The Near-Threshold Production of Phi Mesons in pp Collisions

The pp->pp phi reaction has been studied at the Cooler Synchrotron COSY-Juelich, using the internal beam and ANKE facility. Total cross sections have been determined at three excess energies epsilon near the production threshold. The differential cross section closest to threshold at epsilon=18.5 MeV exhibits a clear S-wave dominance as well as a noticeable effect due to the proton-proton final state interaction. Taken together with data for pp omega-production, a significant enhancement of the phi/omega ratio of a factor 8 is found compared to predictions based on the Okubo-Zweig-Iizuka rule.Comment: 4 Pages, 3 Figures, 1 Table, submitted to Phys. Rev. Let

a0+(980)-resonance production in pp->dK+Kbar0 reactions close to threshold

The reaction pp->d K+ Kbar0 has been investigated at an excess energy of Q=46 MeV above the (K+ Kbar0) threshold with ANKE at COSY-Juelich. From the detected coincident dK+ pairs about 1000 events with a missing Kbar0 were identified, corresponding to a total cross section of sigma(pp->d K+ Kbar0)=(38 +/- 2(stat) +/- 14(syst)) nb. Invariant-mass and angular distributions have been jointly analyzed and reveal s-wave dominance between the two kaons, accompanied by a p-wave between the deuteron and the kaon system. This is interpreted in terms of a0+(980)-resonance production.Comment: 4 pages, 4 figures; accepted by Phys. Rev. Let

Integrity of H1 helix in prion protein revealed by molecular dynamic simulations to be especially vulnerable to changes in the relative orientation of H1 and its S1 flank

In the template-assistance model, normal prion protein (PrPC), the pathogenic cause of prion diseases such as Creutzfeldt-Jakob (CJD) in human, Bovine Spongiform Encephalopathy (BSE) in cow, and scrapie in sheep, converts to infectious prion (PrPSc) through an autocatalytic process triggered by a transient interaction between PrPC and PrPSc. Conventional studies suggest the S1-H1-S2 region in PrPC to be the template of S1-S2 $\beta$-sheet in PrPSc, and the conformational conversion of PrPC into PrPSc may involve an unfolding of H1 in PrPC and its refolding into the $\beta$-sheet in PrPSc. Here we conduct a series of simulation experiments to test the idea of transient interaction of the template-assistance model. We find that the integrity of H1 in PrPC is vulnerable to a transient interaction that alters the native dihedral angles at residue Asn$^{143}$, which connects the S1 flank to H1, but not to interactions that alter the internal structure of the S1 flank, nor to those that alter the relative orientation between H1 and the S2 flank.Comment: A major revision on statistical analysis method has been made. The paper now has 23 pages, 11 figures. This work was presented at 2006 APS March meeting session K29.0004 at Baltimore, MD, USA 3/13-17, 2006. This paper has been accepted for pubcliation in European Biophysical Journal on Feb 2, 200

Latest Developments from the S-DALINAC*

The S-DALINAC is a 130 MeV superconducting recirculating electron accelerator serving several nuclear and radiation physics experiments as well as driving an infrared free-electron laser. A system of normal conducting rf resonators for noninvasive beam position and current measurement was established. For the measurement of gamma-radiation inside the accelerator cave a system of Compton diodes has been developed and tested. Detailed investigations of the transverse phasespace were carried out with a tomographical reconstruction method of optical transition radiation spots. The method can be applied also to non-Gaussian phasespace distributions. The results are in good accordance with simulations. To improve the quality factor of the superconducting 3 GHz cavities, an external 2K testcryostat was commissioned. The influence of electro-chemical polishing and magnetic shielding is currently under investigation. A digital rf-feedback-system for the accelerator cavities is being developed in order to improve the energy spread of the beam of the S-DALINAC. * Supported by the BMBF under contract no. 06 DA 820, the DFG under contract no. Ri 242/12-1 and -2 and the DFG Graduiertenkolleg 'Physik und Technik von Beschleunigern

Forward K+ production in subthreshold pA collisions at 1.0 GeV

K+ meson production in pA (A = C, Cu, Au) collisions has been studied using the ANKE spectrometer at an internal target position of the COSY-Juelich accelerator. The complete momentum spectrum of kaons emitted at forward angles, theta < 12 degrees, has been measured for a beam energy of T(p)=1.0 GeV, far below the free NN threshold of 1.58 GeV. The spectrum does not follow a thermal distribution at low kaon momenta and the larger momenta reflect a high degree of collectivity in the target nucleus.Comment: 4 pages, 3 figure

a0+(980)-resonance production in the reaction pp -> dpi+eta close to the K(bar(K)) threshold

The reaction pp -> dpi+eta has been measured at a beam energy of T=2.65 GeV (p=3.46 GeV/c) using the ANKE spectrometer at COSY-Juelich. The missing mass distribution of the detected dpi+ pairs exhibits a peak around the eta mass on top of a strong background of multi-pion pp -> dpi+(n(pi)) events. The differential cross section d^4(sigma)/d(Omega_d)d(Omega_pi+)d(p_d)d(p_pi+) for the reaction pp -> dpi+eta has been determined model independently for two regions of phase space. Employing a dynamical model for the a0+ production allows one then to deduce a total cross section of sigma(pp -> da0+ -> dpi+eta)=(1.1 +/- 0.3_(stat) +/- 0.7_(syst)) microbarn for the production of pi+eta via the scalar a0+(980) resonance and sigma(pp -> dpi+eta) = (3.5 +/- 0.3_(stat) +/- 1.0_(syst)) microbarn for the non-resonant production. Using the same model as for the interpretation of recent results from ANKE for the reaction pp -> dK+(bar(K0)), the ratio of the total cross sections is sigma(pp -> d(K+(bar(K0)))_(L=0))/sigma(pp -> da0+ -> dpi+eta) = 0.029 +/- 0.008_(stat) +/- 0.009_(syst), which is in agreement with branching ratios in the literature.Comment: 5 pages, 8 figures, 1 tabl

Promoting remyelination in multiple sclerosis-recent advances

We review the current state of knowledge of remyelination in multiple sclerosis (MS), concentrating on advances in the understanding of the pathology and the regenerative response, and we summarise progress on the development of new therapies to enhance remyelination aimed at reducing progressive accumulation of disability in MS. We discuss key target pathways identified in experimental models, as although most identified targets have not yet progressed to the stage of being tested in human clinical trials, they may provide treatment strategies for demyelinating diseases in the future. Finally, we discuss some of the problems associated with testing this class of drugs, where they might fit into the therapeutic arsenal and the gaps in our knowledge