6 research outputs found
Common variants at 10 genomic loci influence hemoglobin Aâ(C) levels via glycemic and nonglycemic pathways.
- Author
- A. Bonnefond (7609472)
- A. Cao (6643043)
- A. Döring (7609562)
- A. F. Stewart (7608944)
- A. F. Wright (7609490)
- A. Goel (7602413)
- A. Greinacher (7609298)
- A. Hall (7131740)
- A. Hamsten (7602395)
- A. J. Swift (7609451)
- A. Jula (7609328)
- A. Kong (6907133)
- A. Köttgen (7609343)
- A. MĂ€larstig (7609382)
- A. Silveira (7609433)
- A. Teumer (7609454)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- B. Balkau (7609544)
- B. Böhm (5867516)
- B. F. Voight (7605833)
- B. KĂŒhnel (7609352)
- B. Wright (7609538)
- C. Franklin (7609283)
- C. Gieger (7609259)
- C. Hayward (7609304)
- C. Herder (3531713)
- C. Langenberg (7608872)
- C. Lecoeur (7609361)
- C. Meisinger (3995486)
- C. O'Donnell (7609556)
- C. S. Fox (7609280)
- C. W. Knouff (7609337)
- C. Willenborg (7605947)
- C. Zabena (7609499)
- D. Altshuler (7606010)
- D. Arking (7609541)
- D. Barnes (775647)
- D. Hadley (7609301)
- D. I. Boomsma (1812745)
- D. J. Rader (7605215)
- D. M. Nathan (7609418)
- D. M. Waterworth (7609469)
- D. P. Strachan (3809152)
- D. Radke (7609262)
- D. Schlessinger (7609430)
- D. Siscovick (7605995)
- E. Boerwinkle (7609103)
- E. J. de Geus (7609535)
- E. Porcu (3354512)
- E. Selvin (7609373)
- E. Stolerman (7609268)
- E. Wheeler (4607599)
- F. Payne (7609349)
- F. S. Collins (7609505)
- G. Abecasis (7609514)
- G. H. Williams (7609481)
- G. Homuth (7609310)
- G. Rocheleau (7609364)
- G. Thorleifsson (7606022)
- G. Usala (7609460)
- G. Willemsen (7609478)
- H. Campbell (7609436)
- H. E. Wichmann (7608932)
- H. Grallert (4107469)
- H. H. Hakonarson (7609502)
- H. Schunkert (7603670)
- H. Völzke (6643736)
- H. Wallaschofski (7609466)
- H. Watkins (7602419)
- I. Barroso (7609532)
- I. Prokopenko (7608875)
- I. Rudan (7609409)
- I. Surakka (7606076)
- J. B. Meigs (7608965)
- J. C. Florez (7608869)
- J. Chambers (3846385)
- J. Coresh (7609520)
- J. Dupuis (7608866)
- J. Erdmann (7603664)
- J. F. Peden (7602416)
- J. F. Wilson (7605311)
- J. Graessler (7609292)
- J. H. Zhao (1395031)
- J. J. Hottenga (7609313)
- J. Kooner (7609340)
- J. Kuusisto (7609355)
- J. Luan (7609367)
- J. M. Devaney (7609289)
- J. M. Egan (7608917)
- J. S. Pankow (7609316)
- J. Winkelmann (7609487)
- K Stefansson (7609439)
- K. Krohn (2494780)
- K. L. Mohlke (7605866)
- K. Oexle (7609274)
- K. Song (7608860)
- K. T. Khaw (7609508)
- L. Ferrucci (7608902)
- L. Groop (7609070)
- L. L. Bonnycastle (7609496)
- L. Peltonen (7606004)
- M. A. Morken (7609412)
- M. Boehnke (7605344)
- M. D. Fleming (7609511)
- M. Dei (7609559)
- M. G. Franzosi (7602410)
- M. I. McCarthy (7609121)
- M. Kleber (7609331)
- M. Laakso (7609358)
- M. Lathrop (7602425)
- M. Li (621494)
- M. M. Heeney (7609427)
- M. Mangino (7609385)
- M. Nauck (6643733)
- M. P. Reilly (7605332)
- M. Perola (7605860)
- M. Roden (7609388)
- M. S. Burnett-Miller (7609553)
- M. S. Sandhu (7609271)
- M. Serrano-RĂos (7609400)
- M. Stumvoll (7609448)
- M. T. MartĂnez-Larrad (7609391)
- M. Uda (7609529)
- N. Bouatia-Naji (7609265)
- N. Forouhi (7609277)
- N. J. Samani (7591811)
- N. J. Wareham (7608962)
- N. L. Pedersen (7609403)
- N. Narisu (7609415)
- N. Olla (7609295)
- N. Soranzo (7608857)
- O. Melander (7602683)
- O. Polasek (7609424)
- P. Deloukas (7603691)
- P. Froguel (7609517)
- P. K. Magnusson (7609379)
- P. Kovacs (7609346)
- P. Schwarz (7609334)
- P. Shrader (7609421)
- R. Clark (7609484)
- R. Elosua (7605998)
- R. Hunter-Merrill (7609319)
- R. J. Loos (7608845)
- R. McPherson (7605974)
- R. MĂ€gi (7609376)
- R. Roberts (2820928)
- R. Saxena (7608878)
- R. Sladek (7608881)
- R. Strawbridge (7609445)
- S. Bumpstead (7609550)
- S. E. Epstein (7606061)
- S. Gallina (7609286)
- S. H. Wild (7609475)
- S. Heath (7609307)
- S. Kathiresan (7606013)
- S. L. Ricketts (7608920)
- S. R. Bornstein (7609526)
- S. Ripatti (7606073)
- S. Sanna (7609256)
- T. D. Spector (7608968)
- T. Illig (7609322)
- T. Meitinger (14191)
- T. Tanaka (3979952)
- U. Seedorf (7602437)
- U. Thorsteinsdottir (7606031)
- V. E. Mooser (7609406)
- V. Lyssenko (7609370)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- V. Vitart (7609463)
- W. H. Kao (7609523)
- W. L. McArdle (7609397)
- W. MĂ€rz (7609394)
- W. Rathmann (3531737)
- WTCCC (7609493)
- Y. Böttcher (7609547)
- Publication venue
- Publication date
- 01/12/2010
- Field of study
Glycated hemoglobin (HbAâ(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbAâ(c). We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbAâ(c) levels
Rare and low-frequency coding variants alter human adult heigh
- Author
- A. A. Burt (7725410)
- A. D. Morris (7611470)
- A. E. Justice (7652732)
- A. E. Locke (7698281)
- A. G. Uitterlinden (7611476)
- A. Giri (7725485)
- A. I. den Hollander (7725449)
- A. J. Cox (7725431)
- A. K. Manning (7652627)
- A. L. Mazul (7725590)
- A. Linneberg (3444095)
- A. Lophatananon (4901776)
- A. M. Dunning (7658231)
- A. Mahajan (7603748)
- A. Metspalu (7626776)
- A. Morgan (7688165)
- A. P. Morris (7611419)
- A. P. Patel (7725620)
- A. P. Reiner (7626014)
- A. Pattie (7725623)
- A. Pirie (7725632)
- A. R. Van Der Leij (7725680)
- A. R. Wood (7685348)
- A. Rasheed (7605908)
- A. Robino (7725638)
- A. S. Butterworth (7605158)
- A. T. Hattersley (7609073)
- A. Teumer (7609454)
- A. Tybjaerg-Hansen (7605182)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- A. V. Smith (7605131)
- A. Varbo (7725686)
- A. W. Hewitt (7725509)
- A. Y. Chu (7725419)
- A.-E. Farmaki (7632758)
- B. Balkau (7609544)
- B. Banas (7725389)
- B. G. Nordestgaard (7605362)
- B. H. Thuesen (7725668)
- B. Kahali (7725533)
- C. A. Böger (7725401)
- C. A. Wang (7725698)
- C. B. Hoyng (2802346)
- C. Christensen (7652747)
- C. D. Langefeld (7646192)
- C. E. Lewis (7725572)
- C. E. Pennell (7653287)
- C. Hayward (7609304)
- C. J. Packard (7652738)
- C. J. Willer (7611383)
- C. Kooperberg (7689857)
- C. Langenberg (7608872)
- C. M. Lindgren (7611374)
- C. M. van Duijn (7626872)
- C. Medina-Gomez (7653182)
- C. N. A. Palmer (7660355)
- C. Oxvig (7725728)
- C. Schurmann (7725359)
- CHD Exome+ Consortium (7715321)
- Christopher P. Nelson (7625975)
- D. A. Mackey (7725584)
- D. Arveiler (7652327)
- D. F. Easton (7608179)
- D. F. Reilly (7652717)
- D. I. Chasman (7605179)
- D. J. Carey (7725413)
- D. J. Liu (7725725)
- D. J. Thompson (7603073)
- D. Lamparter (7725365)
- D. O. Mook-Kanamori (7725599)
- D. Posthuma (5044979)
- D. R. V. Edwards (7725689)
- D. R. Witte (7725707)
- D. S. Alam (7646294)
- D. Saleheen (7605173)
- D. Vozzi (7725695)
- D. W. Bowden (7725404)
- E. Albrecht (7612112)
- E. B. Larson (7725566)
- E. Boerwinkle (7609103)
- E. Di Angelantonio (7611773)
- E. Evangelou (7626641)
- E. Ferrannini (7725470)
- E. Ingelsson (7605335)
- E. K. Speliotes (7611380)
- E. M. Lange (7725563)
- E. Marouli (7626761)
- E. P. Bottinger (7689854)
- E. Tsafantakis (7636823)
- E. V. Appel (7725386)
- E. W. Demerath (7725446)
- E. Zeggini (7632767)
- EPIC-InterAct Consortium (7725719)
- ExomeBP Consortium (7715327)
- F. Drenos (7602632)
- F. Karpe (7611410)
- F. Kee (3531716)
- F. Renström (7611431)
- F. Rivadeneira (7611509)
- F. S. Collins (7609505)
- F. W. Asselbergs (3801271)
- F. Wang (1690585)
- G. Abecasis (7609514)
- G. B. Jensen (7725524)
- G. Breen (7632803)
- G. Cuellar-Partida (7725434)
- G. Davies (7643840)
- G. Dedoussis (7626908)
- G. Girotto (7725488)
- G. J. de Borst (7698176)
- G. K. Hovingh (3801262)
- G. Lettre (7685792)
- G. M. Peloso (7605836)
- G. Marenne (7632953)
- G. P. Jarvik (7689860)
- G. Pasterkamp (7626023)
- G. Thorleifsson (7606022)
- G. Tromp (7646132)
- Global Lipids Genetics Consortium (7725722)
- GoT2D Genes Consortium (7715333)
- H. Boeing (6548024)
- H. Kitajima (7725548)
- H. Kuivaniemi (7646135)
- H. Li (1597072)
- H. Lin (3462437)
- H. M. Highland (7652729)
- H. M. Stringham (7605209)
- H. Oksa (7652756)
- H. R. Warren (7725701)
- H. Vestergaard (4036871)
- H. Yaghootkar (7652636)
- H. Zheng (2057848)
- I. B. Borecki (7685702)
- I. Brandslund (6446831)
- I. Ford (5772110)
- I. Gandin (7725479)
- I. J. Deary (7620122)
- I. M. Heid (7611266)
- I. Ntalla (7725608)
- I. Rudan (7609409)
- I.-T. Lee (7725569)
- J. A. Perry (7725626)
- J. A. Smith (1888894)
- J. Bork-Jensen (7652663)
- J. C. Chambers (7605185)
- J. C. Florez (7608869)
- J. C. Galbany (7725428)
- J. Corley (7725425)
- J. D. Faul (7725467)
- J. D. Rioux (7725635)
- J. Danesh (7605383)
- J. Ferrieres (7725473)
- J. G. Dennis (7725452)
- J. G. Wilson (7609118)
- J. H. Zhao (1395031)
- J. Hernesniemi (7725506)
- J. I. Rotter (7626935)
- J. Kaprio (7647446)
- J. Kontto (7652669)
- J. Kriebel (7725554)
- J. Kuusisto (7609355)
- J. Li (51350)
- J. Lindström (3847444)
- J. Luan (7609367)
- J. M. M. Howson (7646075)
- J. M. Starr (7620119)
- J. Marten (7652654)
- J. N. Hirschhorn (7609139)
- J. P . Cook (7725422)
- J. P. Tyrer (7725671)
- J. R. B. Perry (7632749)
- J. R. O'Connel (7725611)
- J. S. Kooner (7605356)
- J. Tuomilehto (7611044)
- J. van Setten (7625924)
- J. W. Jukema (7625996)
- J. Wessel (7725704)
- J. Yao (1794466)
- J.-C. Tardif (7725665)
- J.-H. Jansson (7725521)
- K. B. Kluivers (7725551)
- K. D. Taylor (7626905)
- K. E. North (7635935)
- K. E. Stirrups (7626839)
- K. E. Tansey (7725662)
- K. H. Allin (7605359)
- K. HeikkilÀ (7652294)
- K. Hveem (7626929)
- K. K. Aben (7725383)
- K. L. Mohlke (7605866)
- K. L. Young (7725371)
- K. M. Harris (7725500)
- K. Meidtner (7725593)
- K. Nikus (7626950)
- K. R. Owen (7685480)
- K. S. Lo (7725350)
- K. S. Ruth (7725641)
- K. S. Small (7652315)
- K. Sandow (7725644)
- K. Stefansson (7606001)
- L. A. Kiemeney (7619285)
- L. A. Lange (7646105)
- L. Broer (7645085)
- L. E. Bang (7725392)
- L. F. Bielak (7725398)
- L. He (1942591)
- L. J. Hocking (7725512)
- L. L. Bonnycastle (7609496)
- L. Lind (7625984)
- L. M. 't Hart (7725659)
- L. M. O. Loohuis (7725614)
- L. M. Yerges-Armstrong (7725716)
- L. S. Adair (7626569)
- L. Southam (7632728)
- L.-A. Lin (7725578)
- L.-P. LyytikÀinen (7725581)
- M. A. Ikram (7626689)
- M. A. Jhun (7725527)
- M. A. Nalls (7646225)
- M. A. Rivas (7725380)
- M. Allison (6553730)
- M. B. Schulze (7725653)
- M. Benn (7725395)
- M. BlĂŒher (4908460)
- M. Boehnke (7605344)
- M. C. H. de Groot (7725440)
- M. C. Y. Ng (7725374)
- M. Cocca (7632734)
- M. Du (7725455)
- M. E. JĂžrgensen (7725530)
- M. F. Feitosa (7685738)
- M. Fornage (7609064)
- M. Gorski (7626956)
- M. Graff (7725347)
- M. H. Brilliant (7725407)
- M. Hollensted (7725515)
- M. I. McCarthy (7609121)
- M. J. Caulfield (7602383)
- M. K. Schmidt (7658327)
- M. Karaleftheri (7636826)
- M. KÀhönen (3495260)
- M. L. Bots (7686470)
- M. L. Grove (7725497)
- M. La Bianca (7725560)
- M. Laakso (7609358)
- M. M. Ferrario (7652330)
- M. MĂŒller-Nurasyid (7626752)
- M. Nauck (6643733)
- M. Neville (7725602)
- M. O. Woods (7725710)
- M. P. Segura-Lepe (7725656)
- M. Perola (7605860)
- M. Stumvoll (7609448)
- M. Walker (1291794)
- MAGIC Investigators (7698314)
- N. G. Martin (7639949)
- N. Grarup (7627439)
- N. J. Samani (7591811)
- N. J. Wareham (7608962)
- N. L. Heard-Costa (7698326)
- N. M. van Schoor (7725683)
- N. Robertson (61307)
- N. Sattar (7608890)
- Nicholas G. D. Masca (7672691)
- O. L. Holmen (7626680)
- O. Pedersen (7627493)
- O. Polasek (7609424)
- O. Rolandsson (7652735)
- O. T. Raitakari (7647452)
- P. A. F. Madden (7725587)
- P. Amouyel (7605287)
- P. B. Munroe (7602386)
- P. Deloukas (7603691)
- P. Elliott (1293702)
- P. Gasparini (7725482)
- P. Gordon-Larsen (7725494)
- P. I. W. de Bakker (7605305)
- P. J. Schreiner (7725650)
- P. Jousilahti (7611407)
- P. Komulainen (4753311)
- P. Kovacs (7609346)
- P. L. Auer (7689797)
- P. L. Huang (7725518)
- P. L. Peissig (7646156)
- P. M. Ridker (7605368)
- P. Mitchell (7725596)
- P. Mudgal (7725377)
- P. R. Kamstrup (7725539)
- P. R. NjĂžlstad (7725605)
- P. Surendran (7652621)
- P. T. Ellinor (7725464)
- P. W. Franks (7605191)
- P. Yao (7725713)
- R. A. Ophoff (7725617)
- R. A. Scott (2840021)
- R. Chowdhury (7646300)
- R. de Mutsert (7725443)
- R. Frikke-Schmidt (7605842)
- R. J. F. Loos (7725731)
- R. Keeman (7725545)
- R. Li-Gao (7725575)
- R. Rauramaa (7626923)
- R. S. Fine (7725356)
- R. S. Kahn (7725536)
- R. Uher (7725674)
- R. Varma (7695929)
- R. Young (7646078)
- ReproGen Consortium (7715342)
- S. A. Lubitz (7646210)
- S. Bergmann (7612121)
- S. D. Gordon (7725491)
- S. de Denus (7725437)
- S. F. Nielsen (7646099)
- S. Feng (2571244)
- S. Gustafsson (7698278)
- S. H. Vermeulen (7725692)
- S. Johansson (4737543)
- S. Kanoni (7626542)
- S. Kathiresan (7606013)
- S. KĂŒry (7725557)
- S. L. R. Kardia (7725542)
- S. M. Willems (7647404)
- S. MÀnnistö (7626749)
- S. Padmanabhan (637530)
- S. RĂŒeger (7725362)
- S. Shah (4421101)
- S. Sivapalaratnam (7604441)
- S. Trompet (7625936)
- S. Ulivi (7725677)
- S. Vedantam (7698287)
- S. W. van der Laan (7625912)
- S. Wang (673797)
- T. A. Lakka (7626731)
- T. B. Harris (7605353)
- T. D. Spector (7608968)
- T. E. Galesloot (7625930)
- T. Ebeling (7725458)
- T. Esko (7626638)
- T. F. Vogt (7652723)
- T. H. Pers (7626953)
- T. Hansen (3919604)
- T. JĂžrgensen (7627442)
- T. Karaderi (6553712)
- T. Kocher (5864939)
- T. L. Edwards (7725461)
- T. LehtimÀki (3495257)
- T. M. Frayling (7608959)
- T. N. Person (7725629)
- T. R. Kjaer (7725353)
- T. V. Varga (7652696)
- T. W. Winkler (7647401)
- T2D-Genes Consortium (7715348)
- U. Thorsteinsdottir (7606031)
- V. Giedraitis (7625945)
- V. Gudnason (7605347)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- V. Turcot (7725368)
- V. Vitart (7609463)
- W. Gan (7725476)
- W. Zhang (820655)
- W. Zhao (696097)
- W. Zhou (1551811)
- X. Guo (1820437)
- X. Jiang (1784158)
- X. Lin (3771379)
- X. Sim (7626824)
- X. Zhan (1504810)
- Y. Jia (2014003)
- Y. Liu (543492)
- Y. Lu (1469287)
- Y. Sapkota (7725647)
- Y. Wang (473169)
- Y. Wu (1590877)
- Y.-D. I. Chen (7725416)
- Z. Kutalik (7626725)
- Ă. Helgeland (7725503)
- Publication venue
- Publication date
- 01/02/2017
- Field of study
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2âcentimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2âcentimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
- Author
- A. Adeyemo (7778594)
- A. B. Zonderman (7778600)
- A. C. Morrison (7625951)
- A. D. Johnson (7626965)
- A. Dehghan (7626011)
- A. Demirkan (7670795)
- A. F. Wright (7609490)
- A. Franke (7412741)
- A. G. Uitterlinden (7611476)
- A. Hofman (4269889)
- A. Isaacs (7647437)
- A. K. Dieffenbach (7778597)
- A. Köttgen (7609343)
- A. Lupo (7778612)
- A. Metspalu (7626776)
- A. Parsa (7626662)
- A. R. Shuldiner (7685708)
- A. Robino (7725638)
- A. Saint-Pierre (7778639)
- A. Teumer (7609454)
- A. Tin (7778570)
- A. Tonjes (7778609)
- A. V. Smith (7605131)
- A. W. Dreisbach (7778606)
- A. Y. Chu (7725419)
- AGEN Consortium (7778765)
- B. A. Oostra (7611425)
- B. D. Mitchell (7685618)
- B. I. Freedman (7778618)
- B. K. KrÀmer (7778624)
- B. Kollerits (7778615)
- B. M. Buckley (7610990)
- B. Paulweber (7685405)
- B. Ponte (7778621)
- B. Stengel (1741084)
- B. Tayo (7778588)
- B. W. Penninx (7611212)
- C. A. Böger (7725401)
- C. A. Peralta (7778627)
- C. Fuchsberger (7683191)
- C. Gieger (7609259)
- C. Hayward (7609304)
- C. Helmer (5354324)
- C. M. Shaffer (7737461)
- C. M. Van Duijn (7778636)
- C. Meisinger (3995486)
- C. MĂŒller (2693209)
- C. N. Rotimi (7778630)
- C. Pattaro (7670822)
- C. S. Fox (7609280)
- C. Sala (7778633)
- CARDIOGRAM (7778768)
- CHARGe-Heart Failure Group (7778771)
- D. Ackermann (7778642)
- D. Cusi (7602533)
- D. Czamara (7778654)
- D. Ellinghaus (7760321)
- D. I. Chasman (7605179)
- D. Ruderfer (7778657)
- D. Ruggiero (7778648)
- D. S. Siscovick (7611209)
- D. Shriner (7778645)
- D. Taliun (7654799)
- D. Toniolo (7778651)
- E. Boerwinkle (7609103)
- E. G. Holliday (7650320)
- E. J. Atkinson (7778663)
- E. P. Bottinger (7689854)
- E. Rochtchina (7778660)
- E. Salvi (7602497)
- ECHOGen Consortium (7778774)
- F. B. Hu (7611461)
- F. Ernst (3719323)
- F. Kronenberg (7611272)
- F. Murgia (7778666)
- F. Rivadeneira (7611509)
- G-A. Thun (7778672)
- G. B. Ehret (7626533)
- G. C. Curhan (7778669)
- G. Eiriksdottir (7650329)
- G. Gambaro (7632764)
- G. Homuth (7609310)
- G. J. Navis (3694978)
- G. Jacobs (7778675)
- G. Li (2960067)
- G. Malerba (7632719)
- G. Pistis (7737452)
- G. W. Montgomery (7652342)
- H-E. Wichmann (7611602)
- H. Brenner (3531743)
- H. Campbell (7609436)
- H. Grallert (4107469)
- H. K. Kroemer (7778678)
- H. Kramer (1862254)
- H. Lin (3462437)
- H. Schmidt (3956999)
- H. Snieder (7611185)
- H. Völzke (6643736)
- H. Wallaschofski (7609466)
- I. Borecki (7778687)
- I. Ford (5772110)
- I. Guessous (7778684)
- I. H. de Boer (7778831)
- I. Kolcic (7650395)
- I. M. Heid (7611266)
- I. M. Leach (7778681)
- I. M. Nolte (3809176)
- I. Persico (7778690)
- I. Prokopenko (7608875)
- I. Rudan (7609409)
- ICBP Consortium (7778762)
- J-C. Lambert (7778696)
- J-M. Gaspoz (7778702)
- J. A. Smith (1888894)
- J. Attia (7778705)
- J. B. Whitfield (7612142)
- J. C. Denny (7737386)
- J. Chalmers (7611284)
- J. Coresh (7609520)
- J. D. Faul (7725467)
- J. Ding (2126038)
- J. Divers (7778693)
- J. F. Felix (7625948)
- J. F. Wilson (7605311)
- J. H. Smit (7626827)
- J. J. Wang (3956015)
- J. K. Fernandes (7778711)
- J. Karjalainen (7778708)
- J. M. Stafford (7778699)
- J. N. Hirschhorn (7609139)
- J. R. OâConnell (7778822)
- J. Tremblay (7778828)
- J. Viikari (7685345)
- J. W. Jukema (7625996)
- K. Butterbach (7778717)
- K. Endlich (7778714)
- K. L. Keene (7778720)
- K. Lohman (7643855)
- K. Susztak (7778825)
- L-P. LyytikÀinen (7653245)
- L. Ferrucci (7608902)
- L. Franke (7602401)
- L. J. Launer (7643819)
- L. Kedenko (7685354)
- L. M. Rose (7685768)
- L. Portas (7778723)
- L. Yengo (7626668)
- M. A. McEvoy (7778738)
- M. Adam (7217573)
- M. Boban (7719263)
- M. Bochud (7611158)
- M. C. Cornelis (7778729)
- M. Cavalieri (7778726)
- M. Ciullo (7778732)
- M. Cocca (7632734)
- M. de Andrade (7646150)
- M. E. Kleber (7605227)
- M. F. Feitosa (7685738)
- M. Foster (7778579)
- M. Garnaas (7778567)
- M. Gorski (7626956)
- M. H. Chen (7778582)
- M. Haun (7628735)
- M. Imboden (3809185)
- M. K. Evans (7778744)
- M. KÀhönen (3495260)
- M. Li (621494)
- M. M. Sale (7778747)
- M. Metzger (7682627)
- M. Nalls (7648394)
- M. Nauck (6643733)
- M. Olden (7778576)
- M. Pirastu (7778735)
- M. Pruijm (7778741)
- M. Rao (5581496)
- M. Rheinberger (7778750)
- M. Struchalin (7670831)
- M. Stumvoll (7609448)
- M. Waldenberger (7625939)
- M. Woodward (7605239)
- N. Bouatia-Naji (7609265)
- N. G. Martin (7639949)
- N. Hastie (7778753)
- N. Probst-Hensch (3809206)
- N. Soranzo (7608857)
- N. Verweij (7652687)
- O. Devuyst (7778756)
- O. Gottesman (7646165)
- O. H. Franco (7625993)
- O. Polasek (7609424)
- O. Raitakari (3495236)
- P. B. Munroe (7602386)
- P. D'Adamo (7778591)
- P. Froguel (7609517)
- P. Gasparini (7725482)
- P. Hamet (7611302)
- P. J. Van Der Most (7778603)
- P. Kovacs (7609346)
- P. M. Ridker (7605368)
- P. Mitchell (7725596)
- P. Muntner (7778759)
- P. P. Pramstaller (7626770)
- P. S. Wild (7603637)
- Q. Yang (1714945)
- R. Biffar (7778777)
- R. J. Carroll (7778783)
- R. J. F. Loos (7725731)
- R. J. Scott (7650368)
- R. Katz (7778786)
- R. MĂ€gi (7609376)
- R. P. S. Middelberg (7778780)
- R. Rettig (7611203)
- R. Schmidt (7703903)
- R. Sorice (7778573)
- S-J. Hwang (7778789)
- S. Coassin (7685315)
- S. E. Rosas (7778801)
- S. Enroth (7626632)
- S. H. Wild (7609475)
- S. J. Hancock (7778795)
- S. Kloiber (7778792)
- S. L. R. Kardia (7725542)
- S. Sedaghat (7625921)
- S. Stracke (7778804)
- S. T. Turner (7778798)
- S. Trompet (7625936)
- S. Ulivi (7725677)
- T. Aspelund (7650338)
- T. B. Harris (7605353)
- T. Esko (7626638)
- T. H. Pers (7626953)
- T. Illig (7609322)
- T. LehtimÀki (3495257)
- T. Nikopensius (7778807)
- T. Tanaka (3979952)
- T. Zeller (7603634)
- T. Zemunik (7650392)
- U. Gyllensten (7612145)
- U. Völker (7612136)
- V. Aalto (7778813)
- V. Chouraki (7778816)
- V. Emilsson (7778810)
- V. Gudnason (7605347)
- V. Mijatovic (7626779)
- V. Vitart (7609463)
- W-M. Chen (7778819)
- W. Goessling (7778834)
- W. H. L. Kao (7778837)
- W. Igl (7670837)
- W. Koenig (7605212)
- W. Lieb (7412738)
- W. MĂ€rz (7609394)
- Y. A. Ko (7778585)
- Y. Li (696089)
- Y. Liu (543492)
- Y. Lu (1469287)
- Ă . Johansson (7670804)
- Publication venue
- Publication date
- 21/01/2016
- Field of study
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways
Sex-stratified genoSex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
- Author
- A. A. Hicks (7626671)
- A. Bonnefond (7609472)
- A. D. Morris (7611470)
- A. E. Locke (7698281)
- A. G. Uitterlinden (7611476)
- A. Ganna (7698407)
- A. Goel (7602413)
- A. Hamsten (7602395)
- A. Hingorani (7608893)
- A. Hofman (4269889)
- A. J. Swift (7609451)
- A. Johansson (5505674)
- A. Jula (7609328)
- A. L. Hartikainen (7626647)
- A. Maschio (7698332)
- A. Metspalu (7626776)
- A. P. Attwood (7698338)
- A. Peters (6004598)
- A. R. Shuldiner (7685708)
- A. R. Wood (7685348)
- A. S. Dimas (7698293)
- A. S. Hall (7605176)
- A. Scherag (7698284)
- A. T. Kraja (7652651)
- A. Teumer (7609454)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- A. V. Smith (7605131)
- A. Wong (7602695)
- B . Penninx (7698329)
- B. A. Oostra (7611425)
- B. Gigante (7606052)
- B. O. Boehm (7660346)
- B. R. Winkelmann (7640576)
- B. Thorand (3531725)
- C. Barlassina (7682495)
- C. Buechler (7698308)
- C. Gieger (7609259)
- C. Hayward (7609304)
- C. Hengstenberg (7603694)
- C. Iribarren (7626692)
- C. Lamina (7611263)
- C. Langenberg (7608872)
- C. Loley (7640549)
- C. M. Lindgren (7611374)
- C. M. van Duijn (7626872)
- C. Medina-Gomez (7653182)
- C. N. Palmer (7611428)
- C. Ohlsson (7605323)
- C. Power (7601459)
- C. Rivolta (7698353)
- C. S. Fox (7609280)
- D. Absher (7626566)
- D. Anderson (7617611)
- D. Arveiler (7652327)
- D. C. Croteau-Chonka (7685753)
- D. Hunter (7671956)
- D. I. Boomsma (1812745)
- D. I. Chasman (7605179)
- D. J. Clegg (7698299)
- D. Kuh (7602698)
- D. P. Strachan (3809152)
- D. Schlessinger (7609430)
- D. Shungin (7626677)
- DIAGRAM Consortium (7670852)
- E. Albrecht (7612112)
- E. Hyppönen (7652300)
- E. Ingelsson (7605335)
- E. K. Speliotes (7611380)
- E. Mihailov (7645184)
- E. Rehnberg (7698410)
- E. T. Dermitzakis (7698290)
- E. Tremoli (7626857)
- F. Karpe (7611410)
- F. R. Day (7698275)
- F. Rivadeneira (7611509)
- F. S. Collins (7609505)
- G. Boucher (7698341)
- G. Cesana (7611188)
- G. Dedoussis (7626908)
- G. Fowkes (7698185)
- G. Hallmans (7626623)
- G. Kolovou (7626710)
- G. Li (2960067)
- G. Navis (7611155)
- G. Nicholson (7698296)
- G. R. Abecasis (7602524)
- G. Thorleifsson (7606022)
- G. W. Montgomery (7652342)
- H. Basart (7604444)
- H. Campbell (7609436)
- H. E. Wichmann (7608932)
- H. Grallert (4107469)
- H. Grönberg (7698320)
- H. Huikuri (7698344)
- H. Sager (7698380)
- H. Schunkert (7603670)
- H. Snieder (7611185)
- H. Völzke (6643736)
- I. B. Borecki (7685702)
- I. Barroso (7609532)
- I. M. Heid (7611266)
- I. M. Nolte (3809176)
- I. Mateo Leach (7698371)
- I. Mathieson (7632950)
- I. NjĂžlstad (3531731)
- I. Prokopenko (7608875)
- I. Rudan (7609409)
- I. Surakka (7606076)
- J. C. Randall (7611377)
- J. Erdmann (7603664)
- J. F. Price (7609154)
- J. F. Wilson (7605311)
- J. G. Eriksson (7647449)
- J. G. Sambrook (7693379)
- J. H. Zhao (1395031)
- J. Hui (6291092)
- J. Hung (7605338)
- J. J. Hottenga (7609313)
- J. Jolley (7693382)
- J. Kaprio (7647446)
- J. Kuusisto (7609355)
- J. L. Bolton (7698383)
- J. L. Min (7632713)
- J. Lindström (3847444)
- J. Luan (7609367)
- J. N. Hirschhorn (7609139)
- J. P. Beilby (7685573)
- J. P. Krohn (7698305)
- J. R. O'Connell (7698419)
- J. S. Beckmann (7612118)
- J. Saramies (7626809)
- J. Shi (1478902)
- J. Sinisalo (6254942)
- J. Tuomilehto (7611044)
- J. Tyrer (7698335)
- J. V. Van Vliet-Ostaptchouk (7698359)
- J. Virtamo (7626887)
- J. W. Yarnell (7685687)
- J. Yang (1558195)
- K. B. Jacobs (7698365)
- K. E. North (7635935)
- K. Eisinger (7698311)
- K. Estrada (7611392)
- K. Fischer (802664)
- K. G. Hovingh (7698377)
- K. Hveem (7626929)
- K. K. Ong (7626608)
- K. Kristiansson (7626782)
- K. KrjutÄ Kov (7698386)
- K. Kuulasmaa (3531734)
- K. L. Mohlke (7605866)
- K. L. Monda (7698269)
- K. Stefansson (7606001)
- K. Stirrups (7683206)
- K. T. Khaw (7609508)
- L. A. Cupples (7605977)
- L. A. Kiemeney (7619285)
- L. C. Groop (7685801)
- L. J. Palmer (7608638)
- L. L. Bonnycastle (7609496)
- L. L. Waite (7698317)
- L. Liang (6079640)
- L. Lind (7625984)
- L. M. Rose (7685768)
- L. Qi (2057833)
- M. A. Province (7685642)
- M. Atalay (7653284)
- M. Boehnke (7605344)
- M. C. Zillikens (7611512)
- M. den Heijer (7583045)
- M. Dimitriou (7698404)
- M. E. Kleber (7605227)
- M. F. Feitosa (7685738)
- M. Farrall (6522599)
- M. I. McCarthy (7609121)
- M. J. Caulfield (7602383)
- M. Kivimaki (7602458)
- M. Kumari (7602503)
- M. L. Lokki (7685789)
- M. Laakso (7609358)
- M. Lorentzon (7698347)
- M. M. Nöthen (7698398)
- M. M. Van der Klauw (7698356)
- M. Mangino (7609385)
- M. MĂŒller-Nurasyid (7626752)
- M. Perola (7605860)
- M. R. Jarvelin (7611464)
- M. Teder-Laving (7698323)
- M. Uusitupa (7626860)
- MAGIC Investigators (7698314)
- N. Amin (7611452)
- N. Eklund (7698350)
- N. G. Martin (7639949)
- N. J. Samani (7591811)
- N. J. Wareham (7608962)
- N. L. Heard-Costa (7698326)
- N. L. Pedersen (7609403)
- N. Narisu (7609415)
- O. Raitakari (3495236)
- P. B. Munroe (7602386)
- P. Deloukas (7603691)
- P. E. Schwarz (7603253)
- P. Froguel (7609517)
- P. Hall (7508258)
- P. K. Magnusson (7609379)
- P. Kovacs (7609346)
- P. M. Ridker (7605368)
- P. P. Pramstaller (7626770)
- P. S. Chines (7626599)
- P. V. Gejman (7698362)
- P. van der Harst (7594607)
- P. W. Franks (7605191)
- R. Erbel (7689842)
- R. J. Loos (7608845)
- R. J. Strawbridge (7626656)
- R. Kaplan (7698416)
- R. M. Fraser (7626821)
- R. MĂ€gi (7609376)
- R. Rauramaa (7626923)
- S. Bauer (642421)
- S. E. Humphries (7602692)
- S. E. Medland (7698374)
- S. Edkins (7626626)
- S. Gustafsson (7698278)
- S. I. Berndt (7698266)
- S. J. Bakker (7698368)
- S. J. Chanock (7611530)
- S. Kanoni (7626542)
- S. Kathiresan (7606013)
- S. Li (1624891)
- S. M. Keinanen-Kiukaanniemi (7698389)
- S. Moebus (7698395)
- S. Pechlivanis (7698401)
- S. R. Bornstein (7609526)
- S. Ripatti (7606073)
- S. Vedantam (7698287)
- T. A. Lakka (7626731)
- T. B. Harris (7605353)
- T. D. Spector (7608968)
- T. E. Saaristo (7698392)
- T. Esko (7626638)
- T. Fall (7625915)
- T. Ferreira (3480845)
- T. Frayling (7698413)
- T. Haritunians (7685798)
- T. Illig (7609322)
- T. Johnson (7602368)
- T. L. Assimes (7605317)
- T. LehtimÀki (3495257)
- T. O. KilpelÀinen (7683194)
- T. Person (7698302)
- T. W. Winkler (7647401)
- T. Wilsgaard (3474971)
- T. Workalemahu (7698272)
- U. de Faire (7605206)
- U. Gyllensten (7612145)
- U. Thorsteinsdottir (7606031)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- W. Koenig (7605212)
- W. L. McArdle (7609397)
- W. MĂ€rz (7609394)
- Y. D. Chen (5184422)
- Z. Kutalik (7626725)
- Z. Wang (70993)
- Publication venue
- Publication date
- 06/06/2013
- Field of study
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5Ă10(-8)), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
- Author
- A-C. SyvÀnen (7785878)
- A-E. Farmaki (7737392)
- A. A. Hicks (7626671)
- A. Bonnefond (7609472)
- A. C. Alves (7635926)
- A. C. Ham (7785788)
- A. C. Heath (7652336)
- A. Chakravarti (7626947)
- A. Demirkan (7670795)
- A. E. Justice (7652732)
- A. F. Wright (7609490)
- A. G. Uitterlinden (7611476)
- A. Goel (7602413)
- A. Hamsten (7602395)
- A. Hingorani (7608893)
- A. Hofman (4269889)
- A. J. M. de Craen (7785692)
- A. J. Oldehinkel (7785923)
- A. J. Swift (7609451)
- A. Jula (7609328)
- A. K. Henders (7785794)
- A. L. James (7628765)
- A. L. M. Verbeek (7785941)
- A. Linneberg (3444095)
- A. Mahajan (7603748)
- A. Metspalu (7626776)
- A. P. Morris (7611419)
- A. Palotie (7632986)
- A. Peters (6004598)
- A. Pouta (7650326)
- A. R. Sanders (7785863)
- A. R. Shuldiner (7685708)
- A. S. Buchman (7785761)
- A. S. Go (7785782)
- A. Silveira (7609433)
- A. StanÄĂĄkovĂĄ (7626836)
- A. T. Hattersley (7609073)
- A. Teumer (7609454)
- A. Tremblay (7785884)
- A. Tönjes (7609457)
- A. U. Jackson (7609325)
- A. V. Smith (7605131)
- A. W. Musk (3965711)
- A. Wong (7602695)
- arcOGEN Consortium (7747979)
- B. A. Oostra (7611425)
- B. D. Mitchell (7685618)
- B. Feenstra (7653266)
- B. Gigante (7606052)
- B. Lehne (7785719)
- B. M. Psaty (7605224)
- B. McKnight (7785722)
- B. O. Boehm (7660346)
- B. Sennblad (7698149)
- B. Stefania (7785938)
- B. Thorand (3531725)
- B. W. Penninx (7611212)
- C. A. Böger (7725401)
- C. A. Hartman (7785791)
- C. Barlassina (7682495)
- C. Bellis (3485024)
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- Ă . Johansson (7670804)
- Publication venue
- Publication date
- 29/06/2016
- Field of study
The arcOGEN Consortium should be listed as an author of this article. They contributed to the genome-wide association study results presented in this work. They should be listed in the author byline at position 292 and affiliated with The Arthritis Research UK Osteoarthritis Genetics Consortium. They should also be included in the footnote designating consortia which is underneath the author affiliation list in the PDF version of the article, and in the S2 Text. Please view the correct S2 Text below, containing correct consortia members. S2 Text. Consortia members and extended acknowledgments.
https://doi.org/10.1371/journal.pgen.1006166.s001
(DOCX) [This corrects the article DOI: 10.1371/journal.pgen.1005378.]
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
- Author
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- I. Barroso (7609532)
- I. Chen (7685342)
- I. M. Heid (7611266)
- I. M. Stylianou (7685726)
- I. Meulenbelt (7685399)
- I. N. Day (7611455)
- I. Pichler (7648376)
- I. Prokopenko (7608875)
- I. R. König (7608923)
- I. Rudan (7609409)
- I. Surakka (7606076)
- J. B. Borja (7685372)
- J. B. McAteer (7685612)
- J. B. Meigs (7608965)
- J. B. Richards (7608833)
- J. B. Whitfield (7612142)
- J. Brody (7685339)
- J. C. Bis (7625957)
- J. C. Florez (7608869)
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- J. D. Smith (7685756)
- J. Delplanque (7685585)
- J. Dupuis (7608866)
- J. Erdmann (7603664)
- J. F. Peden (7602416)
- J. F. Wilson (7605311)
- J. G. Eriksson (7647449)
- J. G. Wilson (7609118)
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- J. Grimsby (7685327)
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- J. J. Kastelein (7685828)
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- J. Kooner (7609340)
- J. Kuusisto (7609355)
- J. Luan (7609367)
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- K. O. Kyvik (7639958)
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- K. Song (7608860)
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- L. Ferrucci (7608902)
- L. Groop (7609070)
- L. J. Coin (7685576)
- L. J. Launer (7643819)
- L. J. McCulloch (7685417)
- L. J. Palmer (7608638)
- L. J. Rasmussen-Torvik (7646174)
- L. J. Scott (7611437)
- L. Kedenko (7685354)
- L. L. Bonnycastle (7609496)
- L. Lind (7625984)
- L. M. Kaplan (7685795)
- L. M. Rose (7685768)
- L. P. LyytikÀinen (7626830)
- L. Peltonen (7606004)
- L. Qi (2057833)
- L. S. Adair (7626569)
- L. Simpson (7685654)
- M. A. Allison (7685393)
- M. A. Morken (7609412)
- M. A. Province (7685642)
- M. Barbalic (7605845)
- M. Beekman (7645079)
- M. Bochud (7611158)
- M. Boehnke (7605344)
- M. C. Zillikens (7611512)
- M. Cornelis (7685450)
- M. F. Feitosa (7685738)
- M. F. Hivert (7608842)
- M. G. Franzosi (7602410)
- M. Ganser (7685459)
- M. Garcia (7650347)
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- M. I. McCarthy (7609121)
- M. J. Caulfield (7602383)
- M. J. Daly (7605926)
- M. J. Go (7685744)
- M. J. Neville (7652672)
- M. J. Sampson (7685489)
- M. Kaakinen (7626740)
- M. Kivimaki (7602458)
- M. Kloppenburg (7685369)
- M. Koseki (7685729)
- M. Kumari (7602503)
- M. KÀhönen (3495260)
- M. L. Lokki (7685789)
- M. L. Nuotio (7652288)
- M. Laakso (7609358)
- M. Ladouceur (7685324)
- M. Li (621494)
- M. Mangino (7609385)
- M. Marmot (7611368)
- M. Marre (7611293)
- M. N. Cooper (7685579)
- M. N. Weedon (7611449)
- M. O. Goodarzi (7626941)
- M. Orho-Melander (7605839)
- M. OrrĂč (7685624)
- M. P. Reilly (7605332)
- M. Perola (7605860)
- M. R. Erdos (7611389)
- M. R. Jarvelin (7611464)
- M. Rieder (7685771)
- M. Roden (7609388)
- M. S. Nieminen (7605854)
- M. S. Sandhu (7609271)
- M. Sandhu (7636817)
- M. Seielstad (7685810)
- M. Serrano-RĂos (7609400)
- M. Stumvoll (7609448)
- M. T. MartĂnez-Larrad (7609391)
- M. Uda (7609529)
- M. van Hoek (7685429)
- M. Walker (1291794)
- MAGIC Consortium (7685378)
- MAGIC investigators (7685720)
- MuTHER Consortium (7685384)
- N. Amin (7611452)
- N. B. Freimer (7685804)
- N. Bouatia-Naji (7609265)
- N. D. Hastie (7650311)
- N. G. Forouhi (7611395)
- N. G. Martin (7639949)
- N. Grarup (7627439)
- N. Hammond (7685597)
- N. Hassanali (7685465)
- N. J. Timpson (7608851)
- N. J. Wareham (7608962)
- N. Klopp (7611599)
- N. L. Glazer (7685534)
- N. L. Pedersen (7609403)
- N. L. Smith (7646216)
- N. Narisu (7609415)
- N. P. Burtt (7605932)
- N. R. Robertson (7647422)
- N. Sattar (7608890)
- N. Soranzo (7608857)
- N. Timpson (7685309)
- N. Vogelzangs (7685675)
- N. W. Rayner (7626794)
- Nilesh Jayantilal Samani (7629899)
- O. D. Carlson (7685351)
- O. Le Bacquer (7685609)
- O. M. Hofmann (7685426)
- O. Melander (7602683)
- O. Pedersen (7627493)
- O. Polasek (7609424)
- O. Raitakari (3495236)
- O. Rolandsson (7652735)
- P. An (7685552)
- P. B. Munroe (7602386)
- P. Barter (7608935)
- P. Chines (7611539)
- P. Deloukas (7603691)
- P. E. Slagboom (7645244)
- P. Elliott (1293702)
- P. Froguel (7609517)
- P. Galan (7645211)
- P. Henneman (5044997)
- P. J. Wagner (7685678)
- P. K. Magnusson (7609379)
- P. Kovacs (7609346)
- P. Kraft (7685471)
- P. M. Ridker (7605368)
- P. Meneton (7626773)
- P. Navarro (1693129)
- P. Nilsson (3701965)
- P. P. Pramstaller (7626770)
- P. R. Johnson (7685468)
- P. S. Chines (7626599)
- P. Scheet (7611473)
- P. Schwarz (7609334)
- P. Sethupathy (7685567)
- P. Shrader (7609421)
- P. Vollenweider (4002164)
- P. W. Franks (7605191)
- Procardis Consortium (7685711)
- Q. Sun (1373196)
- R. A. Hegele (7685825)
- R. A. Scott (2840021)
- R. Benediktsson (7685435)
- R. Blagieva (7685438)
- R. Clarke (7602407)
- R. Frants (7685333)
- R. Gwilliam (7685594)
- R. J. Loos (7608845)
- R. Laaksonen (7640441)
- R. Luben (3537284)
- R. M. Krauss (7626722)
- R. M. Roccasecca (7685561)
- R. M. van Dam (7685504)
- R. M. Watanabe (7685531)
- R. Mahley (7608938)
- R. McPherson (7605974)
- R. MĂ€gi (7609376)
- R. N. Bergman (7611524)
- R. P. Tracy (7605272)
- R. P. Welch (7685411)
- R. Pakyz (7685627)
- R. Roberts (2820928)
- R. Saxena (7608878)
- R. Semple (7685390)
- R. Sladek (7608881)
- R. T. Ong (7685750)
- R. Y. Zee (7685759)
- S. A. McCarroll (7685423)
- S. B. Gabriel (7609124)
- S. Bandinelli (7611518)
- S. Bergmann (7612121)
- S. Bumpstead (7609550)
- S. Böhringer (3171543)
- S. C. Heath (7685600)
- S. C. Potter (7685639)
- S. Cauchi (7685516)
- S. Coassin (7685315)
- S. Demissie (7605914)
- S. Ebrahim (7611557)
- S. G. Buxbaum (7685396)
- S. Griffin (3537278)
- S. Grundy (7608929)
- S. H. Wild (7609475)
- S. Hadjadj (7685462)
- S. Hercberg (4444465)
- S. J. Bumpstead (7611527)
- S. J. Sharp (7619756)
- S. Kanoni (7626542)
- S. Kathiresan (7606013)
- S. Koskinen (4172086)
- S. L. Ricketts (7608920)
- S. M. Boekholdt (7611776)
- S. M. Willems (7647404)
- S. Mukherjee (1671667)
- S. Musani (7685387)
- S. Naitza (7685621)
- S. R. Bornstein (7609526)
- S. Raychaudhuri (7685420)
- S. Redline (7650362)
- S. Ripatti (7606073)
- S. Sanna (7609256)
- S. Visvikis-Siest (7685672)
- S. W. Fouchier (7685735)
- T. A. Buchanan (7685714)
- T. B. Harris (7605353)
- T. D. Spector (7608968)
- T. Ferreira (3480845)
- T. Green (7607897)
- T. Hansen (3919604)
- T. Haritunians (7685798)
- T. Harris (7640504)
- T. Illig (7609322)
- T. Johnson (7602368)
- T. JĂžrgensen (7627442)
- T. L. Assimes (7605317)
- T. Lajunen (7685543)
- T. Lauritzen (7584572)
- T. LehtimÀki (3495257)
- T. M. Frayling (7608959)
- T. M. Teslovich (7683197)
- T. Meitinger (14191)
- T. Park (7685747)
- T. Quertermous (7626788)
- T. SparsĂž (7685498)
- T. T. Valle (7685717)
- T. Tanaka (3979952)
- T. Tuomi (7611443)
- T. van Herpt (7685510)
- T. W. van Haeften (7685507)
- T. W. Winkler (7647401)
- T. Y. Wong (7626602)
- U. de Faire (7605206)
- U. Gyllensten (7612145)
- U. Seedorf (7602437)
- U. Sovio (7685657)
- U. Thorsteinsdottir (7606031)
- V. E. Mooser (7609406)
- V. Gudnason (7605347)
- V. Lyssenko (7609370)
- V. Mooser (7606070)
- V. Salomaa (7605350)
- V. Steinthorsdottir (7609442)
- V. Vitart (7609463)
- W. A. Hide (7685522)
- W. H. Kao (7609523)
- W. Igl (7670837)
- W. McArdle (7685780)
- W. Rathmann (3531737)
- W. Zhang (820655)
- X. Guo (1820437)
- X. Han (3042561)
- X. Li (536560)
- X. Sim (7626824)
- X. Yuan (696093)
- Y. A. Kesaniemi (7608941)
- Y. Ariyurek (7685570)
- Y. Ben-Shlomo (7605296)
- Y. Böttcher (7609547)
- Y. D. Chen (5184422)
- Y. J. Kim (1781752)
- Y. Li (696089)
- Y. Liu (543492)
- Y. S. Aulchenko (7611497)
- Y. S. Cho (7685741)
- Y. Wu (1590877)
- Z. Dastani (7685306)
- Ă . Johansson (7670804)
- Publication venue
- Publication date
- 29/03/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (Pâ=â4.5Ă10(-8)-1.2Ă10(-43)). Using a novel method to combine data across ethnicities (Nâ=â4,232 African Americans, Nâ=â1,776 Asians, and Nâ=â29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3Ă10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (pâ=â4.3Ă10(-3), nâ=â22,044), increased triglycerides (pâ=â2.6Ă10(-14), nâ=â93,440), increased waist-to-hip ratio (pâ=â1.8Ă10(-5), nâ=â77,167), increased glucose two hours post oral glucose tolerance testing (pâ=â4.4Ă10(-3), nâ=â15,234), increased fasting insulin (pâ=â0.015, nâ=â48,238), but with lower in HDL-cholesterol concentrations (pâ=â4.5Ă10(-13), nâ=â96,748) and decreased BMI (pâ=â1.4Ă10(-4), nâ=â121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance