Comparison of architect assay and elecsys HBs Ag II assay in the quantification of hepatitis B surface antigen in chronic HBV patients

Background. Hepatitis B virus (HBV) infection is a global health concern, with an estimated 296 million chronic carriers worldwide. Quantification of hepatitis B surface antigen (HBsAg) is a crucial tool in HBV disease management, providing valuable insights into disease progression and treatment efficacy. Objective. To evaluate the comparative performance of the Abbott Architect HBsAg QT and Roche Elecsys HBsAg II assays in quantifying hepatitis B surface antigen (HBsAg) levels in patients with chronic hepatitis B (CHB). Methods. This prospective study enrolled 60 confirmed CHB patients between February 2021 and November 2021. HBsAg levels were measured using both assays and subsequently log-transformed (log10 IU/mL) for statistical analysis. Interclass correlation coefficient (ICC), Pearson correlation coefficient, and Bland-Altman analyses were employed to assess assay concordance and systematic bias. Results. A statistically significant positive correlation was observed between the Elecsys HBsAg II and Architect HBsAg QT assays for both untreated and treatment-receiving CHB patients (ICC values not specified, p <0.001). Notably, Architect consistently yielded higher HBsAg measurements compared to Elecsys. Conclusion. Both the Elecsys HBsAg II and Architect HBsAg QT assays demonstrate robust correlation in quantifying HBsAg levels in CHB patients. However, the Architect assay exhibits a systematic positive bias relative to Elecsys, which should be considered when interpreting results and making clinical decisions. Both tools provide reliable assessments for HBsAg quantification within CHB management strategies, but it is essential to be aware of potential assay-specific differences

Amalgam Attribute Based Encryption Scheme over the Cloud Data for Secure Access in the Hybrid Cloud

Abstract In the emergence of cloud computing, data owners are aggravated to outsource their complex data management system from local site to commercial cloud for great flexibility and economic saving. But for protecting data privacy, sensitive data has to be encrypted before outsourcing to commercial public cloud. Encrypted cloud data search system remains a very challenging task because of inherent security and privacy obstacles. There are so many security issues over the hybrid cloud during migration of data from one site to public cloud and also we cannot handle group of receivers in case of SKE. For secure communication and also handle dynamic attributes with continuous values, we need a new technique called as Amalgam attribute based encryption techniques. It is amalgam, as it combines the cipher text -policy attribute-based encryption (CP-ABE) with location-based encryption (LBE) on the level of symmetric keys in the hybrid cloud