Confusion matrices for each diagnostic decision (classifiers I–IV in panels A-D respectively).

<p>Numbers in each cell describe the total number of predictions.</p

Example confusion matrix for an m-class classification problem.

<p>C_i,j denotes the number of predictions in row i, column j. The sensitivity and predictive value measure the performance of each class. The accuracy and overall predictive value are constructed by averaging the sensitivity and predictive value over all classes. Note that the accuracy and overall predictive value are balanced in that they avoid potential bias arising from variable numbers of samples in each class.</p

Sensitivity (Sens) and predictive value (PV) for each region in the subcortical motor network for the four-class classifier contrasting PSP, IPD, HC and MSA (Classifier II).

<p>A: cerebellum; B: brainstem; C: caudate; D: putamen; E: pallidum; F: accumbens. Bars denote the chance levels determined by the proportion of samples in the training set. * = p < 0.01, # = p < 0.05 + = p < 0.1.</p

White matter maps showing regions of significant decreased fractional anisotropy and increased mean diffusivity in MSA patients when compared to healthy controls and PD (Bonferroni corrected alpha = 0.0167).

<p>Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p

Sensitivity (Sens) and predictive value (PV) for each class within each diagnostic classifier based on the subcortical motor network features (classifiers I–IV in panels A-D respectively).

<p>Bars denote the chance levels determined by the proportion of samples in the training set. * = p < 0.01, # = p < 0.05 + = p < 0.1.</p

White matter regions of fractional anisotropy changes between PSP, MSA, PD and HC.

<p>All results reported at p<0.05, TFCE and Bonferroni corrected (corrected alpha = 0.0167).</p><p>White matter regions of fractional anisotropy changes between PSP, MSA, PD and HC.</p

Demographic and clinical data of control subjects and patients with PD, MSA and PSP.

<p>* For patients taking levodopa drug treatment, scores given in the ‘on’ state.</p>†<p>From Parkinson's Plus Scale (Cerebellar Score, maximum 24; Occulomotor Score, maximum 21).</p><p>MSA  =  multiple systems atrophy; PSP  =  progressive supranuclear palsy; PD  =  Parkinson's disease; MSA-P  =  multiple system atrophy parkinsonian variant; MSA-C  =  multiple system atrophy cerebellar variant; H&Y  =  Hoehn and Yahr; ADL  =  activities of daily living; UPDRS III  =  Unified Parkinson Disease Rating Scale-part III.</p><p>Demographic and clinical data of control subjects and patients with PD, MSA and PSP.</p

White matter maps showing regions of significant correlation between mean diffusivity and measures of disease severity (Bonferroni corrected alpha = 0.0167).

<p>Top row coronal view, bottom row axial view. Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p

White matter regions of mean diffusivity changes between PSP, MSA, PD and HC.

<p>All results reported at p<0.05, TFCE and Bonferroni corrected (corrected alpha 0.0167).</p><p>White matter regions of mean diffusivity changes between PSP, MSA, PD and HC.</p

White matter maps showing regions of significant decreased fractional anisotropy and increased mean diffusivity in PSP patients when compared to healthy controls, PD and MSA (Bonferroni corrected alpha = 0.0167).

<p>Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p