18 research outputs found
Detection of methylation in the CpG islands of the p16INK4A, RASSF 1A and methylguanine methyltransferase gene promoters in pancreatic adenocarcinoma
Pancreatic cancer consists of an accumulation of genetic and epigenetic alterations. Recently, aberrant methylation of CpG islands of cancer-related genes has emerged as an important epigenetic mechanism of their transcriptional dysregulation during tumour development [1]. Therefore, new diagnostic methods, for early detection based on a better understanding of the molecular biology of pancreatic cancer, are required. We examined the methylation status of p16INK4A, RASSF 1A and methylguanine methyltransferase (MGMT) genes considered to be inactivated by promoter methylation in several tumours
The influence of bromocriptine on the ultrstructure of the biceps femoris muscle in mice
Bromocriptine and other dopaminergic
agonists drugs are used in Parkinson's disease.
In this paper we have studied the ultrastructure of
striated muscle of mice after bromocriptine treatment.
There was a tremendous increase in the number and
size of mitochondria. as well as a very notable increase in
the cristae. Some ultrastructure changes were also noted
at the neuromuscular junctions.
An explanation has been attempted in the light of
other investigations concerning the relationship of
microtubules and bromocriptine on the one hand, and
microtubules and mitochondria on the other