Liquefaction Study Eastern Scheldt Foreshore

All available methods to obtain insight into the flow slide susceptibility have been applied on one location. This demonstrates, that the level of available knowledge is of influence on the quality of the advice. An overview of the methods and the results is given. The results are discussed. The conclusion is, that advanced study improves the understanding of uncertainties, and therefore gives a better assessment of risks. In this case, insight lead to the advice that no expensive measures were necessary, at least for part of the location

Erythrocyte deformability and aggregability in patients undergoing colon cancer surgery and effects of two infusions with omega-3 fatty acids

BACKGROUND: An adequate erythrocyte function is vital for tissue oxygenation and wound healing. The erythrocyte membrane phospholipid composition plays an important role in erythrocyte function and administration of omega-3 fatty acids may provide a means to improve it. OBJECTIVE: To investigate peri-operative erythrocyte function and effects of omega-3 fatty acids METHODS: Forty-four patients undergoing elective laparoscopic colon resection for non-metastasized cancer were randomized between intravenous omega-3 poly-unsaturated fatty acids (n-3 PUFAs) or placebo (saline). Peri-operative blood samples were analyzed with a Lorrca MaxSIS Ektacytometer and erythrocyte membrane phospholipids were determined with gas chromatography. RESULTS: Patient and operation characteristics were equal between groups. There was a significant increase in erythrocyte membrane eicosapentaenoic acid (EPA) but not docosahexaenoic acid (DHA) in the n-PUFA group. There were no significant differences in erythrocyte deformability but the aggregation index (AI) was significantly lower and the aggregation half time (T 1/2) was significantly higher in the n-3 PUFA group. CONCLUSION: This study confirms rapid changes in erythrocyte membrane phospholipid composition after administration of intravenous n-3 PUFAs. Erythrocyte deformability parameters were not affected but erythrocyte aggregability was decreased in the n-3 PUFA group. Further investigation is necessary to gain more insights in the effects of n-3 PUFA and the postoperative inflammatory response on erythrocyte function

PCR-based molecular marker for the Bdv2 Thinopyrum intermedium source of barley yellow dwarf virus resistance in wheat

Because of the importance of BYDV in wheat production worldwide, and given the difficulties of bioassaying for resistance, a molecular marker was developed for the resistance known as Bdv2 that originates on the long arm of chromosome 7Ai1 of Thinopyrum intermedium. This resistance was identified in a partial amphiploid line TAF46, a disomic addition line to wheat (L1), a telosomic addition line (7Ai1 L), and a series of recombinants and translocations. A RAPD (random amplified polymeric DNA) marker for the resistant germplasm was cloned and sequenced, and primers were designed against that sequence to produce a sequence characterised amplified region (SCAR) marker. A single PCR product is produced only with genotypes carrying the resistance from any of the available recombinants. The cloned sequence, recommended primers, and PCR protocols are described. The usefulness of the marker has been demonstrated for following Bdv2 in segregating wheat breeding germplasm, with the imminent release of a BYDV-resistant cultivar

Effects of perioperative intravenous omega-3 fatty acids in colon cancer patients:a randomized, double-blind, placebo-controlled clinical trial

Background: The postoperative inflammatory response contributes to tissue healing and recovery but overwhelming inflammation is associated with postoperative complications. n-3 (ω-3) PUFAs modulate inflammatory responses and may help to prevent a proinflammatory cascade. Objectives: We aimed to investigate the effects of perioperative intravenous n-3 PUFAs on inflammatory cytokines in colon cancer surgery. Methods: This study is a randomized, double-blind, placebo-controlled clinical trial. Forty-four patients undergoing elective colon resection for nonmetastasized cancer were randomly assigned to 2 intravenous n-3 PUFA or saline control infusions the night before and the morning after surgery. Blood was sampled at 6 perioperative time points for changes in cytokines in serum and in LPS-stimulated whole blood samples and leukocyte membrane fatty acid profiles. Results: Twenty-three patients received saline and 21 patients received n-3 PUFAs. Patient and operation characteristics were equal between groups, except for open resection (saline n = 5 compared with n-3 PUFA n = 0, P = 0.056). Ex-vivo IL-6 after LPS stimulation was significantly higher in the n-3 PUFA group at the first day after surgery (P = 0.014), but not different at the second day after surgery (P = 0.467). White blood cell count was higher in the n-3 PUFA group at the fourth day after surgery (P = 0.029). There were more patients with infectious complications in the n-3 PUFA group (8 compared with 3, P = 0.036). There were no overall differences in serum IL-6, IL-10, C-reactive protein, and length of stay. The administration of n-3 PUFAs resulted in rapid increases in leukocyte membrane n-3 PUFA content. Conclusions: In the n-3 PUFA group a clear relation with serum and LPS-stimulated cytokines was not found but, unexpectedly, more infectious complications occurred. Caution is thus required with the off-label use of a perioperative intravenous n-3 PUFA emulsion as a standalone infusion in the time sequence reported in the present study in colon resections with primary anastomosis. This trial was registered at clinicaltrials.gov as NCT02231203

Influence of daily 10-85 mu g vitamin D supplements during pregnancy and lactation on maternal vitamin D status and mature milk antirachitic activity

Pregnant and lactating women and breastfed infants are at risk of vitamin D deficiency. The supplemental vitamin D dose that optimises maternal vitamin D status and breast milk antirachitic activity (ARA) is unclear. Healthy pregnant women were randomised to 10 (n 10), 35 (n 11), 60 (n 11) and 85 (n 11) mu g vitamin D-3/d from 20 gestational weeks (GW) to 4 weeks postpartum (PP). The participants also received increasing dosages of fish oil supplements and a multivitamin. Treatment allocation was not blinded. Parent vitamin D and 25-hydroxyvitamin D (25(OH)D) were measured in maternal plasma at 20 GW, 36 GW and 4 weeks PP, and in milk at 4 weeks PP. Median 25(OH)D and parent vitamin D at 20 GW were 85 (range 25-131) nmol/l and 'not detectable (nd)' (range nd-40) nmol/l. Both increased, seemingly dose dependent, from 20 to 36 GW and decreased from 36 GW to 4 weeks PP. In all, 35 mu g vitamin D/d was needed to increase 25(OH)D to adequacy (80-249 nmol/l) in >97 center dot 5 % of participants at 36 GW, while >85 mu g/d was needed to reach this criterion at 4 weeks PP. The 25(OH)D increments from 20 to 36 GW and from 20 GW to 4 weeks PP diminished with supplemental dose and related inversely to 25(OH)D at 20 GW. Milk ARA related to vitamin D-3 dose, but the infant adequate intake of 513 IU/l was not reached. Vitamin D-3 dosages of 35 and >85 mu g/d were needed to reach adequate maternal vitamin D status at 36 GW and 4 weeks PP, respectively

Discussions and Replies Session 3

ABSTRAK   Efendi, Syaiful. 2016. Perbedaan Kompetensi Produktif antara Siswa Kelas Industri dengan Kelas Reguler Paket Keahlian Teknik Kendaraan Ringan di SMKN 10 Malang. Skripsi, Jurusan Teknik Mesin, Fakultas Teknik, Universitas Negeri Malang. Pembimbing: (I) Dr. Syarif Suhartadi, M.Pd., (II) Drs. H. Agus Sholah, M.Pd. Kata Kunci: kompetensi produktif, kelas industri, kelas reguler   Tujuan SMK adalah menyiapkan siswa untuk memasuki lapangan kerja dan  mengembangkan sikap profesionalis. Hal ini dapat diwujudkan melalui kerjasama internal dengan membuka kelas kerjasama atau kelas industri pada SMK. SMKN 10 Malang adalah salah satu sekolah yang menerapkan kelas kerjasama dengan pihak Honda di jurusan teknik kendaraan ringan. Kelas tersebut bernama kelas HTEC (Honda Technician Education Class) yang dirilis sejak tanggal 10 Desember 2014. Tujuan dengan adanya kelas HTEC ini mampu meningkatkan kompetensi produktif siswa pada kelas XII agar  mempunyai kompetensi yang baik. Penelitian ini bertujuan untuk mengetahui perbedaan kompetensi produktif antara siswa kelas industri dengan kelas reguler. Desain penelitian ini termasuk dalam desain eksperimen dengan post-test only control design. Variabel dalam penelitian ini terdiri dari variabel bebas dan variabel terikat. Variabel bebas dalam penelitian ini adalah pengelompokkan kelas yang terdiri dari kelas industri dan kelas reguler sedangkan kompetensi produktif merupakan variabel terikat. Subyek penelitian ini adalah siswa kelas XII Teknik Kendaraan Ringan pada kelas industri dan kelas reguler menggunakancluster sampling dan proportional sample sebagai teknik pengambilan sampel penelitian. Teknik analisis data yang digunakan adalah teknik uji t (Independent Sample t-Test). Rata-rata nilai post-test kompetensi produktif siswa kelas industri adalah 83.8 dan rata-rata nilai post-test kompetensi produktif siswa kelas reguler adalah 76.94. Hasil uji t diperoleh nilai sig. (2 tailed

Milk vitamin D in relation to the 'adequate intake' for 0-6-month-old infants:A study in lactating women with different cultural backgrounds, living at different latitudes

Breast-fed infants are susceptible to vitamin D deficiency rickets. The current vitamin D adequate intake' (AI) for 0-6-month-old infants is 10 mu g/d, corresponding with a human milk antirachitic activity (ARA) of 513 IU/l. We were particularly interested to see whether milk ARA of mothers with lifetime abundant sunlight exposure reaches the AI. We measured milk ARA of lactating mothers with different cultural backgrounds, living at different latitudes. Mature milk was derived from 181 lactating women in the Netherlands, Curacao, Vietnam, Malaysia and Tanzania. Milk ARA and plasma 25-hydroxyvitamin D (25(OH)D) were analysed by liquid-chromatography-MS/MS; milk fatty acids were analysed by GC-flame ionisation detector (FID). None of the mothers reached the milk vitamin D AI. Milk ARA (n; median; range) were as follows: Netherlands (n 9; 46 IU/l; 3-51), Curacao (n 10; 31 IU/l; 5-113), Vietnam: Halong Bay (n 20; 58 IU/l; 23-110), Phu Tho (n 22; 28 IU/l; 1-62), Tien Giang (n 20; 63 IU/l; 26-247), Ho-Chi-Minh-City (n 18; 49 IU/l; 24-116), Hanoi (n 21; 37 IU/l; 11-118), Malaysia-Kuala Lumpur (n 20; 14 IU/l; 1-46) and Tanzania-Ukerewe (n 21; 77 IU/l; 12-232) and Maasai (n 20; 88 IU/l; 43-189). We collected blood samples of these lactating women in Curacao, Vietnam and from Tanzania-Ukerewe, and found that 333 % had plasma 25(OH)D levels between 80 and 2499 nmol/l, 473 % between 50 and 799 nmol/l and 194 % between 25 and 499 nmol/l. Milk ARA correlated positively with maternal plasma 25(OH)D (range 27-132 nmol/l, r 040) and milk EPA+DHA (01-31 g%, r 020), and negatively with latitude (2 degrees S-53 degrees N, r -021). Milk ARA of mothers with lifetime abundant sunlight exposure is not even close to the vitamin D AI for 0-6-month-old infants. Our data may point at the importance of adequate fetal vitamin D stores

Technique of anterior colporrhaphy: a Dutch evaluation

Contains fulltext : 96395.pdf (publisher's version ) (Closed access)INTRODUCTION AND HYPOTHESIS: To evaluate the variation in techniques of anterior colporrhaphy among members of the Dutch Urogynecologic Society. METHODS: A questionnaire evaluating the technique of anterior colporrhaphy, preoperative and postoperative care, and use of the POP-Q score was sent out by e-mail. RESULTS: One hundred thirty-three completed questionnaires were received. The response rate was 65%. There are large variations in incisions, use of hydrodissection, method of plication, and excision of redundant vaginal epithelium. The urinary catheter was generally removed on day 2 after surgery and the vaginal pack on day 1. Less than half of the respondents used the POP-Q score routinely. CONCLUSIONS: Dutch gynecologists use a variety of surgical techniques to operate on a cystocele. This suggests that there is no widely accepted opinion on the best surgical approach. The lack of differentiation between central and lateral defects is striking and in contrast with the, mostly, American literature