176 research outputs found
Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice
To study the role of peripheral blood leukocytes (PBL) in the pathogenesis of human systemic lupus erythematosus (SLE), we transferred PBL from 5 SLE patients into 15 severe combined immunodeficiency (SCID) mice. Such reconstituted mice showed long-term presence of auto-antibodies characteristic of the donor in their sera, as well as human immunoglobulin deposition, and in some cases mouse C3, in the renal glomeruli. SCID mice repopulated with PBLs from normal donors do not develop serologic abnormalities or immunodeposits. It is concluded that human SLE serology and some associated renal changes can be reproduced solely by PBL transferred from afflicted patients, and that SCID-human-SLE mice may serve as an in vivo laboratory model for the study of human SLE
Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.
Deciphering the peptide iodination code: Influence on subsequent gas-phase radical generation with photodissociation ESI-MS
The role of lymphocytes in antibody formation I. Restoration of the haemolysin response in X -irradiated rats with lymphocytes from normal and immunologically tolerant donors
Increased spontaneous polyclonal activation of b lymphocytes in mice with spontaneous autoimmune disease.
Circulating gp70-anti-gp70 complexes and their role in the pathogenesis of murine systemic lupus erythematosus. Abstr.
Immunopathogenicity and oncogencity of murine leukaemia virus. IV. Antinuclear antibody response and tumour induction in b10.a Recombinant mice.
Association of retroviral gp70 immune complexes with glomeruloneph- ritis in f2 generation of nzb x nzw mice. Abstr.
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