A Hybrid Quantum Encoding Algorithm of Vector Quantization for Image Compression

Many classical encoding algorithms of Vector Quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N). A pure quantum VQ encoding algorithm with probability of success near 100% has been proposed, that performs operations 45sqrt(N) times approximately. In this paper, a hybrid quantum VQ encoding algorithm between classical method and quantum algorithm is presented. The number of its operations is less than sqrt(N) for most images, and it is more efficient than the pure quantum algorithm. Key Words: Vector Quantization, Grover's Algorithm, Image Compression, Quantum AlgorithmComment: Modify on June 21. 10pages, 3 figure

Pairing and Isospin Symmetry in Proton-Rich Nuclei

Unlike their lighter counterparts, most odd-odd N=Z nuclei with mass A > 40 40 have ground states with isospin T=1, suggesting an increased role for the isovector pairing interaction. A simple SO(5) seniority-like model of this interaction reveals a striking and heretofore unnoticed interplay between like-particle and neutron-proton isovector pairing near N=Z that is reflected in the number of each kind of pair as a function of A and T. Large scale shell-model calculations exhibit the same trends, despite the simultaneous presence of isoscalar pairs, deformation, and other correlations.Comment: 8 pages + 2 postscript figures, in RevTeX. Discussion of isospin projection in HFB added. This version to appear in Phys. Lett.

Tailoring of motional states in double-well potentials by time-dependent processes

We show that the vibrational state tailoring method developed for molecular systems can be applied for cold atoms in optical lattices. The original method is based on a three-level model interacting with two strong laser pulses in a counterintuitive sequence [M. Rodriguez et al., Phys. Rev. A 62, 053413 (2000)]. Here we outline the conditions for achieving similar dynamics with single time-dependent potential surfaces. It is shown that guided switching between diabatic and adiabatic evolution has an essential role in this system. We also show that efficient and precise tailoring of motional states in optical lattices can be achieved, for instance, simply by superimposing two lattices and moving them with respect to each other.Comment: 9 pages, 11 figures, 25 references; accepted to PRA; v2: minor explanatory remarks added & typos correcte

Does exercise improve glycaemic control in type 1 diabetes? A systematic review and meta-analysis.

This is the final published version. Available from PLoS via the DOI in this record.OBJECTIVE: Whilst regular exercise is advocated for people with type 1 diabetes, the benefits of this therapy are poorly delineated. Our objective was to review the evidence for a glycaemic benefit of exercise in type 1 diabetes. RESEARCH DESIGN AND METHODS: Electronic database searches were carried out in MEDLINE, Embase, Cochrane's Controlled Trials Register and SPORTDiscus. In addition, we searched for as yet unpublished but completed trials. Glycaemic benefit was defined as an improvement in glycosylated haemoglobin (HbA1c). Both randomised and non-randomised controlled trials were included. RESULTS: Thirteen studies were identified in the systematic review. Meta-analysis of twelve of these (including 452 patients) demonstrated an HbA1c reduction but this was not statistically significant (standardised mean difference (SMD) -0.25; 95% CI, -0.59 to 0.09). CONCLUSIONS: This meta-analysis does not reveal evidence for a glycaemic benefit of exercise as measured by HbA1c. Reasons for this finding could include increased calorie intake, insulin dose reductions around the time of exercise or lack of power. We also suggest that HbA1c may not be a sensitive indicator of glycaemic control, and that improvement in glycaemic variability may not be reflected in this measure. Exercise does however have other proven benefits in type 1 diabetes, and remains an important part of its management

A study of temperature-related non-linearity at the metal-silicon interface

In this paper, we investigate the temperature dependencies of metal-semiconductor interfaces in an effort to better reproduce the current-voltage-temperature (IVT) characteristics of any Schottky diode, regardless of homogeneity. Four silicon Schottky diodes were fabricated for this work, each displaying different degrees of inhomogeneity; a relatively homogeneous NiV/Si diode, a Ti/Si and Cr/Si diode with double bumps at only the lowest temperatures, and a Nb/Si diode displaying extensive non-linearity. The 77–300 K IVT responses are modelled using a semi-automated implementation of Tung's electron transport model, and each of the diodes are well reproduced. However, in achieving this, it is revealed that each of the three key fitting parameters within the model display a significant temperature dependency. In analysing these dependencies, we reveal how a rise in thermal energy “activates” exponentially more interfacial patches, the activation rate being dependent on the carrier concentration at the patch saddle point (the patch's maximum barrier height), which in turn is linked to the relative homogeneity of each diode. Finally, in a review of Tung's model, problems in the divergence of the current paths at low temperature are explained to be inherent due to the simplification of an interface that will contain competing defects and inhomogeneities

Preference of Small Molecules for Local Minimum Conformations when Binding to Proteins

It is well known that small molecules (ligands) do not necessarily adopt their lowest potential energy conformations when binding to proteins. Analyses of protein-bound ligand crystal structures have reportedly shown that many of them do not even adopt the conformations at local minima of their potential energy surfaces (local minimum conformations). The results of these analyses raise a concern regarding the validity of virtual screening methods that use ligands in local minimum conformations. Here we report a normal-mode-analysis (NMA) study of 100 crystal structures of protein-bound ligands. Our data show that the energy minimization of a ligand alone does not automatically stop at a local minimum conformation if the minimum of the potential energy surface is shallow, thus leading to the folding of the ligand. Furthermore, our data show that all 100 ligand conformations in their protein-bound ligand crystal structures are nearly identical to their local minimum conformations obtained from NMA-monitored energy minimization, suggesting that ligands prefer to adopt local minimum conformations when binding to proteins. These results both support virtual screening methods that use ligands in local minimum conformations and caution about possible adverse effect of excessive energy minimization when generating a database of ligand conformations for virtual screening

Normal-Mode-Analysis–Monitored Energy Minimization Procedure for Generating Small–Molecule Bound Conformations

The energy minimization of a small molecule alone does not automatically stop at a local minimum of the potential energy surface of the molecule if the minimum is shallow, thus leading to folding of the molecule and consequently hampering the generation of the bound conformation of a guest in the absence of its host. This questions the practicality of virtual screening methods that use conformations at local minima of their potential energy surfaces (local minimum conformations) as potential bound conformations. Here we report a normal-mode-analysis–monitored energy minimization (NEM) procedure that generates local minimum conformations as potential bound conformations. Of 22 selected guest–host complex crystal structures with guest structures possessing up to four rotatable bonds, all complexes were reproduced, with guest mass–weighted root mean square deviations of <1.0 Å, through docking with the NEM–generated guest local minimum conformations. An analysis of the potential energies of these local minimum conformations showed that 22 (100%), 18 (82%), 16 (73%), and 12 (55%) of the 22 guest bound conformations in the crystal structures had conformational strain energies of less than or equal to 3.8, 2.0, 0.6, and 0.0 kcal/mol, respectively. These results suggest that (1) the NEM procedure can generate small–molecule bound conformations, and (2) guests adopt low-strain–energy conformations for complexation, thus supporting the virtual screening methods that use local minimum conformations

Modally selective nonlinear ultrasonic waves for characterization of pitting damage in whipple shields of spacecraft

Featuring hundreds of craters, cracks and diverse microscopic defects disorderedly scattered over a wide region, the pitting damage in a typical Whipple shield of spacecraft induces highly complex wave scattering. Due to the dispersive and multimode natures, only nonlinear ultrasonic waves (NUWs) with exact phase-velocity matching condition are generally used to evaluate the microstructural material deterioration. Targeting accurate, holistic evaluation of pitting damage, semi-analytical finite element (SAFE) approach is adopted to identify the internal resonant conditions and to select an efficient mode pair for characterizing pitting damage. To explore the feasibility of pitting damage evaluation by using the selected mode pair and fully utilize its unique merits, the cumulative effect of second harmonics is analyzed using numerical simulations and corroborated by experiment. Regardless of the selection of mode pair (i.e., S1-s2 and S0-s0), the amplitude of second harmonics obtained in the pitted plate is observed to increase significantly after the probing GUWs traverse the pitted region, upon interacting with the pitting damage. This phenomenon is remarkable particularly when the probing GUW does not satisfy the requirement of internal resonance. The mode pairs S0-s0 with different degrees of phase-velocity mismatching are further analyzed. Results show that the hypervelocity impact-induced pitting damage in the rear wall of Whipple shields can be detected accurately using the mode pair S0-s0, and a relatively higher excitation frequency is preferred due to its higher degree of phase-velocity mismatching, leading to standing out of the pitting damage-induced CAN