Reducing the Bias of Causality Measures

Measures of the direction and strength of the interdependence between two time series are evaluated and modified in order to reduce the bias in the estimation of the measures, so that they give zero values when there is no causal effect. For this, point shuffling is employed as used in the frame of surrogate data. This correction is not specific to a particular measure and it is implemented here on measures based on state space reconstruction and information measures. The performance of the causality measures and their modifications is evaluated on simulated uncoupled and coupled dynamical systems and for different settings of embedding dimension, time series length and noise level. The corrected measures, and particularly the suggested corrected transfer entropy, turn out to stabilize at the zero level in the absence of causal effect and detect correctly the direction of information flow when it is present. The measures are also evaluated on electroencephalograms (EEG) for the detection of the information flow in the brain of an epileptic patient. The performance of the measures on EEG is interpreted, in view of the results from the simulation study.Comment: 30 pages, 12 figures, accepted to Physical Review

The Electrostatic Ion Beam Trap : a mass spectrometer of infinite mass range

We study the ions dynamics inside an Electrostatic Ion Beam Trap (EIBT) and show that the stability of the trapping is ruled by a Hill's equation. This unexpectedly demonstrates that an EIBT, in the reference frame of the ions works very similar to a quadrupole trap. The parallelism between these two kinds of traps is illustrated by comparing experimental and theoretical stability diagrams of the EIBT. The main difference with quadrupole traps is that the stability depends only on the ratio of the acceleration and trapping electrostatic potentials, not on the mass nor the charge of the ions. All kinds of ions can be trapped simultaneously and since parametric resonances are proportional to the square root of the charge/mass ratio the EIBT can be used as a mass spectrometer of infinite mass range

Parity independence of the zero-bias conductance peak in a nanowire based topological superconductor-quantum dot hybrid device

We explore the signatures of Majorana fermions in a nanowire based topological superconductor-quantum dot-topological superconductor hybrid device by charge transport measurements. The device is made from an epitaxially grown InSb nanowire with two superconductor Nb contacts on a Si/SiO$_2$ substrate. At low temperatures, a quantum dot is formed in the segment of the InSb nanowire between the two Nb contacts and the two Nb contacted segments of the InSb nanowire show superconductivity due to the proximity effect. At zero magnetic field, well defined Coulomb diamonds and the Kondo effect are observed in the charge stability diagram measurements in the Coulomb blockade regime of the quantum dot. Under the application of a finite, sufficiently strong magnetic field, a zero-bias conductance peak structure is observed in the same Coulomb blockade regime. It is found that the zero-bias conductance peak is present in many consecutive Coulomb diamonds, irrespective of the even-odd parity of the quasi-particle occupation number in the quantum dot. In addition, we find that the zero-bias conductance peak is in most cases accompanied by two differential conductance peaks, forming a triple-peak structure, and the separation between the two side peaks in bias voltage shows oscillations closely correlated to the background Coulomb conductance oscillations of the device. The observed zero-bias conductance peak and the associated triple-peak structure are in line with the signatures of Majorana fermion physics in a nanowire based topological superconductor-quantum dot-topological superconductor system, in which the two Majorana bound states adjacent to the quantum dot are hybridized into a pair of quasi-particle states with finite energies and the other two Majorana bound states remain as the zero-energy modes located at the two ends of the entire InSb nanowire.Comment: 6 pages, 4 figure

Six Years Observation After Successful Treatment of Bacterial Vaginosis

Objective: The cure rate after treatment of bacterial vaginosis (BV) differs in various investigations, but most studies report a cure rate of 70% after 1 month

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.

GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen. The LPL•GPIHBP1 complex is responsible for margination of triglyceride-rich lipoproteins along capillaries and their lipolytic processing. The current work conceptualizes a model for the GPIHBP1•LPL interaction based on biophysical measurements with hydrogen-deuterium exchange/mass spectrometry, surface plasmon resonance, and zero-length cross-linking. According to this model, GPIHBP1 comprises two functionally distinct domains: (1) an intrinsically disordered acidic N-terminal domain; and (2) a folded C-terminal domain that tethers GPIHBP1 to the cell membrane by glycosylphosphatidylinositol. We demonstrate that these domains serve different roles in regulating the kinetics of LPL binding. Importantly, the acidic domain stabilizes LPL catalytic activity by mitigating the global unfolding of LPL's catalytic domain. This study provides a conceptual framework for understanding intravascular lipolysis and GPIHBP1 and LPL mutations causing familial chylomicronemia

Testing for Multipartite Quantum Nonlocality Using Functional Bell Inequalities

We show that arbitrary functions of continuous variables, e.g. position and momentum, can be used to generate tests that distinguish quantum theory from local hidden variable theories. By optimising these functions, we obtain more robust violations of local causality than obtained previously. We analytically calculate the optimal function and include the effect of nonideal detectors and noise, revealing that optimized functional inequalities are resistant to standard forms of decoherence. These inequalities could allow a loophole-free Bell test with efficient homodyne detection