Atividade da redutase do nitrato e acúmulo de prolina livre em genótipos de soja transgênica (BRS-RR) sob deficiência hídrica.

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Avaliação de cultivares de soja transgênica (BRS-RR) em sistema precoce de semeadura (SPS).

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Rendimento de grãos de soja: efeito do espaçamento e da densidade.

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Avaliação das cultivares BRS Estância RR, BRS Tordilha RR e duas linhagens de soja em Sistema Tardio de Semeadura (STS).

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Avaliação das cultivares BRS Estância RR, BRS Tordilha RR e duas linhagens de soja em Sistema Precoce de Semeadura (SPS).

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Avaliação de cultivares de soja transgênica (BRS-RR) em sistema tardio de semeadura (STS).

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Avaliação das cultivares BRS Estância RR, BRS Tordilha RR e duas linhagens de soja em espaçamentos largos de Semeadura.

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Antibiotic Prescribing Patterns in Paediatric Primary Care in Italy: Findings from 2012–2018

Comprehensive data are needed to monitor antibiotic prescribing and inform stewardship. We aimed to evaluate the current antibiotic prescribing patterns, including treatment switching and prolongation, in the paediatric primary care setting in Italy. This database study assessed antibiotic prescriptions retrieved from Pedianet, a paediatric primary care database, from 1 January 2012 to 31 December 2018. Descriptive analyses were stratified by diagnosis class, calendar year, and children’s age. Generalized linear Poisson regression was used to assess variation in the prescriptions. In total, 505,927 antibiotic prescriptions were included. From 2012 to 2018, the number of antibiotics per child decreased significantly by 4% yearly from 0.79 in 2012 to 0.62 in 2018. Amoxicillin prescriptions decreased with increasing children’s age, while macrolides and third-generation cephalosporins had the opposite trend. Prescriptions were associated with a diagnosis of upper respiratory infection in 23% of cases, followed by pharyngitis (21%), bronchitis and bronchiolitis (12%), and acute otitis media (12%). Eight percent of treatment episodes were prolonged or switched class, mostly represented by co-amoxiclav, macrolides, and third-generation cephalosporins. Our findings report an overall decrease in antibiotic prescriptions, but pre-schoolers are still receiving more than one antibiotic yearly, and broad-spectrum antibiotics prescription rates remain the highest

Genetic linkage mapping applied to the generation of tools for breeding purposes and genetic dissection of grapevine agronomical traits at Embrapa Uva e Vinho.

Resumo

Treatment for Severe Malaria: Post-Artesunate Delayed Haemolysis and Neutropenia.

Parenteral artesunate (AS) is the WHO first-line treatment recommended in adults and children for severe malaria. Post-artesunate delayed haemolysis (PADH) is an uncommon adverse reaction to AS with a mechanism that is not fully understood, occurring in adults and children. Neutropenia is another possible finding after AS treatment, albeit rare. We present the case of a child who experienced both effects after treatment with AS for imported severe Falciparum malaria with very high parasitaemia. In addition, thirty-five paediatric cases of PADH, five cases of delayed anaemia without known haemolysis, and fourteen cases of neutropenia after artesunate treatment were identified from the literature review. PADH seems to be a dose-independent reaction and is not strongly related to hyperparasitaemia, although it is more frequent in this case. To date, the benefits of AS outweigh its potential side effects. However, haematological follow-up is mandatory to avoid possible complications from anaemia and neutropenia, especially in children treated with other contemporary drugs