Thrombotic variables and risk of idiopathic venous thromboembolism in women aged 45-64 years - Relationships to hormone replacement therapy

Hormone replacement therapy (HRT) has been shown to increase the relative risk of idiopathic venous thromboembolism (VTE) about threefold in several observational studies and one randomised controlled trial. Whether or not this relative risk is higher in women with underlying thrombophilia phenotypes, such as activated protein C (APC) resistance, is unknown. We therefore restudied the participants in a case-control study of the relationship between the use of HRT and the occurrence of idiopathic VTE in women aged 45-64 years. After protocol exclusions, 66 of the cases in the original study and 163 of the controls were studied. Twenty haematological variables relevant to risk of VTE were analysed, including thrombotic states defined from the literature. The relative risk of VTE showed significant associations with APC resistance (OR 4.06; 95% CI 1.62, 10.21); low antithrombin (3.33; 1.15, 9.65) or protein C (2.93; 1.06, 8.14); and high coagulation factor IX (2.34: 1.26, 1.35), or fibrin D-dimer (3.84; 1.99, 7.32). HRT use increased the risk of VTE in women without any of these thrombotic static; (OR 4.09; 95% CI 1.26, 13.30). A similar effect of HRT use on the relative risk of VTE was also found in women with prothrombotic states. Thus for example, the combination of HRT use and APC resistance increased the risk of VTE about 13-fold compared with women of similar age without either APC resistance or HRT use (OR 13.27; 95%, CI 4.30, 40.97). We conclude that the combination of HRT use and thrombophilias (especially if multiple) increases the relative risk of VTE substantially; hence women known to have thrombophilias (especially if multiple) should be counselled about this increased risk prior to prescription of HRT. However. HRT increases the risk of VTE about fourfold even in women without any thrombotic abnormalities: possible causes are discussed

Epitaxial Thin Films of the Giant-Dielectric-Constant Material CaCu_3Ti_4O_{12} Grown by Pulsed-laser Deposition

Pulsed-laser deposition has been used to grow epitaxial thin films of the giant-dielectric-constant material CaCu_3Ti_4O_{12} on LaAlO_3 and SrTiO_3 substrates with or without various conducting buffer layers. The latter include YBa_2Cu_3O_7, La_{1.85}Sr_{0.15}CuO_{4+\delta} and LaNiO_3. Above 100K - 150K the thin films have a temperature independent dielectric constant as do single crystals. The value of the dielectric constant is of the order of 1500 over a wide temperature region, potentially making it a good candidate for many applications. The frequency dependence of its dielectric properties below 100K - 150K indicates an activated relaxation process.Comment: 11 pages, 4 figure

Forward acoustic performance of a shock-swallowing high-tip-speed fan (QF-13)

Forward noise and overall aerodynamic performance data are presented for a high-tip-speed fan having rotor blade airfoils designed to alter the conventional leading-edge bow shocks to weak, oblique shocks which are swallowed within the interblade channels. It was anticipated that the swallowed shocks would minimize the generation of multiple-pure-tone noise. In the speed range where the shocks presumably were swallowed, the multiple-tone noise was lowered only about 3 decibels. Comparison with several high-speed fans on a thrust-corrected basis indicates that the present fan was the quietest in total forward noise at low speeds but offered no advantage at high speeds

Acoustic evaluation of a novel swept-rotor fan

Inlet noise and aerodynamic performance are presented for a high tip speed fan designed with rotor blade leading edge sweep that gives a subsonic component of inlet Mach number normal to the edge at all radii. The intent of the design was to minimize the generation of rotor leading edge shock waves thereby minimizing multiple pure tone noise. Sound power level and spectral comparisons are made with several high-speed fans of conventional design. Results show multiple pure tone noise at levels below those of some of the other fans and this noise was initiated at a higher tip speed. Aerodynamic performance of the fan did not meet design goals for this first build which applied conventional design procedures to the swept fan geometry

Study of the volume and spin collapse in orthoferrite LuFeO_3 using LDA+U

Rare earth (R) orthoferrites RFeO_3 exhibit large volume transitions associated with a spin collapse. We present here ab initio calculations on LuFeO_3. We show that taking into account the strong correlation among the Fe-3d electrons is necessary. Indeed, with the LDA+U method in the Projector Augmented Wave (PAW), we are able to describe the isostructural phase transition at 50 GPa, as well as a volume discontinuity of 6.0% at the transition and the considerable reduction of the magnetic moment on the Fe ions. We further investigate the effect of the variation of U and J and find a linear dependence of the transition pressure on these parameters. We give an interpretation for the non-intuitive effect of J. This emphasizes the need for a correct determination of these parameters especially when the LDA+U is applied to systems (e.g in geophysical investigations) where the transition pressure is a priori unknown

Fan noise reduction achieved by removing tip flow irregularities behind the rotor - forward arc test configurations

The noise source caused by the interaction of the rotor tip flow irregularities (vortices and velocity defects) with the downstream stator vanes was studied. Fan flow was removed behind a 0.508 meter (20 in.) diameter model turbofan through an outer wall slot between the rotor and stator. Noise measurements were made with far-field microphones positioned in an arc about the fan inlet and with a pressure transducer in the duct behind the stator. Little tone noise reduction was observed in the forward arc during flow removal; possibly because the rotor-stator interaction noise did not propagate upstream through the rotor. Noise reductions were maded in the duct behind the stator and the largest decrease occurred with the first increment of flow removal. This result indicates that the rotor tip flow irregularity-stator interaction is as important a noise producing mechanism as the normally considered rotor wake-stator interaction

Reduction of fan noise in an anechoic chamber by reducing chamber wall induced inlet flow disturbances

The difference between the flight and ground static noise of turbofan engines presents a significant problem in engine noise testing. The additional noise for static testing has been attributed to inlet flow disturbances or turbulence interacting with the fan rotor. In an attempt to determine a possible source of inflow disturbances entering fans tested in the Lewis Research Center anechoic chamber, the inflow field was studied using potential flow analysis. These potential flow calculations indicated that there was substantial flow over the wall directly behind the fan inlet that could produce significant inflow disturbances. Fan noise tests were run with various extensions added to the fan inlet to move the inlet away from this backwall and thereby reduce the inlet flow disturbances. Significant noise reductions were observed with increased inlet length. Over 5 db reduction of the blade passage tone sound power level was observed between the shortest and longest inlets at 90% fan speed and the first overtone was reduced 9 db. High frequency broadband noise was also reduced

Octahedral Tilt Instability of ReO_3-type Crystals

The octahedron tilt transitions of ABX_3 perovskite-structure materials lead to an anti-polar (or antiferroelectric) arrangement of dipoles, with the low temperature structure having six sublattices polarized along various crystallographic directions. It is shown that an important mechanism driving the transition is long range dipole-dipole forces acting on both displacive and induced parts of the anion dipole. This acts in concert with short range repulsion, allowing a gain of electrostatic (Madelung) energy, both dipole-dipole and charge-charge, because the unit cell shrinks when the hard ionic spheres of the rigid octahedron tilt out of linear alignment.Comment: 4 page with 3 figures included; new version updates references and clarifies the argument

Effectiveness of an inlet flow turbulence control device to simulate flight noise fan in an anechoic chamber

A hemispherical inlet flow control device was tested on a 50.8 cm. (20-inch) diameter fan stage in the NASA-Lewis anechoic chamber. The control device used honeycomb and wire mesh to reduce turbulence intensities entering the fan. Far field acoustic power level results show about a 5 db reduction in blade passing tone and about 10 dB reduction in multiple pure tone sound power at 90% design fan speed with the inlet device in place. Hot film cross probes were inserted in the inlet to obtain data for two components of the turbulence at 65 and 90% design fan speed. Without the flow control device, the axial intensities were below 1.0%, while the circumferential intensities were almost twice this value. The inflow control device significantly reduced the circumferential turbulence intensities and also reduced the axial length scale

Looking for Design in Materials Design

Despite great advances in computation, materials design is still science fiction. The construction of structure-property relations on the quantum scale will turn computational empiricism into true design.Comment: 3 pages, 1 figur