Optimization of Process Parameters of Al-Si Alloy by Centrifugal Casting Technique Using Taguchi Design of Experiments

AbstractIn this paper, the influence of process parameters on the mechanical properties during centrifugal casting of aluminum alloy (4600) is studied. Taguchi method of design of experiments was employed to optimize the process parameters and to increase the mechanical properties. The investigation has indicated that increase in pouring temperature reduces mechanical properties while increase in die speed increases mechanical properties and density. Results were analyzed using ANOVA technique to know the percentage of contribution of each casting process parameters. Microstructures were studied under optical microscope and SEM were analyzed with process parameters by correlating with the mechanical properties of as cast structures

Mutations at the Subunit Interface of Yeast Proliferating Cell Nuclear Antigen Reveal a Versatile Regulatory Domain

Acknowledgments We thank Szilvia Minorits for technical assistance. I.U. conceived and designed the project and wrote the manuscript. All authors participated in designing and performing the experiments, and analyzing the results. The authors declare no competing financial interests. This work was also supported by a grant from the National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00001. Funding: This work was supported by Hungarian Science Foundation Grant OTKA 109521 and National Research Development and Innovation Office GINOP-2.3.2-15-2016-00001. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

<span style="font-size:14.0pt;color:black;mso-bidi-font-weight:bold" lang="EN-IN">Enhanced secretion of azadirachtin by perrneabilized margosa <i>(Azadirachta indica) </i>cells </span>

89-91Role of permeabilizing agents on secretion of Azadirachtin from margosa callus cultures was investigated under laboratory conditions. The results indicated that most of the synthesised azadirachtin remains inside the cells. Different permeabilizers showed variation in secretion pattern. The most effective was found to be Triton X-100, which secreted 10 mg/l at 150 ppm level followed by DMSO and chitosan. This is the first report of its nature on pemeabilizing agent induced enhanced secretion of azadirachtin from nuem callus cultures

Enhanced production of antimicrobial sesquiterpenes and lipoxygenase metabolites in elicitor-treated hairy root cultures of Solanum tuberosum

Potato (Solanum tuberosum) hairy root cultures, established by infecting potato tuber discs with Agrobacterium rhizogenes, were used as a model system for the production of antimicrobial sesquiterpenes and lipoxygenase (LOX) metabolites. Of the four sesquiterpene phytoalexins (rishitin, lubimin, phytuberin and phytuberol) detected in elicitor-treated hairy root cultures, rishitin (213 µg g<SUP>−1</SUP> dry wt) was the most predominant followed by lubimin (171 µg g<SUP>−1</SUP> dry wt). The elicitors also induced LOX activity (25-fold increase) and LOX metabolites, mainly 9-hydroxyoctadecadienoic acid and 9-hydroxyoctadecatrienoic acid, in potato hairy root cultures. The combination of fungal elicitor plus cyclodextrin was the most effective elicitor treatment, followed by methyl jasmonate plus cyclodextrin in inducing sesquiterpenes and LOX metabolites

Sex Differences in Cardiovascular Disease and Cognitive Dysfunction in Rural West Elderly Texans

BACKGROUND: The prevalence of cognitive dysfunction increases in elderly due to cardiovascular disease related risk factors in rural communities like West Texas. OBJECTIVE: The purpose of this study was to find risk factors of cardiovascular disease (CVD) related to cognitive dysfunction and their impact on elderly adults in rural West Texans. METHODS: Statistical methods such as Pearson\u27s chi-squared and a multinomial logistic regression were utilized to analyze data. We used SPSS software to detect and understand the nature of the risk factors. RESULTS: A summary of statistics was obtained by using Pearson\u27s chi-squared test for categorical variables. CVD, diabetes mellitus, and depression were significantly associated with cognitive dysfunction for both males and females ( = 0.0001), whereas anxiety was found to be significantly associated with cognitive dysfunction for females ( = 0.0001). Age group and race/ethnicity were significantly associated with cognitive dysfunction for both males and females ( = 0.0001). By performing a multinomial logistic regression method and controlling for confounders, the significant risk factors ( \u3c  0.05)- age (65- 84 years), diabetes, and memory loss for age-associated cognitive impairment; diabetes for cognitive impairment no dementia; age (65- 84, ≥85 years), CVD, diabetes, depression, memory loss, non-Hispanic Whites, and Black/African-Americans for mild cognitive impairment; and age, memory loss, non-Hispanic Whites, Black/African-Americans, and male gender were found for dementia. CONCLUSION: CVD related risk factors in developing cognitive dysfunction exist and integrating such risk variables may guide relevant policy interventions to reduce Alzheimer\u27s incidence or dementia in rural communities in West Texans