Pentoxifylline, tocopherol, and sequestrectomy are effective for the management of advanced osteoradionecrosis of the jaws—a case series

Background: The aim of the present study was to evaluate the efficacy of pentoxifylline and tocopherol for the management of osteoradionecrosis of the jaws. / Methods: Twenty-five patients diagnosed with osteoradionecrosis of the jaws treated with pentoxifylline 400 mg + tocopherol 400 mg three times daily (tid) were evaluated. Clinical records and image tests were reviewed. All patients were previously submitted to head and neck radiation therapy and presented with a clinical and radiographic diagnosis of osteoradionecrosis of the jaws. / Results: Following therapy with pentoxifylline and tocopherol, 76% (19/25) of the patients showed complete mucosal healing, in which 47.3% (9/19) did not undergo sequestrectomy. From this particular group, 77.7% (7/9) were in stage I and 33.3% (3/9) used the protocol for up to 3 months. Among those who underwent to sequestrectomy, complete mucosal healing was observed in 52.7% (10/19). Among these, 60% (6/10) were in stage I and 100% of the patients were using the protocol for more than 3 months. In all other patients, partial healing of the mucosa was observed since they presented advanced disease. These represented 24% of the sample (6/25), 66.6% (4/6) were in stage III, and 60% (4/6) used the protocol for over 6 months. / Conclusion: Pentoxifylline and tocopherol may provide effective management of osteoradionecrosis of the jaws, and the association with sequestrectomy may avoid major surgical procedures

Behaviour of displacement piles in sand under cyclic axial loading

Field experiments have demonstrated that piles driven into sand can respond to axial cyclic loading in Stable, Unstable or Meta-Stable ways, depending on the combinations of mean and cyclic loads and the number of cycles. An understanding of the three styles of responses is provided by experiments involving a highly instrumented model displacement pile and an array of soil stress sensors installed in fine sand in a pressurised calibration chamber. The different patterns of effective stress developing on and around the shaft are reported, along with the results of static load tests that track the effects on shaft capacity. The interpretation links these observations to the sand's stress strain behaviour. The interface-shear characteristics, the kinematic yielding, the local densification, the growth of a fractured interface-shear zone and the restrained dilatancy at the pile soil interface are all found to be important. The model tests are shown to be compatible with the full-scale behaviour and to provide key information for improving the modelling and the design rules. (C) 2012 The Japanese Geotechnical Society. Production and hosting by Elsevier B.V. All rights reserved.Shell U.K.Shell U.K.UK Health and Safety ExecutiveUK Health and Safety ExecutiveUK Engineering Physcial Science Research CouncilUK Engineering Physcial Science Research CouncilTotal FranceTotal FranceCentre National de la Recherche Scientifique (CNRS)Centre National de la Recherche Scientifique (CNRS)French Programme ANR SOLCYPFrench Programme ANR SOLCYPUK Royal SocietyUK Royal SocietyNatural Science Foundation of ChinaNatural Science Foundation of China [51011130162, 51178421

Fluoride in the Serra Geral Aquifer System: Source Evaluation Using Stable Isotopes and Principal Component Analysis.

Groundwater with anomalous fluoride content and water mixture patterns were studied in the fractured Serra Geral Aquifer System, a basaltic to rhyolitic geological unit, using a principal component analysis interpretation of groundwater chemical data from 309 deep wells distributed in the Rio Grande do Sul State, Southern Brazil. A four-component model that explains 81% of the total variance in the Principal Component Analysis is suggested. Six hydrochemical groups were identified. ??18O and ??2 H were analyzed in 28 Serra Geral Aquifer System samples in order to identify stable isotopes patterns and make comparisons with data from the Guarani Aquifer System and meteoric waters. The results demonstrated a complex water mixture between the Serra Geral Aquifer System and the Guarani Aquifer System, with meteoric recharge and ascending water infiltration through an intensive tectonic fracturing

The traditional knowledge on stingless bees (Apidae: Meliponina) used by the Enawene-Nawe tribe in western Brazil

<p>Abstract</p> <p>Background</p> <p>This paper presents the Enawene-Nawe Society's traditional knowledge about stingless bees. The Enawene-Nawe are an Aruak speaking people, indigenous to the Meridian Amazon. Specifically, they live in the Jurema River hydrological basin, located in the northwestern region of the Mato Grosso state.</p> <p>Methods</p> <p>The stingless bees were sampled from two ecologically similar regions in the interior of Enawene-Nawe Land. The first sampling took place around the village, i.e., adjacent to houses, by the edge of the Iquê River, next to food leftovers, around human excrement, and simply when the insects were found flying or reposing on a human body. The second round of sampling happened from 29/10 to 02/11/94, during an expedition for honey collection that took place throughout the ciliar bushes of the Papagaio River, an important tributary of Juruena River. We sampled bees adjacent to their nests following the beehive inspection or during the honey extraction.</p> <p>In this work, the main bee species of the sub tribe Meliponina, which were handled by the Enawene-Nawe, was identified, and a brief ethnographic description of the honey collection expeditions and its social-cosmologic meaning for the group was done.</p> <p>Results and Discussion</p> <p>Similar to other indigenous people in Brazil, the Enawene-Nawe recognized 48 stingless bee species. They identified each bee species by name and specified each one's ecological niche. A brief ethnographic description of the honey collection expeditions and bees' social-cosmologic meaning for the group is included.</p> <p>Conclusion</p> <p>We concluded that, as an example of other indigenous people, the Enawene-Nawe classify and identify the bees based not only on their structure and morphological aspects but also on the ecological, etiological, and social characteristics of the species.</p

Lepton Flavor Violation and the Origin of the Seesaw Mechanism

The right--handed neutrino mass matrix that is central to the understanding of small neutrino masses via the seesaw mechanism can arise either (i) from renormalizable operators or (ii) from nonrenormalizable or super-renormalizable operators, depending on the symmetries and the Higgs content of the theory beyond the Standard Model. In this paper, we study lepton flavor violating (LFV) effects in the first class of seesaw models wherein the \nu_R Majorana masses arise from renormalizable Yukawa couplings involving a B-L = 2 Higgs field. We present detailed predictions for \tau -> \mu + \gamma and \mu -> e + \gamma branching ratios in these models taking the current neutrino oscillation data into account. Focusing on minimal supergravity models, we find that for a large range of MSSM parameters suggested by the relic abundance of neutralino dark matter and that is consistent with Higgs boson mass and other constraints, these radiative decays are in the range accessible to planned experiments. We compare these predictions with lepton flavor violation in the second class of models arising entirely from the Dirac Yukawa couplings. We study the dependence of the ratio r \equiv B(\mu -> e+\gamma)/B(\tau ->\mu +\gamma) on the MSSM parameters and show that measurement of r can provide crucial insight into the origin of the seesaw mechanism.Comment: 20 pages, Revtex, 7 figure