Identification of novel single nucleotide polymorphism (SNP) in DPB1 gene in ethnic population from West Bengal

HLA-DP antigens present peptides to CD4+ T cells and play an important role in autoimmune diseases and parasitic infections. We have sequenced HLA-DPB1 exon-2 from the ethnic populations in West Bengal, India and report a novel single nucleotide polymorphism (SNP) - rs111221466. The rs111221466 SNP induced silent mutation from CGA (Arg) to TGA (Stop Codon) and showed a frequency of 83.24%. In conventional sense, the frequency of novel SNP is very high. We have sequenced HLA-DPB1 exon-2 from a Bengali Population in West Bengal, India. HLA-DP antigens present peptides to CD4+ T cells and play an important role in autoimmune diseases and parasitic infections. Here, we report a novel single nucleotide polymorphism of HLA-DPB1 gene in the population. rs111221466 showed a frequency of 83.24, which is important to note, in view of common polymorphisms involved in disease susceptibility

Population structure and genetic differentiation among the substructured Vysya caste population in comparison to the other populations of Andhra Pradesh, India

The present paper focuses on the study of the patterns of genetic microdifferentiation among one of the substructured caste populations of Andhra Pradesh, namely Vysya, with reference to 17 other Telugu speaking populations from the same region of India. A total of 302 individuais from the three Vysya subgroups (101 of Arya Vysya, 100 from Kalinga Vysya and 101 from Thrivarnika) were typed in 17 blood groups and protein polymorphisms. Nei's gene diversity analysis, as well as neighbour-joining tree and UPGMA cluster diagrams, derived from standard genetic distances, R-matrix analysis and a regression model for investigating the patterns of external gene flow and genetic drift due to isolation under the island model, were done at two levels: (1) considering only the three Vysya populations and (2) considering common loci among 20 populations of Andhra Pradesh. Seven of the 17 systems investigated were found to be monomorphic among all the three Vysya groups. The UPGMA tree and bidimensional scaling of the D2 distances derived from R-matrix analysis show a very distinct cluster of Vysya populations. Application of the model of regression of average heterozygosity versus the distance of populations from the centroid shows the three Vysya populations placed as clear outliers above the theoretical regression line. Different approaches employed in this study give support to the hypothesis of different origin and/or demographic story for the three Vysya groups compared with other populations of Andhra Pradesh.Fil: Lakshmi, N.. Andhra University; IndiaFil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; ArgentinaFil: Veerraju, P.. Andhra University; IndiaFil: Rao, T. V.. Andhra University; Indi

Opportunity for natural selection among three endogamous subpopulations of Andhra Pradesh

The Crow′s index of opportunity for natural selection has been calculated for three endogamous subpopulations namely Arya Vysya, Thrivarnika and Kalinga Vysya of North Coastal Andhra Pradesh. The total index is in the order Arya Vysya > Thrivarnika > Kalinga Vysya. However, the mortality component is more in Kalinga Vysya, reflecting the poor medical facilities available to them due to their low socio- economic profile compared to other two populations. The results of the present study are compared with those among the other caste populations of Andhra Pradesh

Selection intensity among Kshatriyas an endogamous population of Andhra Pradesh

Opportunity for natural selection has been studied among the women of Kshatriya caste population from rural and urban areas of north coastal Andhra Pradesh. The urbanrural difference for different demographic characteristics is not significant. The contribution of fertility component for both Crow's index and Jonston and Kensinger's index is more. The present study is compared with other Andhra populations. The decreased mortality differentials in Kshatriyas suggest that this component was directly affected by the better socio-economic level and reflects on the population's transitional phase

Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India

We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype, 2 to a Cameroon haplotype, and 3 to rare haplotypes. This is the first report of a Bantu haplotype in an Indian population. Some information on haplotype characteristics of normal chromosomes (HBB*A) is also presented. The average hemoglobin level was 7.3 g% and mean fetal hemoglobin (HbF) level was 12.6%. The higher HbF levels corroborate earlier observations in sickle cell homozygotes from India. Clinical investigations have revealed splenomegaly and painful crises as the most common features in these patients

Blood group and serum protein polymorphisms in Turpu Kapu population of Vizianagaram District, Andhra Pradesh

Data on two blood group and three serum protein polymorphisms of the Turpu Kapu, an endogamous population of Vizianagaram District, Andhra Pradesh (AP) is presented. The gene frequencies for the blood group systems ABO and Rh are within the ranges of distribution reported earlier among the caste populations of Andhra Pradesh. The study population shows highest frequency of Hp1 allele and the lowest frequency of Hp2 allele compared to the other populations of AP. The Cp system is monomorphic, all individuals being the BB type. The GC system exhibits polymorphism with the gene frequencies of GC1 and GC2 alleles showing the highest and lowest frequencies, respectively, as compared to the caste populations reported earlier. The χ2 test suggest that this population is in Hardy-Weinberg Equilibrium

Short Communication - Study of Some Genetic Markers in Sishta Karanam Population, Andhra Pradesh, India

A total of 76 individuals belonging to Sishta Karanam population, Andhra Pradesh, were tested for polymorphism in ABO and Rh (D) blood groups, two serum proteins, Haptoglobin and Ceruloplasmin, and one red cell enzyme, Glyoxalase-I. All the systems except Caeruloplasmin showed polymorphism. The frequency of AB phenotype is found to be highest in the Sishta Karanam when compared to the other caste populations of Andhra Pradesh so far studied. It was observed that the ABO system was not in Hardy-Weinberg Equillibrium. The Hp1-1 phenotype was absent in this population. The Glyoxalase-I locus showed all the 3 phenotypes

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Not AvailableSafflower (Carthamus tinctorius L.) is a multi-purpose oilseed crop grown for vegetable oil, animal feed, natural dyes and medicinal uses globally (Knowles 1989; Li and Mündel 1996). It is a traditional oilseed crop of India, primarily known for its healthy cooking oil containing more than 80% of polyunsaturated fatty acid (PUFA), the highest among edible oils (Kostik et al. 2012). Despite economic importance, safflower cultivation is declining in India, from 10 lakh ha. in 1988 to 1.5 lakh ha. in 2013 (FAOSTAT 2013). Seed oil content in the popular cultivars remains low (~28-32%), which is a concern for increasing the profitability of safflower cultivation. Increase of oil content in the cultivar would eventually lead to increase in oil yield, which would make safflower a commercially competitive crop for the farmers and attract the vegetable oil industry to take up safflower promotion in the country. We are exploring various strategies including the introduction of exotic high oil germplasm/varieties, conventional and molecular breeding to enhance oil content coupled with high seed yield in safflower.Not Availabl