Load Induced Blindness

Although the perceptual load theory of attention has stimulated a great deal of research, evidence for the role of perceptual load in determining perception has typically relied on indirect measures that infer perception from distractor effects on reaction times or neural activity (see N. Lavie, 2005d`) was consistently reduced with high, compared to low, perceptual load but was unaffected by the level of working memory load. Because alternative accounts in terms of expectation, memory, response bias, and goal-neglect due to the more strenuous high load task were ruled out, these experiments clearly demonstrate that high perceptual load determines conscious perception, impairing the ability to merely detect the presence of a stimulus—a phenomenon of load induced blindness

Attentional demand estimation with attentive driving models

The task of driving can sometimes require the processing of large amounts of visual information; such situations can overload the perceptual systems of human drivers leading to ‘inattentional blindness’, where potentially critical visual information is overlooked. This phenomenon of ‘looking but failing to see’ is the third largest contributor to traffic accidents in the UK. In this work we develop a method to identify these particularly demanding driving scenes using an end-to-end driving architecture, imbued with a spatial attention mechanism and trained to mimic ground-truth driving controls from video input. At test time, the network’s attention distribution is segmented to identify relevant items in the driving scene which are used to estimate the attentional demand on the driver according to an established model in cognitive neuroscience. Without collecting any ground-truth attentional demand data - instead using readily available odometry data in a novel way - our approach is shown to outperform several baselines on a new dataset of 1200 driving scenes labelled for attentional demand in driving

Visual perceptual load induces inattentional deafness

In this article, we establish a new phenomenon of “inattentional deafness” and highlight the level of load on visual attention as a critical determinant of this phenomenon. In three experiments, we modified an inattentional blindness paradigm to assess inattentional deafness. Participants made either a low- or high-load visual discrimination concerning a cross shape (respectively, a discrimination of line color or of line length with a subtle length difference). A brief pure tone was presented simultaneously with the visual task display on a final trial. Failures to notice the presence of this tone (i.e., inattentional deafness) reached a rate of 79% in the high-visual-load condition, significantly more than in the low-load condition. These findings establish the phenomenon of inattentional deafness under visual load, thereby extending the load theory of attention (e.g., Lavie, Journal of Experimental Psychology. Human Perception and Performance, 25, 596–616, 1995) to address the cross-modal effects of visual perceptual load

Niacin-induced clotting factor synthesis deficiency with coagulopathy

Although coagulopathy is a well-known complication of severe niacin- induced hepatotoxic reaction, it is not found in patients with minimal aminotransferase level elevations. Three patients with significant clotting factor synthesis deficiency and coagulopathy (prothrombin times, >1.5 times control) from sustained-release niacin had only mild aminotransferase level elevations (1.5 to 2.0 times normal). In each case, protein deficiency, coagulopathy, and aminotransferase level elevation resolved promptly after withdrawal of niacin therapy. In one case, this syndrome recurred after rechallenge with sustained-release niacin, whereas the coagulopathy did not recur in a second patient rechallenged with crystalline niacin. Deficiency in protein synthesis, including coagulation factors, and coagulopathy are unrecognized complications of sustained-release niacin therapy. These cases indicate the need to measure prothrombin times routinely in patients who develop even mild aminotransferase level elevation while receiving sustained- release niacin therapy. These data are important in light of the increasing use of sustained-release niacin in the treatment of patients with lipid disorders

High-energy environment of super-Earth 55 Cnc e I: Far-UV chromospheric variability as a possible tracer of planet-induced coronal rain

The irradiation of close-in planets by their star influences their evolution and might be responsible for a population of ultra-short period planets eroded to their bare core. In orbit around a bright, nearby G-type star, the super-Earth 55 Cnc e offers the possibility to address these issues through UV transit observations. We used the Hubble Space Telescope to observe the transit in the FUV over 3 epochs in Apr. 2016, Jan. 2017, and Feb. 2017. These observations reveal significant short- and long-term variability in 55 Cnc chromospheric emission lines. In the last 2 epochs, we detected a larger flux in the C III, Si III, and Si IV lines after the planet passed the approaching quadrature, followed by a flux decrease in the Si IV doublet. In the second epoch these variations are contemporaneous with flux decreases in the Si II and C II doublet. All epochs show flux decreases in the N V doublet as well, albeit at different orbital phases. These flux decreases are consistent with absorption from optically thin clouds of gas, are mostly localized at low and redshifted radial velocities in the star rest frame, and occur preferentially before and during the transit. These 3 points make it unlikely that the variations are purely stellar, yet we show that the occulting material is also unlikely to originate from the planet. We tentatively propose that the motion of 55 Cnc e at the fringes of the stellar corona leads to the formation of a cool coronal rain. The inhomogeneity and temporal evolution of the stellar corona would be responsible for the differences between the visits. Additional variations are detected in the C II doublet in the first epoch and in the O I triplet in all epochs with a different behavior that points toward intrinsic stellar variability. Further observations at FUV wavelengths are required to disentangle between star-planet interactions and the activity of the starComment: 22 pages, 20 figures, accepted for publication in A&

Co-Management of COVID-19 and heart failure during the COVID-19 pandemic. lessons learned

The COVID pandemic has brought many new challenges worldwide, which has impacted on patients with chronic conditions. There is an increasing evidence base suggesting an interaction between chronic heart failure (HF) and COVID-19, and in turn the prognostic impact of co-existence of the two conditions. Patients with existing HF appear more prone to develop severe complications on contracting COVID-19, but the exact prevalence in patients with mild symptoms of COVID-19 not requiring hospital admission is poorly investigated. In addition, hospitalization rates for acute HF over the pandemic period appear reduced compared to previous periods. Several key issues remain rather unaddressed and, importantly, a specific algorithm focused on diagnostic differentiation between HF and acute respiratory distress syndrome, a severe complication of COVID-19, is still lacking. Furthermore, recent data suggests potential interaction existing between HF treatment and some anti-viral anti-inflammatory drugs prescribed during the infection, raising some doubts about a universal treatment strategy for all patients with COVID-19. With this manuscript, we aim to review the current literature in this field in light of growing understanding of COVID-19 in the setting of the HF population, its associated morbidity and mortality burden, and the impact on healthcare systems. We hope that this may stimulate a discussion to guarantee a better, more tailored delivery of care for patients with HF in the setting of concomitant COVID-19 infection

The long egress of GJ~436b's giant exosphere

The M dwarf GJ 436 hosts a transiting warm Neptune known to experience atmospheric escape. Previous observations revealed the presence of a giant hydrogen exosphere transiting the star for more than 5 h, and absorbing up to 56% of the flux in the blue wing of the stellar Lyman-{\alpha} line of neutral hydrogen (H i Ly{\alpha}). The unexpected size of this comet-like exosphere prevented observing the full transit of its tail. In this Letter, we present new Ly{\alpha} observations of GJ 436 obtained with the Space Telescope Imaging Spectrograph (STIS) instrument onboard the Hubble Space Telescope. The stability of the Ly{\alpha} line over six years allowed us to combine these new observations with archival data sets, substantially expanding the coverage of the exospheric transit. Hydrogen atoms in the tail of the exospheric cloud keep occulting the star for 10-25 h after the transit of the planet, remarkably confirming a previous prediction based on 3D numerical simulations with the EVaporating Exoplanet code (EVE). This result strengthens the interpretation that the exosphere of GJ 436b is shaped by both radiative braking and charge exchanges with the stellar wind. We further report flux decreases of 15 +/- 2% and 47 +/- 10% in the red wing of the Ly{\alpha} line and in the line of ionised silicon (Si iii). Despite some temporal variability possibly linked with stellar activity, these two signals occur during the exospheric transit and could be of planetary origin. Follow-up observations will be required to assess the possibility that the redshifted Ly{\alpha} and Si iii absorption signatures arise from interactions between the exospheric flow and the magnetic field of the star.Comment: 10 pages, 7 figures, published in A&