Experience of Semantic-Cognitive Modeling of Religious Worldview in Languages of Different Structure (HARAM Concept)

The experience of reconstructing the religious (Islamic) concept as a value-cognitive and ideological constant is presented on the example of the concept HARAM/HIARAM in Russian and Avar linguistic cultures. The material for the study was data from lexicographic sources, paremiological funds of these languages, data from Russian and Avar texts (including translations) of spiritual literature; language data of the National Corpuses of the Russian and Avar languages. It is noted that the conceptual component of the concept under study reveals similarities in the compared linguocultures: the HARAM semantic model is represented by an obligatory component with a negative connotation 'everything that is bad, evil, sin > forbidden' [certain actions, deeds, objects and phenomena], and an optional component with a positive connotation: 'reserved place, forbidden [for everything bad] territory'. It is clarified that the value component of the concept is wider than in terms of an ordinary prohibition or taboo. It is shown that in the Muslim consciousness HARAM is a multicomponent concept with ambivalent semantics. Similarities and differences in the objectification of this concept may depend, first of all, on the specifics of the religious and linguistic consciousness of a person, his worldview; secondly, they can be conditioned by the discourse in which the concept is explicated, and hence the objectification takes place in different worldview (religious, everyday, etc.). The process of desacralization of the concept HARAM semantics is considered

Efficiency of treatment of laryngopharyngeal reflux with proton pump inhibitors depending on the <i>CYP2C19</i> polymorphism

Introduction. A treatment for LFR for many years, the superiority of PPIs over placebos is still controversial. Of particular clinical importance is the metabolic rate of PPIs in hepatocytes using the cytochrome P450 system with the participation of the isoenzyme CYP2C19 and partially CYP3A4Аim. We set a goal to study the efficacy of omeprazole 20 mg in the treatment of LFR symptoms without esophageal syndrome in patients with gastroesophageal reflux (GERD), depending on the polymorphism of the CYP2C19 genotype.Мaterials and мethods. After the exclusion criteria, 100 people took part in the study, 94 people completed the study.Results. According to the results, 26.6% of patients in the study group (residents of the Moscow region) with LFR symptoms without esophageal syndrome belong to fast metabolizers of CYP2C19, 4.2% to ultrafast metabolizers, 52.1% to normal metabolizers, 16% to intermediate metabolizers and 1.1% to slow CYP2C19.Conclusions. In patients with a rapid metabolism, within 1 month after discontinuation of omeprazole, it is necessary to increase the amount of omeprazole 20 mg intake up to 2 times a day in the morning and in the evening and reduce the duration of treatment to 6 weeks

Accounting of motivators and demotivators under introduction of the brc system

Рассматривается необходимость учета демотиваторов при работе с балльно-рейтинговой системой оцениванияThe article considers the need to take into account demotivators when working with the BRS syste

Check of knowleadge using score-rating system and independent test control

Анализируется проблема дублирования балльно-рейтинговой системы оценивания и независимого тестового контроля в системе подготовки специалистов. Предложены мероприятия по устранению недостатковIn article it is told about duplication of score-rating system and independent test controlin training system of specialists. Actions for elimination of shortcomingsare offere

State of cytokine system in ectopic pregnancy

In patients with recurrent ectopic pregnancy in comparison with primary ectopic pregnancy marked by an older age, high infection index, complicated by somatic, obstetrical and gynecological diseases, a higher rate of surgical interventions on the abdominal organs. Inclusion in the complex rehabilitation of local spa factors leads to an sighnificant decrease in the levels of proinflammatory and antiinflammatory cytokines, including IL-4 and TNF-a whit prevent further tissue destruction and proliferation of connective tissue in patients with recurrent and especially with primary ectopic pregnancy.У пациенток с повторной внематочной беременностью в сравнении с первичной отмечен более старший возраст, высокий инфекционный индекс, осложненный соматический, акушерский и гинекологический анамнез, большая частота оперативных вмешательств на органах брюшной полости. Включение в комплекс реабилитационных мероприятий местных бальнеологических факторов приводит к выраженному снижению уровней провоспалительных и противовоспалительных цитокинов, в том числе ИЛ-4 и ФНО-а, предотвращению дальнейшей тканевой деструкции и разрастанию соединительной ткани у пациенток с повторной и, особенно, с первичной внематочной беременностью

Features of the demographic situation in the Republic of Dagestan (2002-2012)

The subject of the study: demographic indicators in the Republic of Dagestan (RD) from 2002 to 2012. Topic of the research: dynamics and structure of the demographic data in RD and Russian Federation (RF). Objective: comprehensive analysis of the geographical features of RD, dynamics and structure of the demographic data in RD and RF from 2002 to 2012; detection features of demographic situation in RD in comparison to RF. Methodology: study of the indicators of the total population, its structure by age, sex, place of residence, including women and children; total death rate, birth rate, natality in the dynamics of RD in comparison to RF. Results: demographic situation in RD is characterized by high rate of natality due to the high level of growing birthrate, which is steady exceeding the index in RF more than 1,5 times while there is low index of death rate, that is progressively decreases and remains lower than in RF not less than 2,4 times; by increasing index of natality from 2005 to 2012, that reached level of 13,4 per 1000 population in 2012, this index is higher than in RF (0 per 1000); by a high proportion of rural population, that is higher than in RF more than 2 times (55,4% and 26% respectively); by high proportion of women of childbearing age (56,3% of the total female population), most of them live in the countryside (55%), by a high proportion of child population (0-14 years old), which is higher thatT in RF 1,6 times, that represents 24,9% and 15,5% respectively and with an equal index of working population proportion (62,2% and 36,2% respectively) indicates a high demographic and socio­economic burden on the working population in RD. Range of application of the results: when forming programs for optimizing the structure of health care in RD and in other subjects of RF; when forming territorial programs of Government guarantees of health care in RD and in other subjects of RF. Findings: integrated assessment of geographical features, transport connection, demographical situation features in the region, a detailed study of the reasons why the death rate of population is higher than average index in the RF, should be considered when planning structure and volume of medical care in the region.Предмет исследования: демографические показатели Республики Дагестан (РД) 2002-2012гг. Тема исследования: динамика и структура демографических показателей РД и Российской Федерации (РФ). Цель работы: анализ географических особенностей, динамики и структуры демографических показателей РД в период 2002-2012гг. в сравнении с РФ, выявление особенностей демографической ситуации в РД. Методология: изучение показателей общей численности населения РД, ее структуры по возрасту, полу, месту жительства, в т.ч. женского и детского; общей смертности населения, рождаемости, естественного прироста в динамике в сравнении с РФ. Результаты: демографическая ситуация в РД характеризуется: высоким темпом естественного прироста населения за счет высокого растущего уровня рождаемости, стабильно превышающего показатель в РФ более, чем в 1,5 раза на фоне низкого показателя общей смертности населения, который прогрессивно снижаясь, остается ниже, чем в РФ не менее, чем в 2,4 раза; увеличением показателя естественного прироста населения в 2005- 2012гг. на 58% с достижением в 2012г. уровня 13,4на 1000 населения, что выше, чем в РФ(0 на 1000 населения); высокой долей сельского населения, превышающей показатель в РФ более, чем в 2 раза (55,4% и 26% соответственно);высокой долей женщин детородного возраста (56,3 % от общей численности женского населения), большая часть которых проживает в сельской местности (55%);высокой долей детского населения (0-14 лет), превышающей показатель в РФ в 1,6 раза, что составляет 24,9% и 15,5% соответственно и при равном показателе доли трудоспособного населения (62,2% и63,2% соответственно), свидетельствует о высокой демографической и социально-экономической нагрузке на трудоспособное население РД. Область применения результатов: при формировании Программ оптимизации структуры оказания медицинской помощи в РД и других субъектах РФ; при формировании территориальных программ Государственных гарантий оказания медицинской помощи в РД и других субъектах РФ. Выводы: комплексная оценка географических особенностей, транспортного сообщения, особенностей демографической ситуации в регионе, детальное изучение причин, по которым показатели смертности населения превышают общероссийские показатели, необходимо учитывать при планировании структуры и объемов медицинской помощи в регионе

Twenty-year clinical progression of dysferlinopathy in patients from Dagestan

© 2017 Umakhanova, Bardakov, Mavlikeev, Chernova, Magomedova, Akhmedova, Yakovlev, Dalgatov, Fedotov, Isaev and Deev.To date, over 30 genes with mutations causing limb-girdle muscle dystrophy have been described. Dysferlinopathies are a form of limb-girdle muscle dystrophy type 2B with an incidence ranging from 1:1,300 to 1:200,000 in different populations. In 1996, Dr. S. N. Illarioshkin described a family from the Botlikhsky district of Dagestan, where limb-girdle muscle dystrophy type 2B and Miyoshi myopathy were diagnosed in 12 members from three generations of a large Avar family. In 2000, a previously undescribed mutation in the DYSF gene (c.TG573/574AT; p. Val67Asp) was detected in the affected members of this family. Twenty years later, in this work, we re-examine five known and seven newly affected family members previously diagnosed with dysferlinopathy. We observed disease progression in family members who were previously diagnosed and noted obvious clinical polymorphism of the disease. A typical clinical case is provided

Corrigendum: Twenty-year clinical progression of dysferlinopathy in patients from Dagestan [Front Neurol, 8, (2017) (77)] doi: 10.3389/fneur.2017.00077

The "Funding" section should be: This work was funded by Human Stem Cells Institute PJSC and Roman V. Deev. Theoretical part of this work was supported by Russian Scientific Foundation grant (14-15-00916). Ivan A. Yakovlev and Mikhail O. Mavlikeev were supported by the Russian Government Program of Competitive Growth of Kazan Federal University. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way

The role of lipoproteins in the bone metabolism in postmenopausal women against the background of obesity

The aim of this article was to study the effect of lipoproteins on bone mass in postmenopausal women against the background of obesity. The study included 165 women, who were postmenopausal. The 1st group included 87 women with abdominal obesity, the 2nd group - 78 women without obesity. In group 124 (27.8%) patients had normal values of bone mineral density, the osteopenia was defined in 48 (55.4%) patients and osteoporosis was defined in 15 (16.8%) patients. 2 It was noted that in the second group 22 (28.4%) patients had normal values of bone mineral density, 37 (47.7%) had osteopenia and 19 (23.9%) had osteoporosis. It can be assumed that the atherogenic changes in the lipid profile may be one of the risk factors in the formation of osteopenic syndrome in postmenopausal women against the background of obesity.Целью данного исследования явилось изучение влияния липопротеидов на костную массу женщин в постменопаузальном периоде на фоне ожирения. В исследование было включено 165 женщин в период постменопаузы. В 1-ю группу включены 87 женщин с абдоминальным типом ожирения, во 2-ю группу - 78 женщины без ожирения. В 1 группе 24 (27,8%) пациентки имели нормальные показатели минеральной плотности костной ткани, у 48 (55,4%) пациенток определялась остеопения и у 15 (16,8%) - остеолороз. Во 2 же группе отмечено, что у 22 (28,4%) пациентов имелись нормальные показатели минеральной плотности костной ткани, у 37 (47,7%) - остеопения и у 19 (23,9%) - остеопороз. Можно предположить, что атерогенные изменения в липидном профиле могут являться одним из факторов риска формирования остеоленического синдрома в постменопаузе на фоне ожирения