Efficacy of vitamin E and vitamin C against silica induced toxicity on male reproductive organs of albino rats

Silica is one of the most documented workplace contaminants. Long-term occupational exposure to silica is associated with an increased risk in respiratory diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease and lung cancer. The present study was carried out to observe the alteration in testosterone level & histopathological changes in the testis and epididymis after silica exposure, and to show whether therapeutic agents (Vitamin E + Vitamin C) used in study may provide recovery against exposure to silica. For investigations, silica was administered in albino rats as silicon dioxide at a dose of 40 mg/Kg for 28 days (IP) to produce toxic effects. Recovery pattern was evaluated by Vitamin E + vitamin C (50 mg/kg, ip + 100 mg/kg, po, for 5 days after silica administration. The study showed alterations in the various blood parameters after intraperitonealintoxication of silicon dioxide. Testosterone was significantly decreased in experimental rats after 28 days of silica intoxication. Therapeutic agents i.e. vitamin E and vitamin C recouped the values to normal control and recoupment was also observed in histology of testis and epididymis

Influence of silica intoxication on female reproductive organs with therapeutic agents vitamin E and vitamin C

The aim of the present study was to observe the alteration of blood biochemical and histopathological variables after silica exposure, and also to show whether therapeutic agents (Vitamin E + Vitamin C) used in study may provide recovery against exposure to silica. In this study, silica was administered as silicon dioxide at a dose of 40 mg/kg for 28 days to produce toxic effect. Recovery pattern was evaluated by Vitamin E + vitamin C (50 mg/kg, ip + 100 mg/kg, po), The present study showed alterations in the activities of oestrogen and LH were significantly decreased in experimental rats after 28 days of silica intoxication. The level of progesteron and FSH, were also decreased. Therapeutic agents i.e. vitamin E and vitamin C recouped the values to normal and near to control

Bulk Superconductivity in Bismuth-oxy-sulfide Bi4O4S3

Very recent report [1] on observation of superconductivity in Bi4O4S3 could potentially reignite the search for superconductivity in a broad range of layered sulphides. We report here synthesis of Bi4O4S3 at 5000C by vacuum encapsulation technique and basic characterizations. Detailed structural, magnetization, and electrical transport results are reported. Bi4O4S3 is contaminated by small amounts of Bi2S3 and Bi impurities. The majority phase is tetragonal I4/mmm space group with lattice parameters a = 3.9697(2){\AA}, c = 41.3520(1){\AA}. Both AC and DC magnetization measurements confirmed that Bi4O4S3 is a bulk superconductor with superconducting transition temperature (Tc) of 4.4K. Isothermal magnetization (MH) measurements indicated closed loops with clear signatures of flux pinning and irreversible behavior. The lower critical field (Hc1) at 2K, of the new superconductor is found to be ~39 Oe. The magneto-transport R(T, H) measurements showed a resistive broadening and decrease in Tc (R=0) to lower temperatures with increasing magnetic field. The extrapolated upper critical field Hc2(0) is ~ 310kOe with a corresponding Ginzburg-Landau coherence length of ~100{\AA} . In the normal state the {\rho} ~ T2 is not indicated. Our magnetization and electrical transport measurements substantiate the appearance of bulk superconductivity in as synthesized Bi4O4S3. On the other hand same temperature heat treated Bi is not superconducting, thus excluding possibility of impurity driven superconductivity in the newly discovered Bi4O4S3 superconductor.Comment: 12 pages Text + Fig

Design of Low Voltage Improved performance Current Mirror

This paper proposes a low voltage current mirror circuit with low input impedance and high output impedance. These improvements are obtained by adding an amplifier which provides biasing voltage to the transistors. Its operation and results are compared with conventional and cascode current mirror circuits. The circuits are designed using Tanner EDA Tool in 90nm CMOS technology with 0.8V supply voltage. Simulation results shows that the minimum output voltage is reduced to 0.1 V, also input resistance is reduced to 0.179k? and consumes only 46µW power. Keywords: Current mirror, Input resistance Output resistance, Input compliance voltage, Output compliance voltage