Crossover in the two-impurity Kondo model induced by direct charge tunneling

Quantum critical behavior in the two-impurity Kondo model requires the distinct separation of two scales, T_K >> T*, where T_K is the Kondo temperature and T* is the scale at which the system renormalizes away from the quantum critical point to a stable Fermi liquid fixed point. We provide a derivation of T* based on the renormalization group to lowest order. This result is confirmed by a numerical renormalization group (NRG) analysis which supplements the analytic derivation with additional quantitative precision. The form of the low-energy Fermi liquid fixed point is derived and subsequently confirmed by the NRG. We discuss implications for series double quantum dot systems.Comment: 10 pages, 6 figures; resubmitted Oct. 31, 2011 to include corrections discovered after original submissio

Reducing low frequency tonal noise in large ducts using a hybrid reactive-dissipative silencer

© 2017 Elsevier Ltd Noise generated by fans or turbines normally consists of a combination of narrow and broadband noise. To lower transmitted noise levels, it is attractive to use a combination of reactive and dissipative elements. However, this approach presents a number of challenges for larger systems. This is because reactive elements are commonly placed around the duct circumference where they are normally only effective up to the frequency at which the first higher order mode cuts on in the duct. For larger systems, this means that reactive elements work only in the low, and often very low, frequency range, whereas dissipative elements, which are distributed across the duct cross-section, generally work well in the medium to high frequency range. This can cause noise problems in the low to medium frequency range in larger systems. This article presents an alternative approach for delivering noise attenuation over the low to medium frequency range that is suitable for application in larger duct systems. This approach takes advantage of those splitter silencer designs commonly used in larger systems to integrate a reactive element into the splitter design. This delivers a hybrid splitter that uses a combination of dissipative and reactive elements so that the reactive element partitions the main airway. This has the advantage of introducing a quasi-planar transverse sound pressure field for each resonator in the low to medium frequency range, including frequencies above the first cut-on. It is demonstrated using predictions and measurements taken for a number of example silencers, that this approach enables reactive elements to work over an extended low to medium frequency range, including at frequencies above the first cut-on mode in the main duct. Accordingly, it is shown that a hybrid dissipative-reactive splitter design is capable of delivering improved levels of attenuation in the crucial low to medium frequency range

GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus

Background: The genetic background of atherosclerosis in type 2 diabetes mellitus (T2DM) is complex and poorly understood. Studying genetic components of intermediate phenotypes, such as endothelial dysfunction and oxidative stress, may aid in identifying novel genetic components for atherosclerosis in diabetic patients.<p></p> Methods: Five polymorphisms forming two haplotype blocks within the GTP cyclohydrolase 1 gene, encoding a rate limiting enzyme in tetrahydrobiopterin synthesis, were studied in the context of flow and nitroglycerin mediated dilation (FMD and NMD), intima-media thickness (IMT), and plasma concentrations of von Willebrand factor (vWF) and malondialdehyde (MDA).<p></p> Results: Rs841 was associated with FMD (p = 0.01), while polymorphisms Rs10483639, Rs841, Rs3783641 (which form a single haplotype) were associated with both MDA (p = 0.012, p = 0.0015 and p = 0.003, respectively) and vWF concentrations (p = 0.016, p = 0.03 and p = 0.045, respectively). In addition, polymorphism Rs8007267 was also associated with MDA (p = 0.006). Haplotype analysis confirmed the association of both haplotypes with studied variables.<p></p> Conclusions: Genetic variation of the GCH1 gene is associated with endothelial dysfunction and oxidative stress in T2DM patients

Scanning Electron Microscopy of High-Pressure-Frozen Sea Urchin Embryos

High-pressure-freezing permits direct cryo-fixation of sea urchin embryos having a defined developmental state without the formation of large ice crystals. We have investigated preparation protocols for observing high-pressure-frozen and freeze-fractured samples in the scanning electron microscope. High-pressure-freezing was superior to other freezing protocols, because the whole bulk sample was reasonably well frozen and the overall three-dimensional shape of the embryos was well preserved. The samples were either dehydrated by freeze-substitution and critical-point-drying, or imaged in the partially hydrated state, using a cold stage in the SEM. During freeze-substitution the samples were stabilized by fixatives. The disadvantage of this method was that shrinking and extraction effects, caused by the removal of the water, could not be avoided. These disadvantages were avoided when. the sample was imaged in the frozen-hydrated state using a cold-stage in the SEM. This would be the method of choice for morphometric studies. Frozen-hydrated samples, however, were very beam sensitive and many structures remained covered by the ice and were not visible. Frozen-hydrated samples were partially freeze-dried to make visible additional structures that had been covered by ice. However, this method also caused drying artifacts when too much water was removed

The linearization of the Kodama state

We study the question of whether the linearization of the Kodama state around classical deSitter spacetime is normalizable in the inner product of the theory of linearized gravitons on deSitter spacetime. We find the answer is no in the Lorentzian theory. However, in the Euclidean theory the corresponding linearized Kodama state is delta-functional normalizable. We discuss whether this result invalidates the conjecture that the full Kodama state is a good physical state for quantum gravity with positive cosmological constant.Comment: 14 pages, statement on the corresponding Yang-Mills case correcte

The Two Dimensional Kondo Model with Rashba Spin-Orbit Coupling

We investigate the effect that Rashba spin-orbit coupling has on the low energy behaviour of a two dimensional magnetic impurity system. It is shown that the Kondo effect, the screening of the magnetic impurity at temperatures T < T_K, is robust against such spin-orbit coupling, despite the fact that the spin of the conduction electrons is no longer a conserved quantity. A proposal is made for how the spin-orbit coupling may change the value of the Kondo temperature T_K in such systems and the prospects of measuring this change are discussed. We conclude that many of the assumptions made in our analysis invalidate our results as applied to recent experiments in semi-conductor quantum dots but may apply to measurements made with magnetic atoms placed on metallic surfaces.Comment: 22 pages, 1 figure; reference update

Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance

<p>Abstract</p> <p>Background</p> <p>High fat diet impairs nitric oxide (NO) bioavailability, and induces insulin resistance. The link between NO availability and the metabolic adaptation to a high fat diet is not well characterized. The purpose of this study was to investigate the effect of high fat diet on metabolism in mice with decreased (eNOS-/-) and increased (DDAH overexpressed) NO bioavailability.</p> <p>Methods</p> <p>eNOS-/- (n = 16), DDAH (n = 24), and WT (n = 19) mice were fed a high fat diet (HFD) for 13 weeks. Body weight, biochemical parameters, adipokines and insulin were monitored. The matrigel <it>in vivo </it>model with CD31 immunostaining was used to assess angiogenesis.</p> <p>Gene expression in adipose tissues was analyzed by microarray and Real Time PCR. Comparisons of the mean values were made using the unpaired Student t test and p < 0.05 were considered statistically significant.</p> <p>Results</p> <p>eNOS-/- mice gained less weight than control WT and DDAH mice. In DDAH mice, a greater increase in serum adiponectin and a lesser increment in glucose level was observed. Fasting insulin and cholesterol levels remained unchanged. The angiogenic response was increased in DDAH mice. In adipose tissue of DDAH mice, genes characteristic of differentiated adipocytes were down-regulated, whereas in eNOS-/- mice, genes associated with adipogenesis, fatty acid and triglyceride synthesis were upregulated.</p> <p>Conclusions</p> <p>Our results indicate that increased NO availability attenuates some HFD induced alterations in metabolism and gene expression associated with insulin resistance.</p