1,822 research outputs found
In search of performance effects of (in) direct industry science links.
Using patent data from the European Patent Office combined with firm level data, we evaluate the contribution of science linkages to the innovation performance of a firm at the patent level. We examine the effect of i) firm level linkages to science (firms active in publication and copublication), and ii) invention-specific linkages (patents with citations to scientific publications) on patent quality measures. Our results suggest that citations to scientific publications are not significant in explaining forward citations but are positively related to the scope of forward citations, both in terms of generality and geographical dispersion. Our main finding is that it is the linkage to science at the firm level that matters more for forward citations, except for patents in emerging technologies. In particular, non-science related patents of firms with firm level scientific linkages are more frequently and more quickly cited than comparable patents of firms without these science linkages.Citations; Data; Firm level data; Firms; Forward citation; Industrial innovation; Innovation; IT; Linkage; Patent; Patents; Performance; Publications; Quality; Research; Science; Technology; Value;
Molten-Salt Synthesized Pyrochlore Nanoparticles for Multifunctional Applications
There is a need in the scientific world to design and develop high quality nanomaterials with multifunctional applications. In this work, we explore the molten-salt method (MSS) as a new green method for the synthesis of complex metal oxides. We adjusted all synthesis parameters such as time, temperature and pH to generate an optimum La2Hf2O7 nanoparticle with a well define shape and surface. Activator ions such as Eu3+, Tb3+, Dy3+, Bi3+ and uranium ion (U4+, U6+) were used to monitor its structural and optical behavior effect when doped.
Our results showed effective quantum yield, thermal, pressure stability, near to white light color coordinate as determined by the International Commission on Illumination (CIE) with low color coordinate temperature (CCT) for white light emitting diode (WLEDs) applications. In addition, we explore the effectiveness of our material as a scintillator for radiation detection, bio-imaging and as a nuclear waste host. All results indicate that our host material shows potential as an efficient multifunctional nanomaterial for a wide range of applications
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A comparison of stage-specific all-cause mortality between testicular sex cord stromal tumors and germ cell tumors: results from the National Cancer Database.
BackgroundTesticular sex cord stromal tumors (SCSTs) are managed similarly to germ cell tumors (GCTs); however, few studies have directly compared outcomes between these tumor types. Using the National Cancer Database (NCDB), we sought to compare overall and stage-specific all-cause mortality (ACM) between SCSTs versus GCTs.MethodsNCDB was queried for patients diagnosed with SCSTs and GCTs between 2004 and 2013. Descriptive statistics were used to compare sociodemographic and clinical characteristics between groups. Univariable and multivariable Cox proportional hazards regression analyses were used to assess associations with ACM.ResultsWe identified 42,192 patients diagnosed with testicular cancer between 2004 and 2013, with 280 having SCSTs and 41,912 patients having GCTs. Median age for SCSTs and GCTs was 45 (interquartile range [IQR] 34-59) and 34 (IQR 27-43), respectively (p < 0.001). Median follow-up was 39 and 52 months, respectively. Overall, patients with SCSTs had greater risk of ACM compared to those with GCTs (HR 1.69, 95% CI 1.14-2.50). Private insurance, greater education, and fewer comorbidities were associated with reduced risk of ACM (p < 0.05 for all). Among those with stage I disease, tumor type was not associated with ACM on multivariable analysis. Among those with stage II/III disease, patients with SCSTs had increased risk of ACM compared to patients with GCTs (HR 3.29, 95% CI 1.89-5.72).ConclusionsPatients with advanced SCSTs had worse survival outcomes compared to those with advanced GCTs. These data suggest a need for further investigation to ascertain effective management recommendations for SCSTs
Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique.
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending the ART clinic in Kibera, Kenya, from April 2003 to December 2006 and in Mavalane, Mozambique, from December 2002 to March 2007. Data were collected on 5832 HIV-positive individuals who had initiated nevirapine- or efavirenz-based ART. Median baseline CD4+ count was 125 cells/μL (interquartile range [IQR] 55-196). Over a median follow-up time of 426 (IQR 147-693) days, 124 (2.4%) patients developed HT. Forty-one (54.7%) of 75 patients with grade 3 HT compared with 21 (80.8%) of 26 with grade 4 had associated clinical signs or symptoms (P = 0.018). Four (5.7%) of 124 patients with HT died in the first six months compared with 271 (5.3%) of 5159 patients who did not develop HT (P = 0.315). The proportion of patients developing HT was low and HT was not associated with increased mortality. Clinical signs and symptoms identified 50% of grade 3 HT and most cases of grade 4 HT. This suggests that in settings where alanine aminotransferase measurement is not feasible, nevirapine- and efavirenz-based ART may be given safely without laboratory monitoring
Hunting Galaxies to (and for) Extinction
In studies of star-forming regions, near-infrared excess (NIRX)
sources--objects with intrinsic colors redder than normal stars--constitute
both signal (young stars) and noise (e.g. background galaxies). We hunt down
(identify) galaxies using near-infrared observations in the Perseus
star-forming region by combining structural information, colors, and number
density estimates. Galaxies at moderate redshifts (z = 0.1 - 0.5) have colors
similar to young stellar objects (YSOs) at both near- and mid-infrared (e.g.
Spitzer) wavelengths, which limits our ability to identify YSOs from colors
alone. Structural information from high-quality near-infrared observations
allows us to better separate YSOs from galaxies, rejecting 2/5 of the YSO
candidates identified from Spitzer observations of our regions and potentially
extending the YSO luminosity function below K of 15 magnitudes where galaxy
contamination dominates. Once they are identified we use galaxies as valuable
extra signal for making extinction maps of molecular clouds. Our new iterative
procedure: the Galaxies Near Infrared Color Excess method Revisited (GNICER),
uses the mean colors of galaxies as a function of magnitude to include them in
extinction maps in an unbiased way. GNICER increases the number of background
sources used to probe the structure of a cloud, decreasing the noise and
increasing the resolution of extinction maps made far from the galactic plane.Comment: 16 pages and 16 figures. Accepted for publication in ApJ. Full
resolution version at
http://www.cfa.harvard.edu/COMPLETE/papers/Foster_HuntingGalaxies.pd
Rheology of distorted nematic liquid crystals
We use lattice Boltzmann simulations of the Beris--Edwards formulation of
nematodynamics to probe the response of a nematic liquid crystal with
conflicting anchoring at the boundaries under shear and Poiseuille flow. The
geometry we focus on is that of the hybrid aligned nematic (HAN) cell, common
in devices. In the nematic phase, backflow effects resulting from the elastic
distortion in the director field render the velocity profile strongly
non-Newtonian and asymmetric. As the transition to the isotropic phase is
approached, these effects become progressively weaker. If the fluid is heated
just above the transition point, however, another asymmetry appears, in the
dynamics of shear band formation.Comment: 7 pages, 4 figures. Accepted for publication in Europhys. Let
A FLAMINGOS Deep Near Infrared Imaging Survey of the Rosette Complex I: Identification and Distribution of the Embedded Population
We present the results of a deep near-infrared imaging survey of the Rosette
Complex. We studied the distribution of young embedded sources using a
variation of the Nearest Neighbor Method applied to a carefully selected sample
of near-infrared excess (NIRX) stars which trace the latest episode of star
formation in the complex. Our analysis confirmed the existence of seven
clusters previously detected in the molecular cloud, and identified four more
clusters across the complex. We determined that 60% of the young stars in the
complex and 86% of the stars within the molecular cloud are contained in
clusters, implying that the majority of stars in the Rosette formed in embedded
clusters. We compare the sizes, infrared excess fractions and average
extinction towards individual clusters to investigate their early evolution and
expansion. We found that the average infrared excess fraction of clusters
increases as a function of distance from NGC 2244, implying a temporal sequence
of star formation across the complex. This sequence appears to be primordial,
possibly resulting from the formation and evolution of the molecular cloud and
not from the interaction with the HII region.Comment: Accepted by Astrophysical Journa
Exploring the optical properties of La 2 Hf 2 O 7 :Pr 3+ nanoparticles under UV and X-ray excitation for potential lighting and scintillating applications
New optical materials with efficient luminescence and scintillation properties have drawn a great deal of attention due to the demand for optoelectronic devices and medical theranostics. Their nanomaterials are expected to reduce the cost while incrementing the efficiency for potential lighting and scintillator applications. In this study, we have developed praseodymium-doped lanthanum hafnate (La2Hf2O7:Pr3+) pyrochlore nanoparticles (NPs) using a combined co-precipitation and relatively low-temperature molten salt synthesis procedure. XRD and Raman investigations confirmed ordered pyrochlore phase for the as-synthesized undoped and Pr3+-doped La2Hf2O7 NPs. The emission profile displayed the involvement of both the 3P0 and 1D2 states in the photoluminescence process, however, the intensity of the emission from the 1D2 states was found to be higher than that from the 3P0 states. This can have a huge implication on the design of novel red phosphors for possible application in solid-state lighting. As a function of the Pr3+ concentration, we found that the 0.1%Pr3+ doped La2Hf2O7 NPs possessed the strongest emission intensity with a quantum yield of 20.54 ± 0.1%. The concentration quenching, in this case, is mainly induced by the cross-relaxation process 3P0 + 3H4 → 1D2 + 3H6. Emission kinetics studies showed that the fast decaying species arise because of the Pr3+ ions occupying the Hf4+ sites, whereas the slow decaying species can be attributed to the Pr3+ ions occupying the La3+ sites in the pyrochlore structure of La2Hf2O7. X-ray excited luminescence (XEL) showed a strong red-light emission, which showed that the material is a promising scintillator for radiation detection. In addition, the photon counts were found to be much higher when the NPs are exposed to X-rays when compared to ultraviolet light. Altogether, these La2Hf2O7:Pr3+ NPs have great potential as a good down-conversion phosphor as well as scintillator material
Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles
The development of feasible synthesis methods is critical for the successful exploration of novel properties and potential applications of nanomaterials. Here, we introduce the molten-salt synthesis (MSS) method for making metal oxide nanomaterials. Advantages over other methods include its simplicity, greenness, reliability, scalability, and generalizability. Using pyrochlore lanthanum hafnium oxide (La2Hf2O7) as a representative, we describe the MSS protocol for the successful synthesis of complex metal oxide nanoparticles (NPs). Furthermore, this method has the unique ability to produce NPs with different material features by changing various synthesis parameters such as pH, temperature, duration, and post-annealing. By fine-tuning these parameters, we are able to synthesize highly uniform, non-agglomerated, and highly crystalline NPs. As a specific example, we vary the particle size of the La2Hf2O7 NPs by changing the concentration of the ammonium hydroxide solution used in the MSS process, which allows us to further explore the effect of particle size on various properties. It is expected that the MSS method will become a more popular synthesis method for nanomaterials and more widely employed in the nanoscience and nanotechnology community in the upcoming years
Optimization of carbon and energy utilization through differential translational efficiency.
Control of translation is vital to all species. Here we employ a multi-omics approach to decipher condition-dependent translational regulation in the model acetogen Clostridium ljungdahlii. Integration of data from cells grown autotrophically or heterotrophically revealed that pathways critical to carbon and energy metabolism are under strong translational regulation. Major pathways involved in carbon and energy metabolism are not only differentially transcribed and translated, but their translational efficiencies are differentially elevated in response to resource availability under different growth conditions. We show that translational efficiency is not static and that it changes dynamically in response to mRNA expression levels. mRNAs harboring optimized 5'-untranslated region and coding region features, have higher translational efficiencies and are significantly enriched in genes encoding carbon and energy metabolism. In contrast, mRNAs enriched in housekeeping functions harbor sub-optimal features and have lower translational efficiencies. We propose that regulation of translational efficiency is crucial for effectively controlling resource allocation in energy-deprived microorganisms
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