161 research outputs found
Systems biology of platelet-vessel wall interactions
Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies
Central Bank Intervention, Sterilization and Monetary Independence: The Case of Pakistan
Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations
Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Due to the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs in order to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability; (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation; (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse; and (4) post-marketing epidemiological studies
Effects of Social Reinforcement, Subject Sex, and Experimenter Sex on Children'S Motor Performance
Kinetics of Switchable Proton Escape from a Proton-Wire within Green Fluorescence Protein
SLEEP CYCLES AND SKIN POTENTIAL IN NEWBORNS STUDIED WITH A SIMPLIFIED OBSERVATION AND RECORDING SYSTEM
NMDA-Receptor Activity Visualized with (S)-[N-Methyl-11C]Ketamine and Positron Emission Tomography in Patients with Medial Temporal Lobe Epilepsy
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