Quelle est la mobilité quotidienne des personnes dans les agglomérations ? Approche de la question et propositions d'indicateurs

La nécessité de mieux comprendre les liens entre urbanisme et déplacements est au cœur des préoccupations actuelles en matière de planification et d’aménagement du territoire. Le présent rapport a pour objectif de développer la connaissance de la structure des déplacements, de leur évolution récente et de leurs déterminants. Au-delà, il vise à mieux appréhender les besoins de la population en matière de mobilité quotidienne, en fonction notamment des localisations des populations, des entreprises et des équipements sur le territoire des agglomérations, de l’évolution des modes de vie… L’observation de la mobilité quotidienne devient de ce fait l’une des clés de la compréhension du fonctionnement territorial. Elle traduit en effet la structuration de l’espace urbain, ainsi que la recomposition de l’occupation du sol. L’analyse de cette mobilité trouve donc pleinement sa place dans le programme dédié à l’observation des mutations urbaines. Dans ce dossier, elle a été segmentée en deux parties : d’une part, la qualification globale de la mobilité quotidienne, d’autre part, sa relation avec l’organisation territoriale. Cet ouvrage propose donc une approche pour appréhender la mobilité quotidienne des personnes (motifs, modes, pôles attractifs…) et présente de façon détaillée les indicateurs qu’il est possible d’utiliser pour cela. Chacun d’eux est documenté de façon très précise : liens entretenus avec la question posée, modes de calcul, sources utilisables, illustrations issues de tests réalisés sur cinq sites expérimentaux, extensions possibles ainsi que limites et précautions à prendre en compte pour leur utilisation. Les professionnels de l’observation y trouveront tous les éléments leur permettant de mettre en œuvre les indicateurs proposés sur leur territoire pour procéder à leurs propres analyses, dès lors qu’ils possèdent localement les données nécessaires

How Gibbs distributions may naturally arise from synaptic adaptation mechanisms. A model-based argumentation

This paper addresses two questions in the context of neuronal networks dynamics, using methods from dynamical systems theory and statistical physics: (i) How to characterize the statistical properties of sequences of action potentials ("spike trains") produced by neuronal networks ? and; (ii) what are the effects of synaptic plasticity on these statistics ? We introduce a framework in which spike trains are associated to a coding of membrane potential trajectories, and actually, constitute a symbolic coding in important explicit examples (the so-called gIF models). On this basis, we use the thermodynamic formalism from ergodic theory to show how Gibbs distributions are natural probability measures to describe the statistics of spike trains, given the empirical averages of prescribed quantities. As a second result, we show that Gibbs distributions naturally arise when considering "slow" synaptic plasticity rules where the characteristic time for synapse adaptation is quite longer than the characteristic time for neurons dynamics.Comment: 39 pages, 3 figure

A discrete time neural network model with spiking neurons II. Dynamics with noise

We provide rigorous and exact results characterizing the statistics of spike trains in a network of leaky integrate and fire neurons, where time is discrete and where neurons are submitted to noise, without restriction on the synaptic weights. We show the existence and uniqueness of an invariant measure of Gibbs type and discuss its properties. We also discuss Markovian approximations and relate them to the approaches currently used in computational neuroscience to analyse experimental spike trains statistics.Comment: 43 pages - revised version - to appear il Journal of Mathematical Biolog

Prosthetic overhang is the most effective way to prevent scapular conflict in a reverse total shoulder prosthesis

Methods An average and a "worst case scenario" shape in A-P view in a 2-D computer model of a scapula was created, using data from 200 "normal" scapulae, so that the position of the glenoid and humeral component could be changed as well as design features such as depth of the polyethylene insert, the size of glenosphere, the position of the center of rotation, and downward glenoid inclination. The model calculated the maximum adduction (notch angle) in the scapular plane when the cup of the humeral component was in conflict with the scapula. Results A change in humeral neck shaft inclination from 155 degrees to 145 degrees gave a 10 degrees gain in notch angle. A change in cup depth from 8 mm to 5 mm gave a gain of 12 degrees. With no inferior prosthetic overhang, a lateralization of the center of rotation from 0 mm to 5 mm gained 16 degrees. With an inferior overhang of only 1 mm, no effect of lateralizing the center of rotation was noted. Downward glenoid inclination of 0 boolean OR to 10 boolean OR gained 10 degrees. A change in glenosphere radius from 18 mm to 21 mm gained 31 degrees due to the inferior overhang created by the increase in glenosphere. A prosthetic overhang to the bone from 0 mm to 5 mm gained 39 degrees. Interpretation Of all 6 solutions tested, the prosthetic overhang created the biggest gain in notch angle and this should be considered when designing the reverse arthroplasty and defining optimal surgical technique

Mutations in the Polycomb Group Gene polyhomeotic Lead to Epithelial Instability in both the Ovary and Wing Imaginal Disc in Drosophila

Most human cancers originate from epithelial tissues and cell polarity and adhesion defects can lead to metastasis. The Polycomb-Group of chromatin factors were first characterized in Drosophila as repressors of homeotic genes during development, while studies in mammals indicate a conserved role in body plan organization, as well as an implication in other processes such as stem cell maintenance, cell proliferation, and tumorigenesis. We have analyzed the function of the Drosophila Polycomb-Group gene polyhomeotic in epithelial cells of two different organs, the ovary and the wing imaginal disc.Clonal analysis of loss and gain of function of polyhomeotic resulted in segregation between mutant and wild-type cells in both the follicular and wing imaginal disc epithelia, without excessive cell proliferation. Both basal and apical expulsion of mutant cells was observed, the former characterized by specific reorganization of cell adhesion and polarity proteins, the latter by complete cytoplasmic diffusion of these proteins. Among several candidate target genes tested, only the homeotic gene Abdominal-B was a target of PH in both ovarian and wing disc cells. Although overexpression of Abdominal-B was sufficient to cause cell segregation in the wing disc, epistatic analysis indicated that the presence of Abdominal-B is not necessary for expulsion of polyhomeotic mutant epithelial cells suggesting that additional polyhomeotic targets are implicated in this phenomenon.Our results indicate that polyhomeotic mutations have a direct effect on epithelial integrity that can be uncoupled from overproliferation. We show that cells in an epithelium expressing different levels of polyhomeotic sort out indicating differential adhesive properties between the cell populations. Interestingly, we found distinct modalities between apical and basal expulsion of ph mutant cells and further studies of this phenomenon should allow parallels to be made with the modified adhesive and polarity properties of different types of epithelial tumors