Identification of novel single nucleotide polymorphism (SNP) in DPB1 gene in ethnic population from West Bengal

HLA-DP antigens present peptides to CD4+ T cells and play an important role in autoimmune diseases and parasitic infections. We have sequenced HLA-DPB1 exon-2 from the ethnic populations in West Bengal, India and report a novel single nucleotide polymorphism (SNP) - rs111221466. The rs111221466 SNP induced silent mutation from CGA (Arg) to TGA (Stop Codon) and showed a frequency of 83.24%. In conventional sense, the frequency of novel SNP is very high. We have sequenced HLA-DPB1 exon-2 from a Bengali Population in West Bengal, India. HLA-DP antigens present peptides to CD4+ T cells and play an important role in autoimmune diseases and parasitic infections. Here, we report a novel single nucleotide polymorphism of HLA-DPB1 gene in the population. rs111221466 showed a frequency of 83.24, which is important to note, in view of common polymorphisms involved in disease susceptibility

Population structure and genetic differentiation among the substructured Vysya caste population in comparison to the other populations of Andhra Pradesh, India

The present paper focuses on the study of the patterns of genetic microdifferentiation among one of the substructured caste populations of Andhra Pradesh, namely Vysya, with reference to 17 other Telugu speaking populations from the same region of India. A total of 302 individuais from the three Vysya subgroups (101 of Arya Vysya, 100 from Kalinga Vysya and 101 from Thrivarnika) were typed in 17 blood groups and protein polymorphisms. Nei's gene diversity analysis, as well as neighbour-joining tree and UPGMA cluster diagrams, derived from standard genetic distances, R-matrix analysis and a regression model for investigating the patterns of external gene flow and genetic drift due to isolation under the island model, were done at two levels: (1) considering only the three Vysya populations and (2) considering common loci among 20 populations of Andhra Pradesh. Seven of the 17 systems investigated were found to be monomorphic among all the three Vysya groups. The UPGMA tree and bidimensional scaling of the D2 distances derived from R-matrix analysis show a very distinct cluster of Vysya populations. Application of the model of regression of average heterozygosity versus the distance of populations from the centroid shows the three Vysya populations placed as clear outliers above the theoretical regression line. Different approaches employed in this study give support to the hypothesis of different origin and/or demographic story for the three Vysya groups compared with other populations of Andhra Pradesh.Fil: Lakshmi, N.. Andhra University; IndiaFil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; ArgentinaFil: Veerraju, P.. Andhra University; IndiaFil: Rao, T. V.. Andhra University; Indi

Insertion/Deletion Polymorphisms in Indian Tribal Populations

Five Alu markers (Alu APO, PV 92, TPA 25, D1 and ACE) were studied in five tribal populations namely, Konda Reddi, Koya Dora and Konda Kammara of East Godavari district, Lambada and Chenchu of Mahaboobnagar district of Andhra Pradesh. All the five loci were found to be highly polymorphic. While the lowest heterozygosity was observed in the Chenchu the Lambadi shows the highest. Both Neighbour Joining tree and Principal Component analysis based on genetic distances suggest two broad clusters, one formed by the Lambada and Chenchu and the other by the Konda Reddi and Koya Dora with Konda Kammara as an outer element to this three-point cluster. Another cluster analysis carried out along with 19 other Indian populations brings out no distinct cluster of the 5 AP tribes; instead these AP tribal populations are integrated into different subclusters of the UP and Bengal suggesting lack of distinct genetic identity of these AP tribes as far as the few Alu markers are concerned.Fil: Veerraju, P.. Andhra University; IndiaFil: Demarchi, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; ArgentinaFil: Lakshmi, N.. Andhra University; IndiaFil: Venkateswara Rao, T.. Andhra University; Indi

Opportunity for natural selection among three endogamous subpopulations of Andhra Pradesh

The Crow′s index of opportunity for natural selection has been calculated for three endogamous subpopulations namely Arya Vysya, Thrivarnika and Kalinga Vysya of North Coastal Andhra Pradesh. The total index is in the order Arya Vysya > Thrivarnika > Kalinga Vysya. However, the mortality component is more in Kalinga Vysya, reflecting the poor medical facilities available to them due to their low socio- economic profile compared to other two populations. The results of the present study are compared with those among the other caste populations of Andhra Pradesh