Natural Circulation in the ATUCHA-I PHWR Nuclear Power Plant

A systematic study of natural circulation (NC) in a postulated, varying primary mass inventory scenario at residual power fractions has been performed for a nuclear power plant operating in Argentina. It is a pressurized heavy water reactor, cooled and moderated by heavy water. The analysis seems particularly relevant at present, because a second nuclear power plant (NPP), of similar design and nearly 745 MWe, is now under finalization. NRC-RELAP5/MOD3.3 was the code used to perform the simulations. Results obtained are presented in the form of natural circulation flow maps. The trends obtained fit in the expected limits for integral test facilities representative of PWRs. In addition, the validity of a simplified analysis to scale single and two-phase core flow has been verified. A set of constants has been obtained, which permits predicting NC core mass flow rate (CMFR) for this NPP. Results are partially validated, for single-phase NC flow, using a documented plant transient, showing reasonable agreement. Also, the effect of pressurizer size on the predicted evolution curve in the NC flow map (NCFM) is discussed

Spatial entanglement and state engineering via four-photon Hong-Ou-Mandel interference

The phenomenon of entanglement is the basis of quantum information and quantum communication processes. Entangled systems with a large number of photons are of great interest at present because they provide a platform for streaming technologies based on photonics. In this paper we present a device which operates with four-photons and based on the Hong-Ou-Mandel (HOM) interference. The presented device allows to maximize the degree of spatial entanglement and generate the highly entangled four-dimensional Bell states. Furthermore, the use of the interferometer in different regimes leads to fast interference fringes in the coincidence probability with period of oscillations twice smaller than the pump wavelength. We have a good agreement between theoretical simulations and experimental results.Comment: 20 pages, 7 figur

In vivo silencing of genes coding for dTip60 chromatin remodeling complex subunits affects polytene chromosome organization and proper development in Drosophila melanogaster

Chromatin organization is developmentally regulated by epigenetic changes mediated by histone‐modifying enzymes and chromatin remodeling complexes. In Drosophila melanogaster, the Tip60 chromatin remodeling complex (dTip60) play roles in chromatin regulation, which are shared by evolutionarily‐related complexes identified in animal and plants. Recently, it was found that most subunits previously assigned to the dTip60 complex are shared by two related complexes, DOM‐A.C and DOM‐B.C, defined by DOM‐A and DOM‐B isoforms, respectively. In this work, we combined classical genetics, cell biology, and reverse genetics approaches to further investigate the biological roles played during Drosophila melanogaster development by a number of subunits originally assigned to the dTip60 complex

Redesign of a Large Lecture Course Into a Small-Group Learning Course

Objective. To describe the redesign of a large self-care course previously delivered in a traditional lecture format to a small-group case-based course

Primary open angle glaucoma: an overview on medical therapy

The purpose of this review is to discuss the topics relevant to the use of intraocular pressure-lowering strategies, which remains the first line in the management of glaucoma. Estimates of blindness from glaucoma and identification of risk factors remain of interest for all ophthalmologists. New functional tests offer promise for better detection and more accurate diagnosis of glaucoma. We finally discuss the impact of various glaucoma therapies, the principles of monotherapy and fixed combinations, which offer benefits of convenience, cost, and safety

Academic Pharmacy: Where is Our Influence?

Objective. To evaluate the talents of fellows from cohorts 1-10 of the Academic Leadership Fellows Program (ALFP)