3 research outputs found
Ab Initio Structural Energetics of Beta-Si3N4 Surfaces
Motivated by recent electron microscopy studies on the Si3N4/rare-earth oxide
interfaces, the atomic and electronic structures of bare beta-Si3N4 surfaces
are investigated from first principles. The equilibrium shape of a Si3N4
crystal is found to have a hexagonal cross section and a faceted dome-like base
in agreement with experimental observations. The large atomic relaxations on
the prismatic planes are driven by the tendency of Si to saturate its dangling
bonds, which gives rise to resonant-bond configurations or planar sp^2-type
bonding. We predict three bare surfaces with lower energies than the open-ring
(10-10) surface observed at the interface, which indicate that
non-stoichiometry and the presence of the rare-earth oxide play crucial roles
in determining the termination of the Si3N4 matrix grains.Comment: 4 Pages, 4 Figures, 1 tabl
Risk profile analysis and complications after surgery for autoimmune thyroid disease
Background: Surgical approaches to autoimmune thyroid disease are currently hampered by concerns over postoperative complications. Risk profiles and incidences of postoperative complications have not been investigated systematically, and studies with sufficient power to show valid data have not been performed. Methods: A prospective multicentre European study was conducted between July 2010 and December 2012. Questionnaires were used to collect data prospectively on patients who had surgery for autoimmune thyroid disease and the findings were compared with those of patients undergoing surgery for multinodular goitre. Logistic regression analysis was used to evaluate risk factors for thyroid surgery-specific complications, transient and permanent recurrent laryngeal nerve (RLN) palsy and hypoparathyroidism. Results: Data were available for 22 011 patients, of whom 18 955 were eligible for analysis (2488 who had surgery for autoimmune thyroid disease and 16 467 for multinodular goitre). Surgery for multinodular goitre and that for autoimmune thyroid disease did not differ significantly with regard to general complications. With regard to thyroid surgery-specific complications, the rate of temporary and permanent vocal cord palsy ranged from 2·7 to 6·7 per cent (P = 0·623) and from 0·0 to 1·4 per cent (P = 0·600) respectively, whereas the range for temporary and permanent hypoparathyroidism was 12·9 to 20·0 per cent (P < 0·001) and 0·0 to 7·0 per cent (P < 0·001) respectively. In logistic regression analysis of transient and permanent vocal cord palsy, autoimmune thyroid disease was not an independent risk factor. Autoimmune thyroid disease, extent of thyroid resection, number of identified parathyroid glands and no autotransplantation were identified as independent risk factors for both transient and permanent hypoparathyroidism. Conclusion: Surgery for autoimmune thyroid disease is safe in comparison with surgery for multinodular goitre in terms of general complications and RLN palsy. To avoid the increased risk of postoperative hypoparathyroidism, special attention needs to be paid to the parathyroid glands. © 2018 BJS Society Ltd Published by John Wiley & Sons LtdStiftelserna Wilhelm och Martina Lundgren