126 research outputs found
Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle
Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. In addition to increasing economic losses, the rise in bovine tuberculosis poses a human health risk. There is an urgent requirement for effective strategies for disease eradication; this will likely involve vaccination in conjunction with current test and slaughter policies. A policy involving vaccination would require an accurate diagnosis of M. bovis-infected animals and the potential to distinguish these animals from vaccinates. Currently used diagnostic tests, the skin test and gamma interferon (IFN-γ) blood test, have a sensitivity of up to 95%. A further complication is that M. bovis BCG-vaccinated animals are also scored positive by these tests. We tested the hypothesis that the quantification of IFN-γ-producing lymphocytes by flow cytometric analysis of intracellular IFN-γ expression would provide a more accurate discrimination of M. bovis-infected animals from BCG vaccinates. Significant numbers of IFN-γ-expressing CD4(+) T cells were detected following culture of heparinized blood from M. bovis-infected animals, but not from BCG vaccinates, with purified protein derived from M. bovis (PPD-B) or live mycobacteria. Only 1 of 17 BCG-vaccinated animals had a significant number of CD4(+) T lymphocytes expressing IFN-γ, compared with 21/22 M. bovis-infected animals. This assay could allow an accurate diagnosis of M. bovis and allow the discrimination of BCG-vaccinated cattle from infected cattle
Probing Cool and Warm Infrared Galaxies using Photometric and Structural Measures
We have analyzed a sample of nearby cool and warm infrared (IR) galaxies
using photometric and structural parameters. The set of measures include
far-infrared color (), total IR
luminosity (), radio surface brightness as well as radio,
near-infrared, and optical sizes. In a given luminosity range cool and warm
galaxies are considered as those sources that are found approximately below and above the mean color in the far-infrared
diagram. We find that galaxy radio surface brightness is well correlated with
color whereas size is less well correlated with color. Our analysis indicates
that IR galaxies that are dominated by cool dust are large, massive spirals
that are not strongly interacting or merging and presumably the ones with the
least active star formation. Dust in these cool objects is less centrally
concentrated than in the more typical luminous and ultra-luminous IR galaxies
that are dominated by warm dust. Our study also shows that low luminosity early
type unbarred and transitional spirals are responsible for the large scatter in
the diagram. Among highly luminous galaxies, late type unbarred
spirals are predominately warm, and early type unbarred and barred are
systematically cooler. We highlight the significance of diagram
in terms of local and high redshifts sub-millimeter galaxies.Comment: Accepted for publication in ApJ, 2006, 23 pages, 3 postscript
figures, 1 table. The table can be obtained on request from the author
The optically-powerful quasar E1821+643 is associated with a 300-kpc scale FRI radio structure
We present a deep image of the optically-powerful quasar E1821+643 at 18cm
made with the Very Large Array (VLA). This image reveals radio emission, over
280 kpc in extent, elongated way beyond the quasar's host galaxy. Its radio
structure has decreasing surface brightness with increasing distance from the
bright core, characteristic of FRI sources (Fanaroff & Riley 1974). Its radio
luminosity at 5GHz falls in the classification for `radio-quiet' quasars (it is
only 10^23.9 W/Hz/sr; see e.g. Kellermann et al 1994). Its radio luminosity at
151MHz (which is 10^25.3 W/Hz/sr) is at the transition luminosity observed to
separate FRIs and FRIIs. Hitherto, no optically-powerful quasar had been found
to have a conventional FRI radio structure. For searches at low-frequency this
is unsurprising given current sensitivity and plausible radio spectral indices
for radio-quiet quasars. We demonstrate the inevitability of the extent of any
FRqI radio structures being seriously under-estimated by existing targetted
follow-up observations of other optically-selected quasars, which are typically
short exposures of z > 0.3 objects, and discuss the implications for the
purported radio bimodality in quasars.
The nature of the inner arcsec-scale jet in E1821+643, together with its
large-scale radio structure, suggest that the jet-axis in this quasar is
precessing (cf. Galactic jet sources such as SS433). A possible explanation for
this is that its central engine is a binary whose black holes have yet to
coalesce. The ubiquity of precession in `radio-quiet' quasars, perhaps as a
means of reducing the observable radio luminosity expected in highly-accreting
systems, remains to be established.Comment: Accepted by ApJ Letters; higher quality versions of figures available
at http://www-astro.physics.ox.ac.uk/~km
Radio Variability of Radio Quiet and Radio Loud Quasars
The majority of quasars are weak in their radio emission, with flux densities
comparable to those in the optical, and energies far lower. A small fraction,
about 10%, are hundreds to thousands of times stronger in the radio.
Conventional wisdom holds that there are two classes of quasars, the radio
quiets and radio louds, with a deficit of sources having intermediate power.
Are there really two separate populations, and if so, is the physics of the
radio emission fundamentally different between them? This paper addresses the
second question, through a study of radio variability across the full range of
radio power, from quiet to loud. The basic findings are that the root mean
square amplitude of variability is independent of radio luminosity or
radio-to-optical flux density ratio, and that fractionally large variations can
occur on timescales of months or less in both radio quiet and radio loud
quasars. Combining this with similarities in other indicators, such as radio
spectral index and the presence of VLBI-scale components, leads to the
suggestion that the physics of radio emission in the inner regions of all
quasars is essentially the same, involving a compact, partially opaque core
together with a beamed jet.Comment: 32 pages, 9 figures. Astrophysical Journal, in pres
The Sunyaev-Zel'dovich Effect by Cocoons of Radio Galaxies
We estimate the deformation of the cosmic microwave background radiation by
the hot region (``cocoon'') around a radio galaxy. A simple model is adopted
for cocoon evolution while the jet is on, and a model of evolution is
constructed after the jet is off. It is found that at low redshift the phase
after the jet is off is longer than the lifetime of the jets. The Compton
y-parameter generated by cocoons is calculated with a Press-Schechter number
density evolution. The resultant value of y is of the same order as the COBE
constraint. The Sunyaev-Zeldovich effect due to cocoons could therefore be a
significant foreground source of small angular scale anisotropies in the cosmic
microwave background radiation.Comment: Published version, 23 pages with 5 figure
Interferometric Observations of the Nuclear Region of Arp220 at Submillimeter Wavelengths
We report the first submillimeter interferometric observations of an
ultraluminous infrared galaxy. We observed Arp220 in the CO J=3-2 line and
342GHz continuum with the single baseline CSO-JCMT interferometer consisting of
the Caltech Submillimeter Observatory (CSO) and the James Clerk Maxwell
Telescope (JCMT). Models were fit to the measured visibilities to constrain the
structure of the source. The morphologies of the CO J=3-2 line and 342GHz
continuum emission are similar to those seen in published maps at 230 and
110GHz. We clearly detect a binary source separated by about 1 arcsec in the
east-west direction in the 342GHz continuum. The CO J=3-2 visibility
amplitudes, however, indicate a more complicated structure, with evidence for a
compact binary at some velocities and rather more extended structure at others.
Less than 30% of the total CO J=3-2 emission is detected by the interferometer,
which implies the presence of significant quantities of extended gas. We also
obtained single-dish CO J=2-1, CO J=3-2 and HCN J=4-3 spectra. The HCN J=4-3
spectrum, unlike the CO spectra, is dominated by a single redshifted peak. The
HCN J=4-3/CO J=3-2, HCN J=4-3/HCN J=1-0 and CO J=3-2/2-1 line ratios are larger
in the redshifted (eastern) source, which suggests that the two sources may
have different physical conditions. This result might be explained by the
presence of an intense starburst that has begun to deplete or disperse the
densest gas in the western source, while the eastern source harbors undispersed
high density gas.Comment: 17 pages, 9 figures, 4 Tables. accepted by Ap
A relativistic jet in the radio-quiet quasar PG1407+263
We present the results of a multi-epoch radio monitoring campaign measuring
the milliarcsecond structure of the jet in the radio-quiet quasar PG1407+263.
This is the highest-sensitivity, highest-resolution multi-year study of a
distant active galaxy. The observations are naturally explained in terms of a
beamed relativistic jet, some of whose fluctuations in flux density can be
ascribed to interaction with the narrow-line region of the quasar. The optical
properties of PG1407+263, in particular the low equivalent widths of the
emission lines, may be related to the fact that we are viewing this quasar
almost pole-on, giving us a direct view into its broad-line region.Comment: 4 pages, uses emulateapj5.sty; accepted by ApJ Letter
Sensitive observations at 1.4 and 250 GHz of z > 5 QSOs
We present 1.4 and 5 GHz observations taken with the Very Large Array (VLA),
and observations at 250 GHz obtained with the Max-Planck millimeter bolometer
(MAMBO) at the IRAM 30~m telescope, of ten optically selected Quasi-stellar
Objects (QSOs) at 5.0 < z < 6.28. Four sources are detected at 1.4 GHz two of
which are radio loud and are also detected at 5 GHz. These results are roughly
consistent with there being no evolution of the radio-loud QSO fraction out to
z~6.
Three sources have been detected at 250 GHz or 350 GHz at much higher levels
than their 1.4 GHz flux densities suggesting that the observed mm emission is
likely thermal emission from warm dust, although more exotic possibilities
cannot be precluded.
The highest redshift source in our sample (J1030+0524 at z=6.28) is not
detected at 1.4 or 250 GHz, but four fairly bright radio sources (flux density
at 1.4GHz > 0.2 mJy) are detected in a 2' field centered on the QSO, including
an edge-brightened ('FRII') double radio source with an extent of about 1'.
A similar over-density of radio sources is seen in the field of the highest
redshift QSO J1148+5251. We speculate that these over-densities of radio
sources may indicate clusters along the lines-of-sight, in which case
gravitational lensing by the cluster could magnify the QSO emission by a factor
2 or so without giving rise to arcsecond-scale distortions in the optical
images of the QSOs.Comment: 25 pages, 12 figures. accepted by A
Rotating Nuclear Rings and Extreme Starbursts in Ultraluminous Galaxies
New high resolution interferometer data of 10 IR ultraluminous galaxies shows
the molecular gas is in rotating nuclear rings or disks with radii 300 to 800
pc. Most of the CO flux comes from a moderate-density, warm, intercloud medium
rather than self-gravitating clouds. Gas masses of ~ 5 x 10^9 Msun, 5 times
lower than the standard method are derived from a model of the molecular disks.
The ratio of molecular gas to dynamical mass, is M_gas/M_dyn ~ 1/6 with a
maximum ratio of gas to total mass surface density of 1/3. For the galaxies
VIIZw31, Arp193, and IRAS 10565+24, there is good evidence for rotating
molecular rings with a central gap. In addition to the rotating rings a new
class of star formation region is identified which we call an Extreme
Starburst. They have a characteristic size of only 100 pc., about 10^9 Msun of
gas and an IR luminosity of ~3 x 10^11 Lsun. Four extreme starbursts are
identified in the 3 closest galaxies in the sample Arp220, Arp193 and Mrk273.
They are the most prodigious star formation events in the local universe, each
representing about 1000 times as many OB stars as 30 Doradus. In Arp220, the CO
and 1.3 mm continuum maps show the two ``nuclei'' embedded in a central ring or
disk and a fainter structure extending 3 kpc to the east, normal to the nuclear
disk. There is no evidence that these sources really are the pre-merger nuclei.
They are compact, extreme starburst regions containing 10^9 Msun of dense
molecular gas and new stars, but no old stars. Most of the dust emission and
HCN emission arises in the two extreme starbursts. The entire bolometric
luminosity of Arp~220 comes from starbursts, not an AGN. In Mrk231, the disk
geometry shows that the molecular disk cannot be heated by the AGN; the far IR
luminosity of Mrk~231 is powered by a starburst, not the AGN. (Abridged)Comment: 97 pages Latex with aasms.sty, including 29 encapsulated Postscript
figures. Figs 18 and 23 are GIFs. 31 figures total. Text and higher quality
versions of figures available at
http://sbastk.ess.sunysb.edu/www/RINGS_ESB_PREPRINT.html To be published in
Ap. J., 10 Nov. 199
Production and characterization of two monoclonal antibodies to bovine tumour necrosis factor alpha (TNF-alpha.) and their cross-reactivity with ovine TNF-alpha
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