after 23 weeks, and overall (median follow-up, 50.4 weeks [12.6 months]). At week 12, the RR was 2.6%, and the response plus SD rate was 46.%; at week 23, the RR was 2.6%, and the response plus SD rate was 28.2%. There was 1 complete response and 1 late partial response (at 100 weeks after initial SD) for an immune-related RR of 5.1%. Immune-related adverse events were observed in 28 patients (71.8%) and included 7 (17.9%) grade 3 and 4 events. Immune-related adverse events were more frequent in patients who received 10 mg/kg ipilimumab than in those who received 3 mg/kg ipilimumab. The median overall survival from the first dose of ipilimumab was 9.6 months (95% confidence interval, 6.3-13.4 months; range, 1.6-41.6 months). Performance status, lactate dehydrogenase level, and an absolute lymphocyte count â„ 1000 cells/ÎŒL at week 7 were associated significantly with survival.
CONCLUSIONS: In this multicenter, retrospective analysis of 4 hospitals in the United States and Europe of patients with uveal melanoma, durable responses to ipilimumab and manageable toxicity were observed
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