Computer aids and human second reading as interventions in screening mammography: two systematic reviews to compare effects on cancer detection and recall rate

Background: There are two competing methods for improving the accuracy of a radiologist interpreting screening mammograms: computer aids (CAD) or independent second reading. Methods: Bibliographic databases were searched for clinical trials. Meta-analyses estimated impacts of CAD and double reading on odds ratios for cancer detection and recall rates. Sub-group analyses considered double reading with arbitration. Results: Ten studies compared single reading with CAD to single reading. Seventeen compared double to single reading. Double reading increases cancer detection and recall rates. Double reading with arbitration increases detection rate (CI: 1.02-1.15) and decreases recall rate (CI: 0.92-0.96). CAD does not have a significant effect on cancer detection rate (CI: 0.96-1.13) and increases recall rate (95% CI: 1.09-1.12). However, there is considerable heterogeneity in the impact on recall rate in both sets of studies. Conclusion: The evidence that double reading with arbitration enhances screening is stronger than that for single reading with CAD

Spectral properties of the tandem Jackson network, seen as a quasi-birth-and-death process

Quasi-birth-and-death (QBD) processes with infinite ``phase spaces'' can exhibit unusual and interesting behavior. One of the simplest examples of such a process is the two-node tandem Jackson network, with the ``phase'' giving the state of the first queue and the ``level'' giving the state of the second queue. In this paper, we undertake an extensive analysis of the properties of this QBD. In particular, we investigate the spectral properties of Neuts's R-matrix and show that the decay rate of the stationary distribution of the ``level'' process is not always equal to the convergence norm of R. In fact, we show that we can obtain any decay rate from a certain range by controlling only the transition structure at level zero, which is independent of R. We also consider the sequence of tandem queues that is constructed by restricting the waiting room of the first queue to some finite capacity, and then allowing this capacity to increase to infinity. We show that the decay rates for the finite truncations converge to a value, which is not necessarily the decay rate in the infinite waiting room case. Finally, we show that the probability that the process hits level n before level 0 given that it starts in level 1 decays at a rate which is not necessarily the same as the decay rate for the stationary distribution.Comment: Published at http://dx.doi.org/10.1214/105051604000000477 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org

Large area application of a corn hazard model

An application test of the crop calendar portion of a corn (maize) stress indicator model developed by the early warning, crop condition assessment component of AgRISTARS was performed over the corn for grain producing regions of the U.S.S.R. during the 1980 crop year using real data. Performance of the crop calendar submodel was favorable; efficiency gains in meteorological data analysis time were on a magnitude of 85 to 90 percent

Knowledge management: Using a knowledge requirements framework to enhance UK health sector supply chains

The gaps of mismatch both knowledge and understanding of beneficiaries and solution providers at the initial stage of developing projects have led to the failures of many projects including supply chains (SC) and related information technology systems (ITS) projects (Lyytinen and Hirschheim, 1987) . The aims of this paper are first, to address theoretical framework by bridging the gaps of different types of knowledge. Second, to establishing business requirements and the flow of information in supply chains between beneficiaries and solution providers in the long and complicated supply chains of the UK’s Health Sector. On the basis of brief introduction to knowledge, knowledge management and supply chain, the paper presents a practical framework that has been developed through critical and relevant literatures in the above three subject areas. Techniques and Tools stem from both management science and information systems were used to provide a possible solution for the problem in bridging the gaps of mismatch knowledge and understanding at the initial stage of identifying requirements in projects through knowledge sharing and transfer

Cylindrical Crystal Imaging Spectrometer (CCIS) for cosmic X-ray spectroscopy

A "stigmatic" focusing, Bragg crystal spectrometer was developed and used for high spectral resolution X-ray emission line diagnostics on hot laboratory plasmas. The concept be applied at the focal plane of an orbiting X-ray telescope where it offers several advantages over conventional spectrometers, i.e., mechanical simplicity, high resolving power and sensitivity, simultaneous measurement of an extended segment of spectrum, and good imaging properties. The instrument features a simple, unambiguous, non-scanning spectrum readout that is not adversely affected by either spacecraft pointing error or source extent. The performance of the instrument is estimated in the context of the Advanced X-Ray Astrophysical Facility mission

Configuration Analysis Tool (CAT). System Description and users guide (revision 1)

A system description of, and user's guide for, the Configuration Analysis Tool (CAT) are presented. As a configuration management tool, CAT enhances the control of large software systems by providing a repository for information describing the current status of a project. CAT provides an editing capability to update the information and a reporting capability to present the information. CAT is an interactive program available in versions for the PDP-11/70 and VAX-11/780 computers

Benchmark full configuration-interaction calculations on H2O, F- and F

Full configuration-interaction calculations are reported, and compared to other methods, for H2O at its equilibrium geometry and at two geometries with the H-O bonds stretched. Since the percentage of the self-consistent field (SCF) reference in the full configuration-interaction (FCI) wave function decreases greatly with the bond elongation, the accuracy of techniques based on a single reference do not compare well with the FCI results. However, the results from a complete active space SCF/multireference configuration-interaction (CASSCF/MRCI) treatment are in good agreement with the FCI. Correlation effects in F compared to Ne are far more similar than for F- compared to Ne, despite F- and Ne being isoelectronic. Since the importance of higher than double excitations is more important for F- than F, a very high percentage of the correlation must be obtained to accurately compute the electron affinity. In a CASSCF/MRCI treatment the higher than quadruple excitations contribute 0.02 eV to the electron affinity (EA), even for modest basis sets

A perturbative analysis of tachyon condensation

Tachyon condensation in the open bosonic string is analyzed using a perturbative expansion of the tachyon potential around the unstable D25-brane vacuum. Using the leading terms in the tachyon potential, Pad\'e approximants can apparently give the energy of the stable vacuum to arbitrarily good accuracy. Level-truncation approximations up to level 10 for the coefficients in the tachyon potential are extrapolated to higher levels and used to find approximants for the full potential. At level 14 and above, the resulting approximants give an energy less than -1 in units of the D25-brane tension, in agreement with recent level-truncation results by Gaiotto and Rastelli. The extrapolated energy continues to decrease below -1 until reaching a minimum near level 26, after which the energy turns around and begins to approach -1 from below. Within the accuracy of this method, these results are completely consistent with an energy which approaches -1 as the level of truncation is taken to be arbitrarily large.Comment: 8 pages, 3 eps figures, Latex; v2: typo correcte

Investigation of the influence of a step change in surface roughness on turbulent heat transfer

The use is studied of smooth heat flux gages on the otherwise very rough SSME fuel pump turbine blades. To gain insights into behavior of such installations, fluid mechanics and heat transfer data were collected and are reported for a turbulent boundary layer over a surface with a step change from a rough surface to a smooth surface. The first 0.9 m length of the flat plate test surface was roughened with 1.27 mm hemispheres in a staggered, uniform array spaced 2 base diameters apart. The remaining 1.5 m length was smooth. The effect of the alignment of the smooth surface with respect to the rough surface was also studied by conducting experiments with the smooth surface aligned with the bases or alternatively with the crests of the roughness elements. Stanton number distributions, skin friction distributions, and boundary layer profiles of temperature and velocity are reported and are compared to previous data for both all rough and all smooth wall cases. The experiments show that the step change from rough to smooth has a dramatic effect on the convective heat transfer. It is concluded that use of smooth heat flux gages on otherwise rough surfaces could cause large errors