Cerebrospinal fluid P-tau(181P):biomarker for improved differential dementia diagnosis

The goal of this study is to investigate the value of tau phosphorylated at threonine 181 (P-tau(181p)) in the Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker panel for differential dementia diagnosis in autopsy confirmed AD and non-AD patients. The study population consisted of 140 autopsy confirmed AD and 77 autopsy confirmed non-AD dementia patients. CSF concentrations of amyloid-beta peptide of 42 amino acids (A(beta 1-42)), total tau protein (T-tau), and P-tau(181p) were determined with single analyte ELISA-kits (INNOTEST, Fujirebio, Ghent, Belgium). Diagnostic accuracy was assessed through receiver operating characteristic (ROC) curve analyses to obtain area under the curve (AUG) values and to define optimal cutoff values to discriminate AD from pooled and individual non-AD groups. ROC curve analyses were only performed on biomarkers and ratios that differed significantly between the groups. Pairwise comparison of AUG values was performed by means of DeLong tests. The A(beta 1-42)/P-tau(181p) ratio (AUG = 0.770) performed significantly better than A(beta 1-42) (AUG = 0.677, P = 0.004), T-tau (AUG = 0.592, P <0.001), and A beta(1-42)/T-tau (AUG = 0.678, P = 0.001), while Ptau(181p) (AUG = 0.720) performed significantly better than T-tau (AUG = 0.592, P <0.001) to discriminate between AD and the pooled non-AD group. When comparing AD and the individual non-AD diagnoses, A beta(1-42)/P-tau(181P) (AUG =0.894) discriminated AD from frontotemporal dementia significantly better than A(beta 1-42) (AUG = 0.776, P = 0.020) and T-tau (AUG = 0.746, P = 0.004), while P-tauisip/T-tau (AUG = 0.958) significantly improved the differentiation between AD and Creutzfeldt-Jakob disease as compared to A beta(1-42) (AUG = 0.688, P = 0.004), T-tau (AUG = 0.874, P = 0.040), and A beta(1-42)/P-tau(181P) (AUG = 0.760, P = 0.003). In conclusion, this study demonstrates P-tau(181P) P is an essential component of the AD CSF biomarker panel, and combined assessment of A beta(1-42), Ttau, and P-tau(181p) renders, to present date, the highest diagnostic power to discriminate between AD and non-AD dementias

Parity-even and Parity-odd Mesons in Covariant Light-front Approach

Decay constants and form factors for parity-even (s-wave) and parity-odd (p-wave) mesons are studied within a covariant light-front approach. The three universal Isgur-Wise functions for heavy-to-heavy meson transitions are obtained.Comment: 3 pages, talk given at the 2004 DPF Meeting, Riverside, CA. Aug 26-31, 200

Study of J/ψJ/\psi Production in sNN=200\sqrt{s_{NN}} = 200 GeV p+pp+p and d+Aud+Au Collisions in PHENIX

$J/\psi$ measurements in $p+p$ and $d+Au$ collisions serve as crucial references to understand the $J/\psi$ production in $Au+Au$ collisions at RHIC where quark gluon plasma (QGP) is expected to be formed. They also provide important clues to study various interesting phenomena such as the gluon shadowing and color glass condensate. We report the latest results from PHENIX experiment on $J/\psi$ production in $p+p$ and $d+Au$ collisions at forward, backward and midrapidity.Comment: 4pages, 6 figures, proceeding of the 18th International Conference on Nucleus-Nucleus Collisions (QM2005), Aug.4-9, Budapest, Hungar

Crystal Barrel Results on Two-Body Decays of the Scalar Glueball

The Crystal Barrel Collaboration observes scalar meson resonances in $\bar p p$ annihilation. Based on the measurements and partial wave analyses these are candidates for the $^3$P$_0$ groundstate nonet. The supernummerary $f_0(1500)$ resonance is identified as a scalar groundstate glueball. Important information for its characterization comes from the decay pattern into pseudoscalar and scalar mesons. Data on kaonic decays in the mass region up to 1700 MeV are now avaible at Crystal Barrel. New analysis results are presented.Comment: 5 pages, Latex, 3 eps figures, talk presented at EPS-HEP'97 conference in Jerusalem, Israel, 19-26 Aug. 199

Degeneracy and strategies of long baseline and reactor experiments

Assuming that the JPARC experiment measures the oscillation probabilities $P(\nu_\mu\to\nu_e)$ and $P(\bar{\nu}_\mu\to\bar{\nu}_e)$ at $|\Delta m^2_{31}|L/4E=\pi/2$, I discuss what kind of extra experiment (long baseline or reactor) can contribute to determination of $\theta_{13}$ and the CP phase $\delta$.Comment: 3 pages, 3 sets of figures, uses espcrc2.sty. Talk given at 6th International Workshop on Neutrino Factories and Superbeams (NuFact 04), Osaka, Japan, 26 Jul - 1 Aug 200

Phi_0 - Periodic Aharonov-Bohm Oscillations Survive Ensemble Averaging

We have demonstrated that Phi_0 periodic Aharonov--Bohm oscillations measured in a ensemble of rings may survive after ensemble averaging procedure. The central point is the difference between the preparation stage of the ensemble and the subsequent measurement stage. The robustness of the effect under finite temperature and non--zero charging energy of rings is discussed.Comment: 11 pages, 2 figures, RevTex 3.0,WIS-93/84/Aug.-P

System Size and Centrality Dependence of the Electric Charge Correlations in A+A and p+p Collisions at the SPS Energies

The Balance Function analysis method was developed in order to study the long range correlations in pseudo-rapidity of charged particle. The final results on p+p, C+C, Si+Si and centrality selected Pb+Pb collisions at $\sqrt{s_{NN}} = 17.2$ GeV and the preliminary data at $\sqrt{s_{NN}} = 8.8$ GeV are presented. The width of the Balance Function decreases with increasing system size and centrality of the collisions. This could suggest a delayed hadronization scenario.Comment: To appear in the proceedings of NPDC18, Prague, Czech Republic, 23-28 Aug. 200