A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila

This work was funded by grants from INSERM and a 3-year Ph.D. funding from the Association Française contre les Myopathies (AFM) for H.B (Doctoral funding n°19408) and from ANR (17-CE37-0019) for T.J.Interneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other animals, limiting our understanding of the principles underlying neuronal circuit organization and function. Here we characterize a restricted subset of neurons in the nerve cord expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ+ neurons are highly diverse and selective activation of these different subtypes disrupts larval body posture and induces specific locomotor behaviors. Finally, we show that a small subset of TJ+ GABAergic INs, singled out by the expression of a unique transcription factors code, controls larval crawling speed.Publisher PDFPeer reviewe

RÔLE DES SURRÉNALES MATERNELLES DANS LA PRODUCTION D'ŒSTROGÈNES PAR LA TRUIE GRAVIDE

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Influence d'un déficit ou d'un déséquilibre alimentaire en acides aminés pendant une phase initiale de la croissance sur les performances du porc en finition

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Self-fulfilling prophecies of the European <i>knowledge-based bio-economy</i>: the discursive shaping of institutional and policy frameworks in the bio-pharmaceuticals sector

Discourses matter. They help to shape institutions and policies. A new discourse has emerged in recent EU innovation policy centred on the idea of a knowledge-based bio-economy (KBBE). It is officially defined as ‘the sustainable, eco-efficient transformation of renewable biological resources into health, food, energy and other industrial products.’ The KBBE agenda links current problem diagnoses, research priorities, technological innovation, and societal benefits. In analysing the KBBE discourse, this paper draws on the sociology of technological expectations, which emphasises the performative, mobilising and self-fulfilling roles of such future-oriented visions. For example, the KBBE agenda shapes European research and innovation priorities in the bio-pharmaceutical sector. It frames socially relevant bio-knowledge in terms of pre-competitive research which can eventually facilitate new commercial products and patentable knowledge. Moreover, the agenda defines new institutional and policy frameworks necessary to realise societal benefits from these products and knowledge