Cosmology of Axions and Moduli: A Dynamical Systems Approach

This paper is concerned with string cosmology and the dynamics of multiple scalar fields in potentials that can become negative, and their features as (Early) Dark Energy models. Our point of departure is the "String Axiverse", a scenario that motivates the existence of cosmologically light axion fields as a generic consequence of string theory. We couple such an axion to its corresponding modulus. We give a detailed presentation of the rich cosmology of such a model, ranging from the setting of initial conditions on the fields during inflation, to the asymptotic future. We present some simplifying assumptions based on the fixing of the axion decay constant $f_a$, and on the effective field theory when the modulus trajectory is adiabatic, and find the conditions under which these assumptions break down. As a by-product of our analysis, we find that relaxing the assumption of fixed $f_a$ leads to the appearance of a new meta-stable de-Sitter region for the modulus without the need for uplifting by an additional constant. A dynamical systems analysis reveals the existence of many fixed point attractors, repellers and saddle points, which we analyse in detail. We also provide geometric interpretations of the phase space. The fixed points can be used to bound the couplings in the model. A systematic scan of certain regions of parameter space reveals that the future evolution of the universe in this model can be rich, containing multiple epochs of accelerated expansion.Comment: 27 pages, 12 figures, comments welcome, v2 minor correction

The Millennium Galaxy Catalogue: morphological classification and bimodality in the colour-concentration plane

Using 10 095 galaxies (B < 20 mag) from the Millennium Galaxy Catalogue, we derive B-band luminosity distributions and selected bivariate brightness distributions for the galaxy population. All subdivisions extract highly correlated sub-sets of the galaxy population which consistently point towards two overlapping distributions. A clear bimodality in the observed distribution is seen in both the rest-(u-r) colour and log(n) distributions. The rest-(u-r) colour bimodality becomes more pronounced when using the core colour as opposed to global colour. The two populations are extremely well separated in the colour-log(n) plane. Using our sample of 3 314 (B < 19 mag) eyeball classified galaxies, we show that the bulge-dominated, early-type galaxies populate one peak and the bulge-less, late-type galaxies occupy the second. The early- and mid-type spirals sprawl across and between the peaks. This constitutes extremely strong evidence that the fundamental way to divide the luminous galaxy population is into bulges and discs and that the galaxy bimodality reflects the two component nature of galaxies and not two distinct galaxy classes. We argue that these two-components require two independent formation mechanisms/processes and advocate early bulge formation through initial collapse and ongoing disc formation through splashback, infall and merging/accretion. We calculate the B-band luminosity-densities and stellar-mass densities within each subdivision and estimate that the z ~ 0 stellar mass content in spheroids, bulges and discs is 35 +/- 2 per cent, 18 +/- 7 and 47 +/- 7 per cent respectively. [Abridged]Comment: Accepted for publication in MNRAS, 23 pages, 17 figures. Comments welcome. MGC website is at: http://www.eso.org/~jliske/mgc

Quantifying extreme behaviour in geomagnetic activity

Understanding the extremes in geomagnetic activity is an important component in understanding just how severe conditions can become in the terrestrial space environment. Extreme activity also has consequences for technological systems. On the ground, extreme geomagnetic behavior has an impact on navigation and position accuracy and the operation of power grids and pipeline networks. We therefore use a number of decades of one-minute mean magnetic data from magnetic observatories in Europe, together with the technique of extreme value statistics, to provide a preliminary exploration of the extremes in magnetic field variations and their one-minute rates of change. These extremes are expressed in terms of the variations that might be observed every 100 and 200 years in the horizontal strength and in the declination of the field. We find that both measured and extrapolated extreme values generally increase with geomagnetic latitude (as might be expected), though there is a marked maximum in estimated extreme levels between about 53 and 62 degrees north. At typical midlatitude European observatories (55–60 degrees geomagnetic latitude), compass variations may reach approximately 3–8 degrees/minute, and horizontal field changes may reach 1000–4000 nT/minute, in one magnetic storm once every 100 years. For storm return periods of 200 years the equivalent figures are 4–11 degrees/minute and 1000–6000 nT/minute

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease. Pancreaticoduodenectomy offers patients the possibility of a cure, but most will die of recurrent or metastatic disease. Hence, preventing metastatic disease in these patients would be of significant benefit. Using principal component analysis (PCA), we identified a LOX/hypoxia signature associated with poor patient survival in resectable patients. We found that LOX expression is upregulated in metastatic tumors from Pdx1‐Cre KrasG12D/+ Trp53R172H/+ (KPC) mice and that inhibition of LOX in these mice suppressed metastasis. Mechanistically, LOX inhibition suppressed both migration and invasion of KPC cells. LOX inhibition also synergized with gemcitabine to kill tumors and significantly prolonged tumor‐free survival in KPC mice with early‐stage tumors. This was associated with stromal alterations, including increased vasculature and decreased fibrillar collagen, and increased infiltration of macrophages and neutrophils into tumors. Therefore, LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies and targeting LOX could improve outcome in surgically resectable disease

Dressed Bose-Einstein Condensates in High-Q Cavities

We propose and analyze a way in which effective multicomponent condensates can be created inside high-Q multimode cavities. In contrast to the situation involving several atomic species or levels, the coupling between the various components of the dressed condensates is linear. We predict analytically and numerically confirm the onset of instabilities in the quasiparticle excitation spectrum.Comment: plain tex, 20 pages, 4 figure

General Solutions for Tunneling of Scalar Fields with Quartic Potentials in de Sitter Space

The tunneling rates for scalar fields with quartic potentials in de Sitter space in the limit of no gravitational back reaction are calculated numerically and the results are fitted by analytic formulae.Comment: (Contours in Figure 1 corrected, two-dimensional fitting coefficient corrected, references added.), 16 pages, KUNS 124

Structural analysis of X-Linked Retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function

Retinoschisin, an octameric retinal-specific protein, is essential for retinal architecture with mutations causing X-linked retinoschisis (XLRS), a monogenic form of macular degeneration. Most XLRS-associated mutations cause intracellular retention, however a subset are secreted as octamers and the cause of their pathology is ill-defined. Therefore, here we investigated the solution structure of the retinoschisin monomer and the impact of two XLRS-causing mutants using a combinatorial approach of biophysics and cryo-EM. The retinoschisin monomer has an elongated structure which persists in the octameric assembly. Retinoschisin forms a dimer of octamers with each octameric ring adopting a planar propeller structure. Comparison of the octamer with the hexadecamer structure indicated little conformational change in the retinoschisin octamer upon dimerization, suggesting that the octamer provides a stable interface for construction of the hexadecamer. The H207Q XLRS-associated mutation was found in the interface between octamers and destabilized both monomeric and octameric retinoschisin. Octamer dimerization is consistent with the adhesive function of retinoschisin supporting interactions between retinal cell layers, so disassembly would prevent structural coupling between opposing membranes. In contrast, cryo-EM structural analysis of the R141H mutation at ~4.2Å resolution was found to only cause a subtle conformational change in the propeller tips, potentially perturbing an interaction site. Together, these findings support distinct mechanisms of pathology for two classes of XLRS-associated mutations in the retinoschisin assembly

General Relativistic Effects in the Core Collapse Supernova Mechanism

We apply our recently developed code for spherically symmetric, fully general relativistic (GR) Lagrangian hydrodynamics and multigroup flux-limited diffusion neutrino transport to examine the effects of GR on the hydrodynamics and transport during collapse, bounce, and the critical shock reheating phase of core collapse supernovae. Comparisons of models computed with GR versus Newtonian hydrodynamics show that collapse to bounce takes slightly less time in the GR limit, and that the shock propagates slightly farther out in radius before receding. After a secondary quasistatic rise in the shock radius, the shock radius declines considerably more rapidly in the GR simulations than in the corresponding Newtonian simulations. During the shock reheating phase, core collapse computed with GR hydrodynamics results in a substantially more compact structure from the center out to the stagnated shock. The inflow speed of material behind the shock is also increased. Comparisons also show that the luminosity and rms energy of any neutrino flavor during the shock reheating phase increases when switching from Newtonian to GR hydrodynamics, and decreases when switching from Newtonian to GR transport. This latter decrease in neutrino luminosities and rms energies is less in magnitude than the increase that arise when switching from Newtonian to GR hydrodynamics, with the result that a fully GR simulation gives higher neutrino luminosities and harder neutrino spectra than a fully Newtonian simulation of the same precollapse model.Comment: 35 pages, 23 figure

Treating Solar Model Uncertainties: A Consistent Statistical Analysis of Solar Neutrino Models and Data

We describe how to consistently incorporate solar model uncertainties, along with experimental errors and correlations, when analyzing solar neutrino data to derive confidence limits on parameter space for proposed solutions of the solar neutrino problem. Our work resolves ambiguities and inconsistencies in the previous literature. As an application of our methods we calculate the masses and mixing angles allowed by the current data for the proposed MSW solution using both Bayesian and frequentist methods, allowing purely for solar model flux variations, to compare with previous work. We consider the effects of including metal diffusion in the solar models and also discuss implications for future experiments.Comment: 29 pages (incl figs), latex, 6 figures (appended as separate uuencoded file. To embed figures in text, uncomment 6 \epsfysize lines which appear before bibliography), CWRU-P5-94, CfPA-94-TTH-29, Fermilab-Pub-94/176-