162 research outputs found
Monitoring of Precipitation Hardening in an HSLA Steel Through EMAT Measurements of Magnetostriction
This work demonstrates a novel application of ultrasound: measurement of magnetostriction, the change of length of a ferromagnetic material that accompanies a change in magnetization. The technique involves measuring ultrasonic waves generated by an electromagnetic acoustic transducer (EMAT), and it offers an alternative method of measuring magnetostriction in cases where it would not be feasible to use strain gages (for example, on fragile, thin films)
Resuscitation Endpoints in Traumatic Shock: A Focused Review with Emphasis on Point-of-Care Approaches
Trauma resuscitation is a blend of art and science, with the traumatologist at the helm of a large, multidisciplinary team, making split-second decisions and overseeing various parallel processes. Despite tremendous progress over the past few decades, the “art” component continues to play a large part in the overall trauma resuscitation process, with the “science” part slowly but steadily increasing its footprint as a determinant of processes and decisions. Thus, it becomes critical for all clinicians to be able to recognize the evidence-based factors which can be most valuable in guiding trauma resuscitations. This chapter serves as an overview of the current clinical findings, resuscitative endpoints, imaging techniques, and physiologic indices that are most helpful in order to promptly recognize and treat traumatic shock as well as projecting forward to look at novel techniques and biomarkers. Though a single universal marker that accurately and consistently identifies traumatic shock has yet to be discovered, certain factors discussed, such as lactate and base deficit, have been proven to be much more reliable than others
Noise Probe of the Dynamic Phase Separation in La2/3Ca1/3MnO3
Giant Random Telegraph Noise (RTN) in the resistance fluctuation of a
macroscopic film of perovskite-type manganese oxide La2/3Ca1/3MnO3 has been
observed at various temperatures ranging from 4K to 170K, well below the Curie
temperature (TC = 210K). The amplitudes of the two-level-fluctuations (TLF)
vary from 0.01% to 0.2%. We use a statistical analysis of the life-times of the
TLF to gain insight into the microscopic electronic and magnetic state of this
manganite. At low temperature (below 30K) The TLF is well described by a
thermally activated two-level model. An estimate of the energy difference
between the two states is inferred. At higher temperature (between 60K and
170K) we observed critical effects of the temperature on the life-times of the
TLF. We discuss this peculiar temperature dependence in terms of a sharp change
in the free energy functional of the fluctuators. We attribute the origin of
the RTN to be a dynamic mixed-phase percolative conduction process, where
manganese clusters switch back and forth between two phases that differ in
their conductivity and magnetization.Comment: 15 pages, PDF only, Phys. Rev. Lett. (in press
Sliding charge density wave in manganites
The so-called stripe phase of the manganites is an important example of the
complex behaviour of metal oxides, and has long been interpreted as the
localisation of charge at atomic sites. Here, we demonstrate via resistance
measurements on La_{0.50}Ca_{0.50}MnO_3 that this state is in fact a
prototypical charge density wave (CDW) which undergoes collective transport.
Dramatic resistance hysteresis effects and broadband noise properties are
observed, both of which are typical of sliding CDW systems. Moreover, the high
levels of disorder typical of manganites result in behaviour similar to that of
well-known disordered CDW materials. Our discovery that the manganite
superstructure is a CDW shows that unusual transport and structural properties
do not require exotic physics, but can emerge when a well-understood phase (the
CDW) coexists with disorder.Comment: 13 pages; 4 figure
Low frequency 1/f noise in doped manganite grain-boundary junctions
We have performed a systematic analysis of the low frequency 1/f-noise in
single grain boundary junctions in the colossal magnetoresistance material
La_{2/3}Ca_{1/3}MnO_{3-delta}. The grain boundary junctions were formed in
epitaxial La_{2/3}Ca_{1/3}MnO_{3-delta} films deposited on SrTiO_3 bicrystal
substrates and show a large tunneling magnetoresistance of up to 300% at 4.2 K
as well as ideal, rectangular shaped resistance versus applied magnetic field
curves. Below the Curie temperature T_C the measured 1/f noise is dominated by
the grain boundary. The dependence of the noise on bias current, temperature
and applied magnetic field gives clear evidence that the large amount of low
frequency noise is caused by localized sites with fluctuating magnetic moments
in a heavily disordered grain boundary region. At 4.2 K additional temporally
unstable Lorentzian components show up in the noise spectra that are most
likely caused by fluctuating clusters of interacting magnetic moments. Noise
due to fluctuating domains in the junction electrodes is found to play no
significant role.Comment: 9 pages, 7 figure
Violation of the fluctuation-dissipation theorem in glassy systems: basic notions and the numerical evidence
This review reports on the research done during the past years on violations
of the fluctuation-dissipation theorem (FDT) in glassy systems. It is focused
on the existence of a quasi-fluctuation-dissipation theorem (QFDT) in glassy
systems and the currently supporting knowledge gained from numerical simulation
studies. It covers a broad range of non-stationary aging and stationary driven
systems such as structural-glasses, spin-glasses, coarsening systems,
ferromagnetic models at criticality, trap models, models with entropy barriers,
kinetically constrained models, sheared systems and granular media. The review
is divided into four main parts: 1) An introductory section explaining basic
notions related to the existence of the FDT in equilibrium and its possible
extension to the glassy regime (QFDT), 2) A description of the basic analytical
tools and results derived in the framework of some exactly solvable models, 3)
A detailed report of the current evidence in favour of the QFDT and 4) A brief
digression on the experimental evidence in its favour. This review is intended
for inexpert readers who want to learn about the basic notions and concepts
related to the existence of the QFDT as well as for the more expert readers who
may be interested in more specific results.Comment: 120 pages, 37 figures. Topical review paper . Several typos and
misprints corrected, new references included and others updated. to be
published in J. Phys. A (Math. Gen.
GADD34 keeps the mTOR pathway inactivated in endoplasmic reticulum stress related autophagy
The balance of protein synthesis and proteolysis (i.e. proteostasis) is maintained by a complex regulatory network in which mTOR (mechanistic target of rapamycin serine/threonine kinase) pathway and unfolded protein response are prominent positive and negative actors. The interplay between the two systems has been revealed; however the mechanistic details of this crosstalk are largely unknown. The aim of the present study was to investigate the elements of crosstalk during endoplasmic reticulum stress and to verify the key role of GADD34 in the connection with the mTOR pathway. Here, we demonstrate that a transient activation of autophagy is present in endoplasmic reticulum stress provoked by thapsigargin or tunicamycin, which is turned into apoptotic cell death. The transient phase can be characterized by the elevation of the autophagic marker LC3II/I, by mTOR inactivation, AMP-activated protein kinase activation and increased GADD34 level. The switch from autophagy to apoptosis is accompanied with the appearance of apoptotic markers, mTOR reactivation, AMP-activated protein kinase inactivation and a decrease in GADD34. Inhibition of autophagy by 3-methyladenine shortens the transient phase, while inhibition of mTOR by rapamycin or resveratrol prolongs it. Inhibition of GADD34 by guanabenz or transfection of the cells with siGADD34 results in down-regulation of autophagy-dependent survival and a quick activation of mTOR, followed by apoptotic cell death. The negative effect of GADD34 inhibition is diminished when guanabenz or siGADD34 treatment is combined with rapamycin or resveratrol addition. These data confirm that GADD34 constitutes a mechanistic link between endoplasmic reticulum stress and mTOR inactivation, therefore promotes cell survival during endoplasmic reticulum stress. © 2016 Holczer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data
BACKGROUND: Chromosomal abnormalities have been associated with most human malignancies, with gains and losses on some genomic regions associated with particular entities. METHODS: Of the 15429 cases collected for the Progenetix molecular-cytogenetic database, 5918 malignant epithelial neoplasias analyzed by chromosomal Comparative Genomic Hybridization (CGH) were selected for further evaluation. For the 22 clinico-pathological entities with more than 50 cases, summary profiles for genomic imbalances were generated from case specific data and analyzed. RESULTS: With large variation in overall genomic instability, recurring genomic gains and losses were prominent. Most entities showed frequent gains involving 8q2, while gains on 20q, 1q, 3q, 5p, 7q and 17q were frequent in different entities. Loss "hot spots" included 3p, 4q, 13q, 17p and 18q among others. Related average imbalance patterns were found for clinically distinct entities, e.g. hepatocellular carcinomas (ca.) and ductal breast ca., as well as for histologically related entities (squamous cell ca. of different sites). CONCLUSION: Although considerable case-by-case variation of genomic profiles can be found by CGH in epithelial malignancies, a limited set of variously combined chromosomal imbalances may be typical for carcinogenesis. Focus on the respective regions should aid in target gene detection and pathway deduction
Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer
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