5,044 research outputs found
Quantum Pair Creation of Soliton Domain Walls
A large body of experimental evidence suggests that the decay of the false
vacuum, accompanied by quantum pair creation of soliton domain walls, can occur
in a variety of condensed matter systems. Examples include nucleation of charge
soliton pairs in density waves [eg. J. H. Miller, Jr. et al., Phys. Rev. Lett.
84, 1555 (2000)] and flux soliton pairs in long Josephon junctions. Recently,
Dias and Lemos [J. Math. Phys. 42, 3292 (2001)] have argued that the mass
of the soliton should be interpreted as a line density and a surface density,
respectively, for (2+1)-D and (3+1)-D systems in the expression for the pair
production rate. As the transverse dimensions are increased and the total mass
(energy) becomes large, thermal activation becomes suppressed, so quantum
processes can dominate even at relatively high temperatures. This paper will
discuss both experimental evidence and theoretical arguments for the existence
of high-temperature collective quantum phenomena
Realistic Standard Model Fermion Mass Relations in Generalized Minimal Supergravity (GmSUGRA)
Grand Unified Theories (GUTs) usually predict wrong Standard Model (SM)
fermion mass relation m_e/m_{\mu} = m_d/m_s toward low energies. To solve this
problem, we consider the Generalized Minimal Supergravity (GmSUGRA) models,
which are GUTs with gravity mediated supersymmetry breaking and higher
dimensional operators. Introducing non-renormalizable terms in the super- and
K\"ahler potentials, we can obtain the correct SM fermion mass relations in the
SU(5) model with GUT Higgs fields in the {\bf 24} and {\bf 75} representations,
and in the SO(10) model. In the latter case the gauge symmetry is broken down
to SU(3)_C X SU(2)_L X SU(2)_R X U(1)_{B-L}, to flipped SU(5)X U(1)_X, or to
SU(3)_C X SU(2)_L X U(1)_1 X U(1)_2. Especially, for the first time we generate
the realistic SM fermion mass relation in GUTs by considering the
high-dimensional operators in the K\"ahler potential.Comment: JHEP style, 29 pages, no figure,references adde
Morphine-induced hallucinations - resolution with switching to oxycodone: a case report and review of the literature
Palliation of pain with morphine in cancer patients can be complicated by adverse effects. Tolerance to these effects such as nausea and drowsiness usually occurs within a few days allowing continuation of morphine therapy. However, some patients may develop intolerable adverse effects even after several months on morphine when the dose is increased. A case of morphine-induced hallucinations in a cancer patient who had been on a subcutaneous infusion of diamorphine for several months is discussed. A switch to oxycodone resolved his hallucinations and gave him a new lease of life. The theories behind and evidence for opioid-switching is discussed along with strategies for dealing with intolerable opioid-induced adverse effects
Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing Gn protects mice against rift valley fever virus
Background: Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas. In addition, it is a potential biowarfare agent. Methodology/Principal Findings: We developed two potential vaccines, DNA plasmids and alphavirus replicons, expressing the Gn glycoprotein of RVFV alone or fused to three copies of complement protein, C3d. Each vaccine was administered to mice in an all DNA, all replicon, or a DNA prime/replicon boost strategy and both the humoral and cellular responses were assessed. DNA plasmids expressing Gn-C3d and alphavirus replicons expressing Gn elicited high titer neutralizing antibodies that were similar to titers elicited by the live-attenuated MP12 virus. Mice vaccinated with an inactivated form of MP12 did elicit high titer antibodies, but these antibodies were unable to neutralize RVFV infection. However, only vaccine strategies incorporating alphavirus replicons elicited cellular responses to Gn. Both vaccines strategies completely prevented weight loss and morbidity and protected against lethal RVFV challenge. Passive transfer of antisera from vaccinated mice into naïve mice showed that both DNA plasmids expressing Gn-C3d and alphavirus replicons expressing Gn elicited antibodies that protected mice as well as sera from mice immunized with MP12. Conclusion/Significance: These results show that both DNA plasmids expressing Gn-C3d and alphavirus replicons expressing Gn administered alone or in a DNA prime/replicon boost strategy are effective RVFV vaccines. These vaccine strategies provide safer alternatives to using live-attenuated RVFV vaccines for human use. © 2010 Bhardwaj et al
J D Bernal: philosophy, politics and the science of science
This paper is an examination of the philosophical and political legacy of John Desmond Bernal. It addresses the evidence of an emerging consensus on Bernal based on the recent biography of Bernal by Andrew Brown and the reviews it has received. It takes issue with this view of Bernal, which tends to be admiring of his scientific contribution, bemused by his sexuality, condescending to his philosophy and hostile to his politics. This article is a critical defence of his philosophical and political position
LHC Searches for Non-Chiral Weakly Charged Multiplets
Because the TeV-scale to be probed at the Large Hadron Collider should shed
light on the naturalness, hierarchy, and dark matter problems, most searches to
date have focused on new physics signatures motivated by possible solutions to
these puzzles. In this paper, we consider some candidates for new states that
although not well-motivated from this standpoint are obvious possibilities that
current search strategies would miss. In particular we consider vector
representations of fermions in multiplets of with a lightest neutral
state. Standard search strategies would fail to find such particles because of
the expected small one-loop-level splitting between charged and neutral states.Comment: 16 pages, 9 figure
J D Bernal: philosophy, politics and the science of science
This paper is an examination of the philosophical and political legacy of John Desmond Bernal. It addresses the evidence of an emerging consensus on Bernal based on the recent biography of Bernal by Andrew Brown and the reviews it has received. It takes issue with this view of Bernal, which tends to be admiring of his scientific contribution, bemused by his sexuality, condescending to his philosophy and hostile to his politics. This article is a critical defence of his philosophical and political position
Cosmographic Hubble fits to the supernova data
The Hubble relation between distance and redshift is a purely cosmographic
relation that depends only on the symmetries of a FLRW spacetime, but does not
intrinsically make any dynamical assumptions. This suggests that it should be
possible to estimate the parameters defining the Hubble relation without making
any dynamical assumptions. To test this idea, we perform a number of
inter-related cosmographic fits to the legacy05 and gold06 supernova datasets.
Based on this supernova data, the "preponderance of evidence" certainly
suggests an accelerating universe. However we would argue that (unless one uses
additional dynamical and observational information) this conclusion is not
currently supported "beyond reasonable doubt". As part of the analysis we
develop two particularly transparent graphical representations of the
redshift-distance relation -- representations in which acceleration versus
deceleration reduces to the question of whether the relevant graph slopes up or
down. Turning to the details of the cosmographic fits, three issues in
particular concern us: First, the fitted value for the deceleration parameter
changes significantly depending on whether one performs a chi^2 fit to the
luminosity distance, proper motion distance or other suitable distance
surrogate. Second, the fitted value for the deceleration parameter changes
significantly depending on whether one uses the traditional redshift variable
z, or what we shall argue is on theoretical grounds an improved
parameterization y=z/(1+z). Third, the published estimates for systematic
uncertainties are sufficiently large that they certainly impact on, and to a
large extent undermine, the usual purely statistical tests of significance. We
conclude that the supernova data should be treated with some caution.Comment: 28 pages, 4 figure
A Profile Likelihood Analysis of the Constrained MSSM with Genetic Algorithms
The Constrained Minimal Supersymmetric Standard Model (CMSSM) is one of the
simplest and most widely-studied supersymmetric extensions to the standard
model of particle physics. Nevertheless, current data do not sufficiently
constrain the model parameters in a way completely independent of priors,
statistical measures and scanning techniques. We present a new technique for
scanning supersymmetric parameter spaces, optimised for frequentist profile
likelihood analyses and based on Genetic Algorithms. We apply this technique to
the CMSSM, taking into account existing collider and cosmological data in our
global fit. We compare our method to the MultiNest algorithm, an efficient
Bayesian technique, paying particular attention to the best-fit points and
implications for particle masses at the LHC and dark matter searches. Our
global best-fit point lies in the focus point region. We find many
high-likelihood points in both the stau co-annihilation and focus point
regions, including a previously neglected section of the co-annihilation region
at large m_0. We show that there are many high-likelihood points in the CMSSM
parameter space commonly missed by existing scanning techniques, especially at
high masses. This has a significant influence on the derived confidence regions
for parameters and observables, and can dramatically change the entire
statistical inference of such scans.Comment: 47 pages, 8 figures; Fig. 8, Table 7 and more discussions added to
Sec. 3.4.2 in response to referee's comments; accepted for publication in
JHE
The generalised NMSSM at one loop: fine tuning and phenomenology
We determine the degree of fine tuning needed in a generalised version of the
NMSSM that follows from an underlying Z4 or Z8 R symmetry. We find that it is
significantly less than is found in the MSSM or NMSSM and extends the range of
Higgs mass that have acceptable fine tuning up to Higgs masses of mh ~ 130 GeV.
For universal boundary conditions analogous to the CMSSM the phenomenology is
rather MSSM like with the singlet states typically rather heavy. For more
general boundary conditions the singlet states can be light, leading to
interesting signatures at the LHC and direct detection experiments.Comment: 20 pages, 9 figures, matches published versio
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