The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count

The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count. Time from seroconversion to clinical AIDS was the main outcome measure. Rates of CD4 decline were estimated using the ordinary least squares regression method. AIDS incidences were compared in individuals who had previously experienced either a steeper or a less steep rate of CD4 decline. Cox proportional hazards model including a time-dependent covariate for the rate of CD4 decline was performed. The rate of prior CD4 decline was significantly associated with the risk of developing AIDS independently from the most recent CD4 count, with a 2 % increase in hazard of AIDS (P < 0.01) for a difference of 10 cells/mm(3) in the estimated yearly drop in CD4 count. This finding gives scientific credit to the belief that individuals with a prior steeper CD4 decline consistently have a higher subsequent risk of developing AIDS than those with a less steep prior decline

Nucleon-nucleon cross sections in neutron-rich matter and isospin transport in heavy-ion reactions at intermediate energies

Nucleon-nucleon (NN) cross sections are evaluated in neutron-rich matter using a scaling model according to nucleon effective masses. It is found that the in-medium NN cross sections are not only reduced but also have a different isospin dependence compared with the free-space ones. Because of the neutron-proton effective mass splitting the difference between nn and pp scattering cross sections increases with the increasing isospin asymmetry of the medium. Within the transport model IBUU04, the in-medium NN cross sections are found to influence significantly the isospin transport in heavy-ion reactions. With the in-medium NN cross sections, a symmetry energy of $E_{sym}(\rho)\approx 31.6(\rho /\rho_{0})^{0.69}$ was found most acceptable compared with both the MSU isospin diffusion data and the presently acceptable neutron-skin thickness in $^{208}$Pb. The isospin dependent part $K_{asy}(\rho _{0})$ of isobaric nuclear incompressibility was further narrowed down to $-500\pm 50$ MeV. The possibility of determining simultaneously the in-medium NN cross sections and the symmetry energy was also studied. The proton transverse flow, or even better the combined transverse flow of neutrons and protons, can be used as a probe of the in-medium NN cross sections without much hindrance from the uncertainties of the symmetry energy.Comment: 32 pages including 14 figures. Submitted to Phys. Rev.

Distribution and conservation of Oncilla (Leopardus tigrinus) of Yungas, Argentina

En la Argentina y las Yungas, el Tirica es el felino con rango de distribución más restringido y probablemente localmente raro. En este trabajo se presenta un mapa de prioridades de conservación para el Tirica (Leopardus tigrinus) que se desarrolló en base a un mapa de distribución potencial y un mapa de uso de la tierra. Para al mapa de distribución se desarrolló un modelo de distribución de la especie usando el programa MaxEnt y 64 puntos de presencia actual de la Argentina (Yungas y Bosque Atlántico). Se midió el rendimiento general del mapa con el AUC o área bajo la curva ROC, que fue de 0.996; lo que indica un buen rendimiento. Se superpuso este mapa con un mapa de uso de la tierra humano para excluir áreas no aptas para la especie. El mapa resultante indica que ya se ha perdido casi la mitad (48%) del hábitat potencial para la especie, en particular en el borde oriental de su distribución y en el sur donde probablemente la especie nunca estuvo presente. Dos aras son importantes para la conectividad del hábitat y por la alta probabilidad de presencia y por lo tanto, para la conservación de Tirica. Se espera que este mapa sea de utilidad para conservacionistas y tomadores de decisiones.In Argentina and Yungas, Oncilla is the felid species with the smallest distribution range and probably locally rare. Based on the potential distribution map and human land use we present a map indicating important areas for Oncilla conservation. Therefore we developed a potential distribution map for Oncilla (Leopardus tigrinus) using MaxEnt and 64 existing presence points of Argentina (Yungas and Atlantic Forest). We measured the general performance of the map using the AUC or area under the Roc curve, which was 0.996, indicating a model with a good general performance. We superimposed this map with a map of human land use to exclude areas not suitable for the species. The resulting map indicates that already almost half (48%) of potential habitat for the species is lost, particularly in the eastern limit of its distribution and in the south, where the species probably was never present. Two areas are important for habitat connectivity or high presence probability and therefore, conservation of Oncilla. This map is hopefully useful for conservation actions and decision makers.Fil: Cuyckens, Griet An Erica. Universidad Nacional de Jujuy. Facultad de Ciencias Agrarias. Centro de Estudios Ambientales Territoriales y Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perovic, P. G.. Administracion de Parques Nacionales; Argentin

Random Surfing Without Teleportation

In the standard Random Surfer Model, the teleportation matrix is necessary to ensure that the final PageRank vector is well-defined. The introduction of this matrix, however, results in serious problems and imposes fundamental limitations to the quality of the ranking vectors. In this work, building on the recently proposed NCDawareRank framework, we exploit the decomposition of the underlying space into blocks, and we derive easy to check necessary and sufficient conditions for random surfing without teleportation.Comment: 13 pages. Published in the Volume: "Algorithms, Probability, Networks and Games, Springer-Verlag, 2015". (The updated version corrects small typos/errors

Intruder level and deformation in the SD-pair shell model

The influence of the intruder level on nuclear deformation is studied within the framework of the nucleon-pair shell model truncated to an SD-pair subspace. The results suggest that the intruder level has a tendency to soften the deformation and plays an important role in determining the onset of rotational behavior.Comment: 2 input TeX files, 2 figures, submitted to Phys. Lett.

Who Contributes to the Knowledge Sharing Economy?

Information sharing dynamics of social networks rely on a small set of influencers to effectively reach a large audience. Our recent results and observations demonstrate that the shape and identity of this elite, especially those contributing \emph{original} content, is difficult to predict. Information acquisition is often cited as an example of a public good. However, this emerging and powerful theory has yet to provably offer qualitative insights on how specialization of users into active and passive participants occurs. This paper bridges, for the first time, the theory of public goods and the analysis of diffusion in social media. We introduce a non-linear model of \emph{perishable} public goods, leveraging new observations about sharing of media sources. The primary contribution of this work is to show that \emph{shelf time}, which characterizes the rate at which content get renewed, is a critical factor in audience participation. Our model proves a fundamental \emph{dichotomy} in information diffusion: While short-lived content has simple and predictable diffusion, long-lived content has complex specialization. This occurs even when all information seekers are \emph{ex ante} identical and could be a contributing factor to the difficulty of predicting social network participation and evolution.Comment: 15 pages in ACM Conference on Online Social Networks 201

Electronic and optical properties of LiBC

LiBC, a semiconducting ternary borocarbide constituted of the lightest elements only, has been synthesized and characterized by x-ray powder diffraction, dielectric spectroscopy, and conductivity measurements. Utilizing an infrared microscope the phonon spectrum has been investigated in single crystals. The in-plane B-C stretching mode has been detected at 150 meV, noticeably higher than in AlB2, a non-superconducting isostructural analog of MgB2. It is this stretching mode, which reveals a strong electron-phonon coupling in MgB2, driving it into a superconducting state below 40 K, and is believed to mediate predicted high-temperature superconductivity in hole-doped LiBC [H. Rosner, A. Kitaigorodsky, and W. E. Pickett, Phys. Rev. Lett. 88, 127001 (2002)].Comment: 4 pages, 4 figure

Probing the isospin dependence of the in-medium nucleon-nucleon cross sections with radioactive beams

Within a transport model we search for potential probes of the isospin dependence of the in-medium nucleon-nucleon (NN) cross sections. Traditional measures of the nuclear stopping power are found sensitive to the magnitude but they are ambiguous for determining the isospin dependence of the in-medium NN cross sections. It is shown that isospin tracers, such as the neutron/proton ratio of free nucleons, at backward rapidities/angles in nuclear reactions induced by radioactive beams in inverse kinematics is a sensitive probe of the isospin dependence of the in-medium NN cross sections. At forward rapidities/angles, on the other hand, they are more sensitive to the density dependence of the symmetry energy. Measurements of the rapidity/angular dependence of the isospin transport in nuclear reactions will enable a better understanding of the isospin dependence of in-medium nuclear effective interactions.Comment: 19 pages including 7 figures, submitted to Phys. Rev.

Imprints of the nuclear symmetry energy on gravitational waves from the axial w-modes of neutron stars

The eigen-frequencies of the axial w-modes of oscillating neutron stars are studied using the continued fraction method with an Equation of State (EOS) partially constrained by the recent terrestrial nuclear laboratory data. It is shown that the density dependence of the nuclear symmetry energy $E_{sym}(\rho)$ affects significantly both the frequencies and the damping times of these modes. Besides confirming the previously found universal behavior of the mass-scaled eigen-frequencies as functions of the compactness of neutron stars, we explored several alternative universal scaling functions. Moreover, the $w_{II}$-mode is found to exist only for neutron stars having a compactness of $M/R\geq 0.1078$ independent of the EOS used.Comment: Version appeared in Phys. Rev. C80, 025801 (2009