1,082 research outputs found
Thermo-optic noise in coated mirrors for high-precision optical measurements
Thermal fluctuations in the coatings used to make high-reflectors are
becoming significant noise sources in precision optical measurements and are
particularly relevant to advanced gravitational wave detectors. There are two
recognized sources of coating thermal noise, mechanical loss and thermal
dissipation. Thermal dissipation causes thermal fluctuations in the coating
which produce noise via the thermo-elastic and thermo-refractive mechanisms. We
treat these mechanisms coherently, give a correction for finite coating
thickness, and evaluate the implications for Advanced LIGO
Inhaled nitric oxide for high-altitude pulmonary edema
BACKGROUND. Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. When administered by inhalation, nitric oxide, an endothelium-derived relaxing factor, attenuates the pulmonary vasoconstriction produced by short-term hypoxia. METHODS. We studied the effects of inhaled nitric oxide on pulmonary-artery pressure and arterial oxygenation in 18 mountaineers prone to high-altitude pulmonary edema and 18 mountaineers resistant to this condition in a high altitude laboratory (altitude, 4559 m). We also obtained lung-perfusion scans before and during nitric oxide inhalation to gain further insight into the mechanism of action of nitric oxide. RESULTS. In the high-altitude laboratory, subjects prone to high-altitude pulmonary edema had more pronounced pulmonary hypertension and hypoxemia than subjects resistant to high-altitude pulmonary edema. Arterial oxygen saturation was inversely related to the severity of pulmonary hypertension (r=-0.50, P=0.002). In subjects prone to high-altitude pulmonary edema, the inhalation of nitric oxide (40 ppm for 15 minutes) produced a decrease in mean (+/-SD) systolic pulmonary-artery pressure that was three times larger than the decrease in subjects resistant to such edema (25.9+/-8.9 vs. 8.7+/-4.8 mm Hg, P<0.001). Inhaled nitric oxide improved arterial oxygenation in the 10 subjects who had radiographic evidence of pulmonary edema (arterial oxygen saturation increased from 67+/-10 to 73+/-12 percent, P=0.047), whereas it worsened oxygenation in subjects resistant to high-altitude pulmonary edema. The nitric oxide-induced improvement in arterial oxygenation in subjects with high-altitude pulmonary edema was accompanied by a shift in blood flow in the lung away from edematous segments and toward nonedematous segments. CONCLUSIONS. The inhalation of nitric oxide improves arterial oxygenation in high-altitude pulmonary edema, and this beneficial effect may be related to its favorable action on the distribution of blood flow in the lungs. A defect in nitric nitric oxide synthesis may contribute to high-altitude pulmonary edema
Patient-reported outcome measures obtained via E-Health tools ease the assessment burden and encourage patient participation in cancer care (PaCC Study)
Patient-reported outcome measures obtained via E-Health tools ease the assessment burden and encourage patient participation in cancer care (PaCC Study) BACKGROUND: E-health based patient-reported outcome measures (PROMs) have the potential to automate early identification of both nutrition status and distress status in cancer patients while facilitating treatment and encouraging patient participation. This cross-sectional study assessed the acceptability, accuracy, and clinical utility of PROMs collected via E-Health tools among patients undergoing treatment for stomach, colorectal, and pancreatic tumors. RESULTS: Eight-nine percent mostly, or completely, agreed that PROMs via tablets should be integrated in routine clinical care. Men were significantly more likely to require help completing the questionnaires than women (inv.OR= 0.51, 95% CI=(0.27, 0.95), p = 0.035). The level of help needed increased by 3% with each 1-year increase in age (inv. OR=1.03, 95% CI=(1.01, 1.06), p = 0.013). On average, a patient tended to declare weight which was 0.84 kg inferior to their true weight (Bland and Altman 95 % CI=(-3.9, 5.6); SD: 2.41) and a height which was 0.95 cm superior to their true height (Bland and Altman 95 % CI=(-5, 3.1); SD 2.08). Patient-reported nutrition status was significantly associated with the professionally generated assessment (95% CI=(2.27, 4.15), p < 0.001). As nutrition status declined, the distress score increased (95%CI=(0.88, 1.68), p < 0.001). Of the patients, 48.8% who were both distressed and malnourished requested supportive care to address their problems. CONCLUSION: Patient-reported assessments utilizing E-health tools are an accurate and efficient method to encourage patient participation in cancer care while simultaneously ensuring that regular assessment of psycho-social and nutritional aspects of care are efficiently integrated in the daily clinical routine
Search for gravitational waves associated with the August 2006 timing glitch of the Vela pulsar
The physical mechanisms responsible for pulsar timing glitches are thought to excite quasinormal mode oscillations in their parent neutron star that couple to gravitational-wave emission. In August 2006, a timing glitch was observed in the radio emission of PSR B0833-45, the Vela pulsar. At the time of the glitch, the two colocated Hanford gravitational-wave detectors of the Laser Interferometer Gravitational wave observatory (LIGO) were operational and taking data as part of the fifth LIGO science run (S5). We present the first direct search for the gravitational-wave emission associated with oscillations of the fundamental quadrupole mode excited by a pulsar timing glitch. No gravitational-wave detection
candidate was found. We place Bayesian 90% confidence upper limits of 6.3 x 10^(-21) to 1.4 x 10^(-20) on the peak intrinsic strain amplitude of gravitational-wave ring-down signals, depending on which spherical harmonic mode is excited. The corresponding range of energy upper limits is 5.0 x 10^(-44) to 1.3 x 10^(-45) erg
Gravitational wave radiometry: Mapping a stochastic gravitational wave background
The problem of the detection and mapping of a stochastic gravitational wave
background (SGWB), either of cosmological or astrophysical origin, bears a
strong semblance to the analysis of CMB anisotropy and polarization. The basic
statistic we use is the cross-correlation between the data from a pair of
detectors. In order to `point' the pair of detectors at different locations one
must suitably delay the signal by the amount it takes for the gravitational
waves (GW) to travel to both detectors corresponding to a source direction.
Then the raw (observed) sky map of the SGWB is the signal convolved with a beam
response function that varies with location in the sky. We first present a
thorough analytic understanding of the structure of the beam response function
using an analytic approach employing the stationary phase approximation. The
true sky map is obtained by numerically deconvolving the beam function in the
integral (convolution) equation. We adopt the maximum likelihood framework to
estimate the true sky map that has been successfully used in the broadly
similar, well-studied CMB map making problem. We numerically implement and
demonstrate the method on simulated (unpolarized) SGWB for the radiometer
consisting of the LIGO pair of detectors at Hanford and Livingston. We include
`realistic' additive Gaussian noise in each data stream based on the LIGO-I
noise power spectral density. The extension of the method to multiple baselines
and polarized GWB is outlined. In the near future the network of GW detectors,
including the Advanced LIGO and Virgo detectors that will be sensitive to
sources within a thousand times larger spatial volume, could provide promising
data sets for GW radiometry.Comment: 24 pages, 19 figures, pdflatex. Matched version published in Phys.
Rev. D - minor change
Optimal strategies for gravitational wave stochastic background searches in pulsar timing data
A low frequency stochastic background of gravitational waves may be detected
by pulsar timing experiments in the next five to ten years. Using methods
developed to analyze interferometric gravitational wave data, in this paper we
lay out the optimal techniques to detect a background of gravitational waves
using a pulsar timing array. We show that for pulsar distances and
gravitational wave frequencies typical of pulsar timing experiments, neglecting
the effect of the metric perturbation at the pulsar does not result in a
significant deviation from optimality. We discuss methods for setting upper
limits using the optimal statistic, show how to construct skymaps using the
pulsar timing array, and consider several issues associated with realistic
analysis of pulsar timing data.Comment: 20 pages, 6 figures. Added figure with sky sensitivity for Parkes
Pulsar Timing Array, included dipole overlap reduction function and
derivation in appendix, extended likelihood discussio
Search for Gravitational-wave Inspiral Signals Associated with Short Gamma-ray Bursts During LIGO's Fifth and Virgo's First Science Run
Progenitor scenarios for short gamma-ray bursts (short GRBs) include coalescenses of two neutron stars or a neutron star and black hole, which would necessarily be accompanied by the emission of strong gravitational waves. We present a search for these known gravitational-wave signatures in temporal and directional coincidence with 22 GRBs that had sufficient gravitational-wave data available in multiple instruments during LIGO's fifth science run, S5, and Virgo's first science run, VSR1. We find no statistically significant gravitational-wave candidates within a [ – 5, + 1) s window around the trigger time of any GRB. Using the Wilcoxon-Mann-Whitney U-test, we find no evidence for an excess of weak gravitational-wave signals in our sample of GRBs. We exclude neutron star-black hole progenitors to a median 90% confidence exclusion distance of 6.7 Mpc
First search for gravitational waves from the youngest known neutron star
We present a search for periodic gravitational waves from the neutron star in the supernova remnant Cassiopeia
A. The search coherently analyzes data in a 12 day interval taken from the fifth science run of the Laser
Interferometer Gravitational-Wave Observatory. It searches gravitational-wave frequencies from 100 to 300 Hz
and covers a wide range of first and second frequency derivatives appropriate for the age of the remnant and
for different spin-down mechanisms. No gravitational-wave signal was detected. Within the range of search
frequencies, we set 95% confidence upper limits of (0.7–1.2) × 10^(−24) on the intrinsic gravitational-wave
strain, (0.4–4) × 10^(−4) on the equatorial ellipticity of the neutron star, and 0.005–0.14 on the amplitude of
r-mode oscillations of the neutron star. These direct upper limits beat indirect limits derived from energy
conservation and enter the range of theoretical predictions involving crystalline exotic matter or runaway r-modes.
This paper is also the first gravitational-wave search to present upper limits on the r-mode amplitude
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