2,4-Dimethyl-N-(4-methyl­phen­yl)benzene­sulfonamide

The asymmetric unit of the crystal of the title compound, C15H17NO2S, contains two independent mol­ecules, which are twisted at the S—N bonds with C—SO2—NH—C torsion angles of 48.3 (2) (mol­ecule 1) and −75.7 (3)° (mol­ecule 2). The dihedral angles between the benzene rings are 72.0 (1) (mol­ecule 1) and 78.3 (1)° (mol­ecule 2). The crystal structure features inversion dimers linked by pairs of N—H⋯O hydrogen bonds

N-(3,5-Dichloro­phen­yl)-4-methyl­benzene­sulfonamide

In the crystal structure of the title compound, C13H11Cl2NO2S, the conformation of the N—C bond in the C—SO2—NH—C segment is gauche with respect to the SO bonds. The two benzene rings are tilted by 79.6 (1)° relative to each other. In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds occur

N-(3,4-Dichloro­phen­yl)-2,4-dimethyl­benzene­sulfonamide

In the crystal structure of the title compound, C14H13Cl2NO2S, the configurations of the N—C bond with respect to the S=O bonds are trans and gauche. The mol­ecule is bent at the S atom with a C—SO2—NH—C torsion angle of −69.7 (2)°. The conformation of the N—H bond is syn to the 3-chloro group in the substituted aniline ring. The two benzene rings are tilted with respect to each other by 82.4 (1)°. The presence of N—H⋯O(S) hydrogen bonding packs the mol­ecules into supra­molecular chains along the b axis

COMPARATIVE STUDY OF EFFICACY AND SAFETY OF AZITHROMYCIN ALONE AND IN COMBINATION WITH PROBIOTIC IN THE TREATMENT OF IMPETIGO IN CHILDREN

Objective: Impetigo is a superficial infection of the skin that involves only the epidermis. It affects mostly children, usually on exposed areas of the body (eg. The face and the legs). Staphylococcus aureus is the most important causative organism. Streptococcus pyogenes (i.e.) group A beta-hemolytic streptococcus) causes fewer cases, either alone or in combination with S. aureus. The objective of this study is to find out the efficacy and safety of azithromycin alone and in combination with probiotic among children suffering from impetigo.Methods: This prospective, randomized, single-blinded interventional study was conducted for a period of 6 mo in pediatric OPD and dermatology OPD in Rajah Muthiah Medical College and Hospital. A total of 100 patients, randomly divided into two groups with 50 patients in each group. Group, I patients treated with Azithromycin 10 mg/kg/d for 5 d. Group II patients treated with Azithromycin 10 mg/kg/d for 5 d with probiotic (50 million spores of Lactobacillus sporegens, Streptococcus faecalis 30 million spores, clostridium butyricum 2 million spores, Bacillus mesentericus 1 million spores) twice daily for 5ds.Results: Reduction in a number of lesions and wound area, clinical response were highly significant in Azithromycin with the probiotic-treated group.Conclusion: In this study, probiotic bacteria may counteract the inflammatory process beyond the intestinal milieu. The results of this study indicate that Azithromycin with probiotic is effective in the treatment of impetigo

Case report on laurence moon biedyl syndrome

Laurence moon Biedyl syndrome is a rare autosomal recessive condition with a wide spectrum of clinical features. The accepted major criteria for diagnosis include retinal dystrophy, obesity, Polydactyly, male hypogonadism, mental retardation and renal dysfunction. We have presented a 36 year old male patient exhibiting characteristic features of Laurence moon Biedyl syndrome and then the literature is reviewed

2,4-Dichloro-N-(2-chloro­phen­yl)benzene­sulfonamide

In the title compound, C12H8Cl3NO2S, the conformation of the N—H bond in the C—SO2—NH—C segment is syn to the ortho-Cl in the aniline ring. The dihedral angle between the two benzene rings is 74.3 (1)°. An intra­molecular N—H⋯Cl hydrogen bond occurs. In the crystal, pairs of N—H⋯O hydrogen bonds link the mol­ecules into dimers

2,4-Dichloro-N-(3-chloro­phen­yl)benzene­sulfonamide

In the title compound, C12H8Cl3NO2S, the conformation of the N—H bond in the C—SO2—NH—C segment is anti to the meta-Cl in the aniline ring. The mol­ecule is twisted at the S atom, the C—SO2—NH—C torsion angle being 62.3 (2)°. The dihedral angle between the two benzene rings is 69.3 (1)°. The crystal structure features inversion dimers linked by pairs of N—H⋯O hydrogen bonds

N-(3,5-Dichloro­phen­yl)-2,4-dimethyl­benzene­sulfonamide

In the crystal structure of the title compound, C14H13Cl2NO2S, the conformation of the N—C bond in the C—SO2—NH—C segment has gauche torsions with respect to the S=O bonds. The mol­ecule is bent at the N atom, with an C—SO2—NH—C torsion angle of −54.9 (3)°. The two benzene rings are tilted relative to each other by 82.3 (2)°. The mol­ecules are linked into centrosymmetric R 2 2(8) motifs by N—H⋯O hydrogen bonds and C—H⋯π inter­actions along [100]

2,2-Dimethyl-N-(phenyl­sulfon­yl)acetamide

In the title compound, C10H13NO3S, the N—H and C=O bonds in the SO2—NH—CO—C segment are anti to each other. The benzene ring and the SO2—NH—CO—C segment form a dihedral angle of 87.4 (1)°. The crystal packing features inversion-related dimers linked by pairs of N—H⋯O hydrogen bonds

N-(3,5-Dichloro­phen­yl)-4-methyl­benzene­sulfonamide

In the crystal structure of the title compound, C13H11Cl2NO2S, the conformation of the N—C bond in the C—SO2—NH—C segment is gauche with respect to the SO bonds. The two benzene rings are tilted by 79.6 (1)° relative to each other. In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds occur